Increased serum neopterin levels in adults with Down syndrome

Mehta, Pankaj; Patrick, Bruce A.; Dalton, Arthur J.; Patel, Bindu; Mehta, Sangita P.; Pirttilä, Tuula; Coyle, Patricia K.

doi:10.1016/j.jneuroim.2005.03.010

Cited by 11 publications

(12 citation statements)

References 38 publications

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“…Since the latter participate in the effector functions of monocytes and macrophages, the data support the use of neopterin as an immune activation marker. The higher neopterin levels seen in the DS group than in controls are consistent with the increased levels reported in adults or older persons with DS and patients with AD [15,40,41]. The data indicate a chronic state of cellular immune activation in DS.…”

Section: Discussionsupporting

confidence: 86%

“…In addition to being a marker of interferon activity, neopterin induces or enhances cytotoxicity and exhibits antioxidant properties [13]. Recent studies showed higher levels of plasma neopterin in older persons with DS than controls; [15] however, none examined the levels in children or adolescents with DS. Because reports [12,16] indicate that inflammatory and immune mechanisms are involved in the pathogenesis of DS, and increased Aβ42 levels are found in their brain extracts, we hypothesized that neopterin levels would be higher in children with DS than in controls and would correlate with plasma Aβ40 and Aβ42 levels.…”

Section: Introductionmentioning

confidence: 99%

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Increased amyloid β protein levels in children and adolescents with Down syndrome

Mehta

Capone

Jewell

et al. 2007

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Increased amyloid β protein levels in children and adolescents with Down syndrome

Mehta

Capone

Jewell

et al. 2007

Journal of the Neurological Sciences

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“…Therefore, plasma Aβ is less likely to be the cause for the increase in neopterin level in this study. This is also consistent with another study that showed no correlation between serum neopterin and Aβ levels in patients with Down syndrome (Mehta et al , ). However, we cannot rule out the possibility that other inflammatory mediators exiting from the brain (Banks et al , ) may be contributing to the peripheral cellular immune activation and hence higher neopterin levels.…”

Section: Discussionsupporting

confidence: 93%

Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease

Parker

Mielke

et al. 2012

Int J Geriat Psychiatry

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Objective Alterations of the immune system play important roles in Alzheimer’s disease (AD). The primary purpose of this study was to compare plasma levels of neopterin, a marker of cellular immune activity, in amnestic Mild Cognitive Impairment (aMCI), early (mild to moderate) AD, and cognitively normal controls (NC). In addition, correlation of plasma neopterin with interferon-gamma (INF-γ) and Interleukin-6 (IL-6) were also examined. Methods Plasma samples from patients with mild to moderate AD (N=35), aMCI (N= 24), and cognitively normal controls (N = 29) were obtained from the Johns Hopkins Alzheimer’s Disease Research Center. Plasma neopterin, INF-γ, and IL-6 levels were measured using commercially available ELISAs. Multiple linear regression was performed to study differences in the baseline neopterin levels between normal, aMCI and AD patients. Pearson correlation coefficients were estimated for neopterin and INF-γ and IL-6 levels. All analyses were conducted using SAS and GraphPad softwares. Results AD subjects had significantly higher neopterin values compared to aMCI (β = 0.202, p= 0.004) and normal (β = 0.263, p=0.0004) subjects. There was no statistically significant difference between normal and aMCI. A significant association between INF-γ (r = 0.41, p<0.0001) and IL-6 (r = 0.35, p=0.0006) levels were found. Conclusions Our study demonstrates that peripheral immune response may be stronger in later stages of AD pathophysiology, when dementia has developed.

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“…3 Plata-Nazar K. et al: Clinical Usefulness of Neopterin Concentration reflects the chronic stimulation of the immune system in these conditions and contributes to better understanding of their pathogenesis. It must be also noted, that high concentrations of the neopterin have been also reported in adults with Down's syndrome (121).…”

Section: Diseases Of Eldery Neurodegenerationmentioning

confidence: 93%

Clinical Usefulness of Determining the Concentration of Neopterin

Plata-Nazar

Jankowska

2011

Pteridines

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Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased serum concentration of neopterin is observed in conditions with cell-mediated immune response involvement. In clinical practice, neopterin evaluation is applied in medical conditions such as: infectious diseases, oncology, rheumatology, transplantology, transfusiology, cardiology, neurology and many others. Neopterin can be detected in serum, urine, cerebrospinal fluid, synovial fluid, saliva, ascitic fluid, bile, pancreatic juice and gastric juice. In recently published studies, various non-specific indicators of inflammation such as neopterin, C-reactive protein, procalcitonin were compared and proved to be independently useful.

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Increased serum neopterin levels in adults with Down syndrome

Cited by 11 publications

References 38 publications

Increased amyloid β protein levels in children and adolescents with Down syndrome

Increased amyloid β protein levels in children and adolescents with Down syndrome

Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease

Clinical Usefulness of Determining the Concentration of Neopterin

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