Increased Serum Levels of Growth-Related Oncogene-α in Patients with Generalized Pustular Psoriasis

Kato, Yoshihiro; Yamamoto, Toshiyuki

doi:10.1159/000258674

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…For all five patients, GMA was performed by using the Adacolumn (JIMRO, Takasaki, Japan) designed Adsorptive Depletion of CD16 + Monocytes 437 to selectively deplete granulocytes and monocytes, according to previously described methods (5,(7)(8)(9)(10)(11). Briefly, the column is an adsorptive type leukocytapheresis medical device filled with cellulose acetate beads of 2 mm in diameter as the column adsorptive carriers (11,16).…”

Section: Adsorptive Granulocyte and Monocyte Apheresismentioning

confidence: 99%

“…Granulocyte and monocyte adsorption apheresis (GMA) has been used for over a decade in Japan and European countries as an extracorporeal therapeutic intervention in patients with rheumatoid arthritis (RA) and inflammatory bowel diseases (IBD) (5) such as ulcerative colitis (UC) and Crohn's disease (CD) which are refractory to conventional drugs including biologics (6). Further, in recent years, several reports have shown striking efficacy for GMA in patients with various skin disorders (1,7–10). GMA uses a column filled with cellulose acetate beads, which adsorbs approximately 65% of granulocytes, 55% of monocytes from blood in the column (6,11).…”

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confidence: 99%

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Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

et al. 2012

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Generalized pustular psoriasis (GPP) is a subtype of psoriasis with strong association with activated neutrophils. Adsorptive granulocyte and monocyte apheresis (GMA) is an extracorporeal intervention for selective depletion of activated granulocytes and monocytes. However, the immunological mechanism(s) for the effect of GMA on patients is not fully defined yet. We investigated the effects of GMA on the ratio of CD14(+) CD16(+) proinflammatory monocytes/CD14(+) monocytes and cytokine/chemokine production by these leukocytes including CXCL8, CCL2, CCL3, CCL4, CCL5 and tumor necrosis factor (TNF)-α in five patients with active GPP. CD14(+) CD16(+) monocytes were significantly elevated in patients with active GPP, and GMA markedly reduced the CD14(+) CD16(+) /CD14(+) ratio together with improvement of patients' clinical symptoms. The serum levels of CXCL8, CCL3 and CCL4 were increased in active GPP patients. Likewise, CCL2 production from monocytes was increased in active GPP patients. Further, CCL3 and CCL4 production from monocytes in active GPP patients were reduced after a course of GMA. Serum CCL5 level and the release of CCL5 from monocytes in active GPP were significantly reduced, but TNF-α level in active GPP was similar to controls. Based on these results, we believe that in addition to neutrophils, elevated CD14(+) CD16(+) proinflammatory monocytes are part of the immune pathology in GPP. Accordingly, selective depletion of CD14(+) CD16(+) monocytes by GMA should be therapeutic in this condition.

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Section: Adsorptive Granulocyte and Monocyte Apheresismentioning

confidence: 99%

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confidence: 99%

Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

et al. 2012

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Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA

Shibata

Sugiura

Furuta³

et al. 2017

Journal of Autoimmunity

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The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin

Korbecki

Maruszewska

Bosiacki

et al. 2022

IJMS

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In this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils. The aim of this study was to describe the significance of CXCL1 in selected diseases of the cardiovascular system (atherosclerosis, atrial fibrillation, chronic ischemic heart disease, hypertension, sepsis including sepsis-associated encephalopathy and sepsis-associated acute kidney injury), the respiratory system (asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis, coronavirus disease 2019 (COVID-19), influenza, lung transplantation and ischemic-reperfusion injury and tuberculosis) and the skin (wound healing, psoriasis, sunburn and xeroderma pigmentosum). Additionally, the significance of CXCL1 is described in vascular physiology, such as the effects of CXCL1 on angiogenesis and arteriogenesis.

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Increased Serum Levels of Growth-Related Oncogene-α in Patients with Generalized Pustular Psoriasis

Cited by 3 publications

References 9 publications

Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA

The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin

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Increased Serum Levels of Growth-Related Oncogene-α in Patients with Generalized Pustular Psoriasis

Cited by 3 publications

References 9 publications

Adsorptive Depletion of CD14+CD16+ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

Adsorptive Depletion of CD14+CD16+ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA

The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin

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Product

Resources

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Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines

Adsorptive Depletion of CD14⁺CD16⁺ Proinflammatory Monocyte Phenotype in Patients With Generalized Pustular Psoriasis: Clinical Efficacy and Effects on Cytokines