Increased Serum IgE in Alcoholics: Relationship With Th1/Th2 Cytokine Production by Stimulated Blood Mononuclear Cells

Domínguez-Santalla, Maria-Jesus; Vidal, Carmen; Viñuela, Juan E.; Pérez, Luis‐Fernando; González‐Quintela, Arturo

doi:10.1111/j.1530-0277.2001.tb02336.x

Cited by 60 publications

(80 citation statements)

References 44 publications

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“…Likewise, it has been shown that ethanol-related IgE increase is independent of associated habits such as smoking, both in alcoholics and in a defined healthy population (González-Quintela et al, 2000). From this data it may be hypothesized that IgE increases in alcoholics might be due to alcohol and its metabolites per se, which would mean that alcohol could act as an additional antigen or allergen (Domínguez-Santalla et al, 2001). …”

Section: Ethanol and Humoral Immunitymentioning

confidence: 99%

Influence of alcohol consumption on immunological status: a review

et al. 2002

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The aim of this review is to present and discuss the effect of different levels of alcohol consumption on the immune system. Not only the amount consumed but also the type of alcoholic beverage have to be taken into account in order to determine the consequences on activity, number, distribution, balance, interaction and response of immunocompetent cells. The association between alcohol exposure and the risk of developing an alcohol-related disease is multifactorial. In fact, age, gender, smoking habits, dietary intake and exercise are involved among other factors. The evaluation of the host cellular and humoral immune responses has shown that alcohol may induce some benefits when consumption is moderate. Moreover, those alcoholic beverages that contain antioxidants, such as red wine, could be protectors against immune cell damage. According to the literature consulted, the daily consumption of 10 -12 g and 20 -24 g of alcohol for women and men, respectively, is considered to be a moderate intake; the type of beverage has been established not to be important when defining moderation. Particular attention is often focused on the U-or J-shaped curve which also suggests that light to moderate drinking produces a protective effect. Such an inverse relationship indicates a reduction of risk for both light and moderate consumers and a higher risk not only for hard drinkers, but also for non-consumers.

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Section: Ethanol and Humoral Immunitymentioning

confidence: 99%

Influence of alcohol consumption on immunological status: a review

et al. 2002

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“…The interaction between alcohol and the immune system is very complex (29,30). Modification of a diversity of immune responses may be involved, such as loss of natural killer cell activity (31), changes in immunoglobulins (32,33,34), and altered cytokine production (32). Moreover, human studies of high alcohol intake individuals as well as animal studies have revealed alterations in both Th1-and Th2-mediated immunity (35).…”

Section: Alcohol and Autoimmunitymentioning

confidence: 99%

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Carlé

Pedersen

Knudsen

et al. 2012

European Journal of Endocrinology

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ObjectiveAlcohol consumption is an important protective risk factor for many autoimmune diseases. We wished to study the association between alcohol consumption and autoimmune hypothyroidism.DesignPopulation-based, case–control study, 1997–2001, Denmark.MethodsPatients with newly diagnosed autoimmune overt hypothyroidism (n=140) were prospectively identified in a population (2 027 208 person-years of observation), and their matched controls with normal thyroid function (n=560) were recruited simultaneously from the same population. Participants gave information on alcohol intake, smoking, previous diseases, education, and family history of hypothyroidism. The association between alcohol intake and development of hypothyroidism was analyzed in conditional regression models.ResultsHypothyroid cases had reported a lower alcohol consumption than controls (median units of alcohol (12 g) per week: 3 vs 5,P=0.002). In a multivariate regression model, alcohol consumption was associated with a reduction in risk for development of overt autoimmune hypothyroidism. Odds ratios (95% confidence interval) compared with the reference group with a recent (last year) consumption of 1–10 units of alcohol per week were as follows: 0 units/week, 1.98 (1.21–3.33); 11–20 units/week, 0.41 (0.20–0.83); and ≥21 units/week, 0.90 (0.41–2.00). Similar results were found for maximum previous alcohol consumption during a calendar year. No interaction was found with type of alcohol consumed (wine vs beer), sex, or region of inhabitancy.ConclusionsAlcohol consumption seems to confer considerable protection against development of overt autoimmune hypothyroidism irrespective of sex and type of alcohol consumed.

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“…Evidence that EtOH polarizes the immune response toward Th2-driven humoral immunity is reported in alcoholics (25). We hypothesize that phenotypical and functional changes induced by in vitro EtOH exposure ofcontrol iDCs, even though quantitatively small, together with other possible ethanol-induced DC changes, may be responsible for the observed Th2 cell polarization.…”

Section: Discussionmentioning

confidence: 93%

Chronic and Acute Alcohol Exposure Prevents Monocyte-Derived Dendritic Cells from Differentiating and Maturing

Buttari

Profumo

Mancinelli

et al. 2008

Int J Immunopathol Pharmacol

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Increasing evidence suggests that alcohol abuse may be linked to adverse immunomodulatory effects on immune responses. Our study was undertaken to clarify the immunological consequences of chronic and acute alcohol exposure on differentiation and maturation of human dendritic cells (DCs). Using immunochemical and cytoftuorimetric analysis we determined the phenotype and functions of monocyte-derived DCs from alcoholics and healthy subjects and analyzed their ability to respond to lipopolysaccharide (LPS) in the presence or absence of ethanol (EtOH) exposure. Our results showed that alcoholics' monocytes differentiated to immature DCs with altered phenotype and functions (aleiDCs). Alc-iDCs showed fewer Clrla" cells, weaker CD86 expression and higher HLA-DR expression associated with lower endocytosis and allostimulatory functions than iDCs from healthy subjects (control-iDCs). Despite these impairments, alc-iDCs produced TNF-a and IL-6 in large amounts. LPS stimulation failed to induce full phenotypical and functional alc-iDC maturation. In vitro acute EtOH exposure also prevented alc-iDCs and control-iDCs from maturing in response to LPS. T-cell priming experiments showed that EtOH treatment prevented LPS-stimulated control-iDCs from priming and polarizing naive allogeneic T cells into Thl cells, thus favouring a predominant Th2 environment. Collectively, our results provide evidence that chronic and acute alcohol exposure prevents DCs from differentiating and maturing in response to a microbial stimulus.Emerging evidence shows an increased incidence of infectious diseases, as well as a greater susceptibility to cancer in humans chronically abusing alcohol (1-5). Evidence from human and animal studies in vivo, as well as from in vitro experiments suggests that alcohol abuse may exert adverse immunomodulatory effects on innate and adaptive immune responses (4, 6-9). Alcoholinduced immune dysfunctions depend on various factors including the dose and duration of alcohol exposure (chronic vs acute) and on the presence and characteristics of additional stimuli such as microbial molecules.In chronic alcoholics and in a chronic ethanolfeeding model in mice, impaired antigen-specific T cell proliferation and a delayed-type hypersensitivity

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Increased Serum IgE in Alcoholics: Relationship With Th1/Th2 Cytokine Production by Stimulated Blood Mononuclear Cells

Abstract: Increased total serum IgE is observed in alcoholics together with a paradoxically low ratio of Th2 to Th1 cytokine production by phytohemagglutinin-stimulated PBMCs. These findings are independent of the atopic status of patients.

Cited by 60 publications

References 44 publications

Influence of alcohol consumption on immunological status: a review

Influence of alcohol consumption on immunological status: a review

Moderate alcohol consumption may protect against overt autoimmune hypothyroidism: a population-based case–control study

Chronic and Acute Alcohol Exposure Prevents Monocyte-Derived Dendritic Cells from Differentiating and Maturing

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