Increased serum laminin and angiogenin concentrations in patients with peripheral arterial occlusive disease.

Abstract

Aim-To measure serum laminin and angiogenin concentrations in patients with peripheral arterial occlusive disease (PAOD) Fontaine stages IIb, III, and IV.Methods-The study population comprised 38 patients (20 men and 18 women) with stage IV PAOD, 11 patients (six men and five women) with stage III PAOD, 18 patients (10 men and eight women) with stage Ilb PAOD, and 23 patients (10 men and 13 women) with deep vein thrombosis. Fifteen normal subjects (matched for risk factors) and 10 patients (five men and five women) without PAOD served as controls. Serum samples were obtained at admission and serum laminin and angiogenin concentrations were measured using an enzyme linked immunosorbent assay. Results-Patients with stage IV PAOD had higher serum laminin (mean ± SEM; 826 ± 97 ng/ml) and angiogenin concentrations (467 ± 26 pglml) than normal subjects (laminin: 379 ± 21 ng/ml; angiogenin: 358 ± 16 pgiml) and patients without PAOD (laminin: 277 ± 34 ng/ml; angiogenin: 406 ± 25 pglml). A significant correlation was found between angiogenin and laminin and between serum laminin and fibrinogen concentrations in patients with stage IV disease. Conclusions-Raised laminin and angiogenin concentrations may be indicators of endothelial damage caused by reduced vascular perfusion or compensatory revascularisation, or both. (7 Clin Pathol 1996;49:508-5 10)

Angiogenin expression in the sera and skin of patients with rheumatic diseases

“…First, there was no significant difference in the serum angiogenin levels among normal subjects and patients arterial occlusive disease as well as inflammatory arthritis (21)(22)(23)(24). Our research is the first to measure serum angiogenin levels in patients with PM/DM, SSc and SLE, but we didnot find any significant difference between controls and these patients.…”

“…Various cell types including vascular endothelial cells, smooth muscle cells, fibroblasts, and lymphocytes are thought to express angiogenin (4,5). In addition, circulating angiogenin has been detected in normal serum (6,7).…”

Three decades of research on angiogenin: a review and perspective

“…ANG also plays a role in a variety of nonmalignant pathological conditions, such as endometriosis [149], peripheral vascular disease [150], inflammatory bowel disease (IBD) [12], rheumatoid arthritis [151], and diabetes [152,153]. However, the majority of the related studies focused on the serum level of ANG in nonmalignant diseases.…”

Homocysteine and Laminin Are Not Prognostic Markers in Patients with Septic Inflammatory Response Syndrome

“…It has been argued that increased values of laminin might be an indicator of endothelial cell damage (4).…”