Increased serum lipofuscin associated with leukocyte telomere shortening in veterans: a possible role for sulfur mustard exposure in delayed-onset accelerated cellular senescence

Nasiri, Leila; Vaez-Mahdavi, Mohammad-Reza; Hassanpour, Hossein; Ghazanfari, Tooba; Ardestani, Sussan Kaboudanian; Askari, Nayere; Majd, Mohammad-Ali Mohseni; Rahimlou, Bahman

doi:10.1016/j.intimp.2022.109549

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Biological aging, in turn, promotes subsequent aging. Thus, telomere attrition may progress aging via cellular senescence [17,18]. Immune cells differ from normal somatic cells in that they can regulate telomerase, the telomere-extending enzyme, and limit telomere attrition in activated cells undergoing cell division.…”

Section: Introductionmentioning

confidence: 99%

The Ratio of Biological Health Score to Immune Cell Telomere Length: A Reliable Index Indicating the Association Between the Severity of Injury and Senescence in Mustard-chemical Veterans

Vaez-Mahdavi,

Ghazanfari,

Nasiri

et al. 2023

Immunoregulation

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Background: Sulfur mustard (SM), a chemical weapon used in the Iraq-Iran war from 1983-1988, has multiple chronic complications. This study aimed to evaluate one of the long-act effects of SM, i.e. the senescence according to the severity of injury in veterans via the estimation of biological health score (BHS) and relative telomere length (TL) of immune cells. Materials and Methods: SM-chemical veterans were categorized into three groups according to the percentage of chemical injury (5-20%, 25-45%, and 50-70%). Healthy volunteers also participated as a control group. Eighteen biomarkers from different physiological systems (inﬂammatory/immune, endocrine, cardiovascular, and metabolic), and organs (liver and kidney) were used to estimate BHS. The TL of immune cells was also measured for each participant by monochrome multiplex real-time PCR. Results: There were significant correlations between age-adjusted TL (negative), BHS, and BHS/TL ratio (positive) and the percentage of injury. The TL was significantly decreased in all veterans with different injuries compared to healthy participants while it did not change in veterans with the injury percentages of 25-45% and 50-70%. The BHS in three groups of veterans was significantly higher than in healthy individuals. The BHS/TL ratio was significantly changed between all groups and increased with the progress of injury. Conclusion: The BHS and TL may not individually be accurate indices for the determination of senescence and biological aging while the ratio of these two parameters improves this defect and could be a more reliable index indicating biological aging in chemical veterans with different percentages of injury.

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Section: Introductionmentioning

confidence: 99%

The Ratio of Biological Health Score to Immune Cell Telomere Length: A Reliable Index Indicating the Association Between the Severity of Injury and Senescence in Mustard-chemical Veterans

Vaez-Mahdavi,

Ghazanfari,

Nasiri

et al. 2023

Immunoregulation

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Relationships between DNA oxidative damage, testosterone, and body mass index in sulfur mustard-chemical veterans

Nasiri,

Vaez-Mahdavi,

Hassanpour

et al. 2024

Toxicologie Analytique et Clinique

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Transcription of biological aging markers (ANRIL, P16ink4a, TBX2, and TERRA) and their correlations with severity of sulfur mustard exposure in veterans

Nasiri

Vaez-Mahdavi

Hassanpour

et al. 2023

Preprint

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Sulfur mustard (SM) exposure has delayed harmful effects, including cell senescence and premature biological aging. This study aimed to evaluate the expression of four main markers of biological aging (i.e., ANRIL, P16ink4a, TBX2, and TERRA) and assess their correlation with the severity of SM exposure in the long term. The study was conducted on two groups of volunteers. 1) the SM-exposed group, exposed to SM once in 1987 during the Iraq-Iran war. This group was divided into three subgroups based on the injury severity, asymptom (exposure to SM without any clinical signs), mild, and severe subgroups; 2) the non-exposed group. ANRIL and TBX2 transcripts were reduced in the total SM-exposed people. Their reduction was more considerable in the SM-exposed subgroups of mild and severe. On the other hand, P16ink4a and TERRA transcripts were increased due to SM exposure. The increase of TERRA expression was more significant in the asymptom, mild and severe subgroups, while P16ink4a was only higher in the asymptom subgroup. There was a positive correlation between the TERRA transcript and the severity of injury, while this correlation was negative for the ANRIL transcript. Thus, the delayed toxicity of SM is associated with the dysregulation of aging markers leading to progressive premature cellular senescence that is dependent on the severity of SM exposure.

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Increased serum lipofuscin associated with leukocyte telomere shortening in veterans: a possible role for sulfur mustard exposure in delayed-onset accelerated cellular senescence

Cited by 4 publications

References 40 publications

The Ratio of Biological Health Score to Immune Cell Telomere Length: A Reliable Index Indicating the Association Between the Severity of Injury and Senescence in Mustard-chemical Veterans

The Ratio of Biological Health Score to Immune Cell Telomere Length: A Reliable Index Indicating the Association Between the Severity of Injury and Senescence in Mustard-chemical Veterans

Relationships between DNA oxidative damage, testosterone, and body mass index in sulfur mustard-chemical veterans

Transcription of biological aging markers (ANRIL, P16ink4a, TBX2, and TERRA) and their correlations with severity of sulfur mustard exposure in veterans

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