Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major

Ghahremanlu, E.; Banihashem, Abdollah; Saber, Hamidreza; Tavallaie, Shima; Mirhosseini, Naghmeh; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1159/000339502

Cited by 5 publications

(1 citation statement)

References 115 publications

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“…[ 18 ], included 90 patients with BTM and 90 healthy individuals (control group) and demonstrated increased levels of PAB and ferritin in the patients compared with the controls; however, there was no significant relationship between these two indicators in their study. In addition, several other case-control studies have examined PAB- and BTM-related variables [ 19 - 21 ]. This present cross-sectional study showed a direct association between oxidative stress and serum-ferritin levels.…”

Section: Discussionmentioning

confidence: 99%

The association of pro-oxidant/antioxidant balance and blood parameters in patients with beta-thalassemia major: a cross-sectional study

Parvizi,

Moghaddam,

Nazari

et al. 2023

Blood Res

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Background Oxidative stress due to iron accumulation in patients with beta-thalassemia major (BTM) causes complications such as tissue damage and destruction. This study aimed to assess the association between the serum prooxidant/antioxidant balance (PAB) and blood parameters in patients with BTM. Methods This cross-sectional study included 92 patients with BTM. In this study, PAB was measured using an enzyme-linked immunosorbent assay (ELISA). Serum ferritin, blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid-stimulating hormone (TSH), total cholesterol (TC), triglyceride (TG), complete blood cell count (CBC), and history of blood transfusion were recorded. The association of the blood parameters was assessed across the tertiles (T) of serum PAB (highest T vs. lowest T). Results The results showed that high serum ferritin was directly associated with serum PAB [odds ratio (OR), 12.80; 95% confidence interval (CI), 2.98‒54.91; T3 vs. T1]. Also, direct associations were found for high TC (OR, 4.97; 95% CI, 1.42‒17.32; T3 vs. T1), high ALT (OR, 4.95; 95% CI, 1.33‒18.46; T3 vs. T1) and high TSH (OR, 3.78; 95% CI, 1.10‒13.02; T3 vs. T1). Conclusion The findings of the present study showed that serum PAB levels were directly associated with ferritin, ALT, TC, and TSH levels. This indicates that improvements in blood parameters, especially ferritin and TSH levels, occur by ameliorating oxidative stress in patients with BTM.

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Section: Discussionmentioning

confidence: 99%

The association of pro-oxidant/antioxidant balance and blood parameters in patients with beta-thalassemia major: a cross-sectional study

Parvizi,

Moghaddam,

Nazari

et al. 2023

Blood Res

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Effects of cadmium and 17β-estradiol on Mytilus galloprovincialis redox status. Prooxidant–antioxidant balance (PAB) as a novel approach in biomonitoring of marine environments

Koutsogiannaki

Franzellitti

Kalogiannis

et al. 2015

Marine Environmental Research

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Anemia is associated with cognitive impairment in adolescent girls: A cross-sectional survey

Bahrami

Khorasanchi

Tayefi

et al. 2019

Applied Neuropsychology: Child

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Anemia is associated with impairment in oxygen transport, affecting an individual's physical and mental wellbeing, and work performance. The aim of this study was to examine the prevalence of anemia and its possible association with serum antibody titers to Hsp27 (as an indicator of cellular stress), cognitive function, measures of emotion, sleep patterns in adolescent girls. A total of 940 adolescent girls were assessed to evaluate neuropsychological function with validated questionnaires. A complete blood count was determined as part of the assessment of hematological parameters. Serum anti-Hsp27 was measured for each subject. Among the total of 940 participants, 99 girls (10.5%) were anemic [hemoglobin <12(g/dl)]. Serum anti-HSP27 was significantly higher in anemic compared to healthy girls (p<0.05). There was no significant differences in depression, aggression, insomnia, daytime sleepiness and sleep apnea score between two groups. However, the total cognitive abilities score was significantly lower in the anemic girls (76.8±2.1 versus 85.7±2.5, p = 0.002). Logistic regression analysis showed that anemic girls were 1.73 times more likely than non-anemic girls to have cognitive impairment (95% confidence interval [CI] = 1.07-2.78; P = 0.025). Anemia was associated with elevated levels of anti-HSP27 and supports the hypothesis that cellular stress may be associated with anemia. Anemia was adversely associated with an assessment of cognitive abilities and was an independent risk factor for cognitive impairment in this group.

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Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major

Cited by 5 publications

References 115 publications

The association of pro-oxidant/antioxidant balance and blood parameters in patients with beta-thalassemia major: a cross-sectional study

The association of pro-oxidant/antioxidant balance and blood parameters in patients with beta-thalassemia major: a cross-sectional study

Effects of cadmium and 17β-estradiol on Mytilus galloprovincialis redox status. Prooxidant–antioxidant balance (PAB) as a novel approach in biomonitoring of marine environments

Anemia is associated with cognitive impairment in adolescent girls: A cross-sectional survey

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