Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer

Suzuki, Yuzo; Suda, Takafumi; Furuhashi, Kazuki; Suzuki, Masako; Fujie, Manabu; Hahimoto, Dai; Nakamura, Yutaro; Inui, Naoki; Nakamura, Hirotoshi; Chida, Kingo

doi:10.1016/j.lungcan.2009.05.001

Cited by 224 publications

(239 citation statements)

References 22 publications

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“…The authors measured serum kynurenine and tryptophan concentrations and estimated IDO activity by calculating the kynurenine to tryptophan ratio (Suzuki et al, 2010). However, the assessment was indirect and based on kynurenine and tryptophan concentrations which are relatively unstable substances.…”

Section: Discussionmentioning

confidence: 99%

“…Overall invasiveness of malignant tumors is dependent on the properties of the tumor at the molecular level (Watanabe et al, 2011), as well as on the proper response of the immune system (Dai et al, 2010 tumors, including lung cancer, may be attributed to metabolites of tryptophan degradation via kynurenine pathway (Munn and Mellor, 2007;Suzuki et al, 2010). It is the main pathway for tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase (IDO) and kynurenine aminotransferases (KATs), resulting in synthesis of kynurenic acid (KYNA) (Figure 1) (Fulop et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Serum Kynurenic Acid: Possible Association with Invasiveness of Non-small Cell Lung Cancer

Sagan

Kocki²,

Kocki³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The lung adenocarcinoma is considered more aggressive than other types of non-small cell lung cancer. As metabolites of tryptophan degradation along the kynurenine pathway, including kynurenic acid, have been shown to induce immunosuppression and facilitate escape of tumor cells from immune surveillance, a hypothesis was set up that differences in biological behavior between types of lung cancer may be associated with altered activity of the kynurenine metabolic pathway. The aim of the study was to determine kynurenic acid levels in the serum of patients with bronchial adenocarcinoma for comparison with other types of non-small cell lung cancer. A total of 227 patients with non-small cell lung cancer were enrolled in the study, including 71 with adenocarcinoma and 96 with squamous cell carcinoma. Serum kynurenic acid concentration was determined with use of high performance liquid chromatography and fluorometry. The level of kynurenic acid in the serum of patients with adenocarcinoma was significantly higher than in those with squamous cell lung cancer (107.1 ± 62.8 pmol/ml; 95%CI: 92.4 to 132.3 pmol/ml versus 82.1 ± 47.6 pmol/ml; 95%CI: 78.5 to 91.2 pmol/ml, respectively; p = 0.027). Differences between other histological types of lung cancer were insignificant. We conclude that increased activity of kynurenine metabolic pathway manifested by elevated serum kynurenic acid level may be one of the factors associated with clinically distinct biological behavior of adenocarcinoma, in particular high invasiveness and rapid progression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Kynurenic Acid: Possible Association with Invasiveness of Non-small Cell Lung Cancer

Sagan

Kocki²,

Kocki³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…A significant correlation was observed between neopterin concentration and kynurenine/ tryptophan ratio (88). In patients with lung cancer, the kynurenine/tryptophan ratio was reported to correlate with advanced stage (121). In colorectal cancer patients, serum tryptophan correlated inversely with parameters of quality of life (122).…”

Section: Neopterin and Toxicity Of Anticancer Therapymentioning

confidence: 92%

Neopterin as a biomarker of immune response in cancer patients

Melichar¹,

Spisarová²,

Bartoušková³

et al. 2017

Ann. Transl. Med.

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“…It is methodologically complex to measure cellular IDO and TDO activity directly in an epidemiologic setting, but the ratio between circulating kynurenine and tryptophan (KTR) is widely accepted as an indirect measure of IDO activity (11,13). Circulating tryptophan and kynurenine concentrations have been associated with poor outcome among patients with lung cancer (17,18), but have not yet been evaluated in relation to lung cancer incidence in a prospective setting.…”

Section: Introductionmentioning

confidence: 99%

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Chuang

Fanidi

Ueland

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated in several cancers, including lung cancer.Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) that included 893 incident lung cancer cases and 1,748 matched controls. Circulating levels of tryptophan and six of its metabolites were measured and evaluated in relation to lung cancer risk.Results: Tryptophan (P trend ¼ 2 Â 10

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Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer

Cited by 224 publications

References 22 publications

Serum Kynurenic Acid: Possible Association with Invasiveness of Non-small Cell Lung Cancer

Serum Kynurenic Acid: Possible Association with Invasiveness of Non-small Cell Lung Cancer

Neopterin as a biomarker of immune response in cancer patients

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

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