Increased Serum Neurotrophin Levels Related to Alcohol Use Disorder in a Young Population Sample

Lhullier, Alfredo Cardoso; Moreira, Fernanda Pedrotti; Silva, Ricardo A. da; Marques, Melina Bazili; Bittencourt, Guilherme; Pinheiro, Ricardo Tavares; Souza, Luciano D.M.; Portela, Luis Valmor; Lara, Diogo R.; Jansen, Karen; Wiener, Carolina David; Oses, Jean Pierre

doi:10.1111/acer.12592

Cited by 22 publications

(15 citation statements)

References 36 publications

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Section: Discussionmentioning

confidence: 53%

“…We found that 9.6% of individuals in our sample had alcohol abuse and/or dependence, which is consistent with previous studies. 6,17 Moreover, in our study, alcohol abuse and/or dependence were associated with male gender, tobacco use, and illicit drug use, and was often comorbid with anxiety disorders, mood disorder, and risk of suicide.Several studies have discussed the relationship between AUD and gender, in which males are more likely than females to engage in binge drinking, and therefore, to have AUDs. 18,19 A study performed in 2013 involving 6,478 subjects found that alcohol abuse and/or dependence were more prevalent among males (22.0%) than females (9.8%).…”

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confidence: 53%

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Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study

Wiener

Moreira

Zago

et al. 2017

Rev. Bras. Psiquiatr.

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Objective: To evaluate the prevalence of alcohol abuse and/or dependence in a population-based sample of young adults and assess the prevalence of comorbid mood disorders, anxiety, and suicide risk in this population. Methods: This cross-sectional, population-based study enrolled 1,953 young adults aged 18-35 years. The CAGE questionnaire was used to screen for alcohol abuse and/or dependence, with CAGE scores X 2 considered positive. Psychiatric disorders were investigated through the structured Mini International Neuropsychiatric Interview (MINI). Results: Alcohol abuse and/or dependence was identified in 187 (9.60%) individuals (5.10% among women and 15.20% among men). Alcohol abuse and/or dependence were more prevalent among men than women, as well as among those who used tobacco, illicit drugs or presented with anxiety disorder, mood disorder, and suicide risk. Conclusion: These findings suggest that alcohol abuse and/or dependence are consistently associated with a higher prevalence of psychiatric comorbidities, could be considered important predictors of other psychiatric disorders, and deserve greater public heath attention, pointing to the need for alcohol abuse prevention programs.Keywords: Alcohol abuse and/or dependence; anxiety; mood disorder; depression; suicide risk IntroductionAlcohol consumption is highly prevalent worldwide and has numerous negative consequences for health and quality of life, especially in the young population. 1 Alcohol use disorders (AUDs) are among the most frequently diagnosed disorders, with a 12-month prevalence rate of 8.5%. 2 In the United States alone, according to the 2013 National Survey on Drug Use and Health, 37.9% of young adults reported binge drinking (four or more drinks for women and five or more drinks for men on an occasion) at least once in the past 30 days. 3 Moreover, studies have shown a higher prevalence of cigarette smoking or drug abuse among subjects who engage in heavy or frequent binge drinking. [3][4][5] AUDs are highly comorbid with mood and anxiety disorders in adults and are associated with substantial societal and personal costs. In a study conducted by Grant et al., among adults seeking treatment for an AUD, 40.69% and 33.3% were diagnosed with at least one current comorbid mood disorder and anxiety disorder, respectively. 6 The diagnosis of current mood or anxiety disorders among individuals with AUD is challenging, because many symptoms of intoxication, for example, resemble those of mood and anxiety disorders. 7 In addition to mood disorders and anxiety, other serious problems that can develop in people with AUDs include violent behavior and suicide attempts. 8 Alcoholics are 60 to 120 times more likely to attempt suicide compared to the general population. 9 Furthermore, studies demonstrate that 85 out of every 100 individuals who complete suicide had comorbid depression and/or alcoholism. 10 Individuals with AUDs should be evaluated for the risk of suicide whenever they present with depressive symptoms, 11 Psiquiatria. 2018;40:1-5 Br...

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Section: Discussionmentioning

confidence: 53%

mentioning

confidence: 53%

Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study

Wiener

Moreira

Zago

et al. 2017

Rev. Bras. Psiquiatr.

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“…2). Notably, studies in humans reported elevated serum GDNF levels in individuals displaying mild to severe AUD (Lhullier et al 2015), but reduced levels in alcohol-dependent individuals experiencing withdrawal (Heberlein et al 2010), supporting the notion that the GDNF system is sensitive to voluntary alcohol intake and that dysregulation of GDNF expression can be detected across species.…”

Section: Gdnf Is An Alcohol-responsive Genementioning

confidence: 71%

GDNF and alcohol use disorder

et al. 2018

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Glial cell line-derived neurotrophic factor (GDNF) has been extensively studied for its role in the development and maintenance of the midbrain dopaminergic system, although evidence suggests that GDNF also plays a role in drug and alcohol addiction. This review focuses on the unique actions of GDNF in the mechanisms that prevent the transition from recreational alcohol use to abuse. Specifically, we describe studies in rodents suggesting that alcohol acutely increases GDNF expression in the ventral tegmental area, which enables the activation of the mitogen-activated protein kinase signaling pathway and the gating of alcohol intake. We further provide evidence to suggest that GDNF acts in the ventral tegmental area via both nongenomic and genomic mechanisms to suppress alcohol consumption. In addition, we describe findings indicating that when this endogenous protective pathway becomes dysregulated, alcohol intake levels escalate. Finally, we describe the potential use of GDNF inducers as a novel therapeutic approach to treat alcohol use disorder.

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“…The family of neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) are important regulators of neural survival, development, function, and plasticity 6,7. BDNF is a critical neurotrophic factor involved in cell growth, survival, and differentiation by regulating synaptic plasticity and neurogenesis 8.…”

Section: Introductionmentioning

confidence: 99%

Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal

Xia²,

Li³

et al. 2017

NeuroReport

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Neurotrophins, brain-derived neurotrophic factors (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), have been implicated in the modulation of heroin dependency. This study was designed to explore the expression alterations of BDNF, NT-3, and NT-4 in the context of heroin dependence and withdrawal in the rat nucleus accumbens (NAc). Heroin dependence was induced by a progressive intraperitoneal treatment of heroin. The results showed that the expression levels of BDNF and NT-4 were significantly decreased in the NAc of rats with heroin addiction in comparison with the control group, whereas there was a significant increase in BDNF and NT-4 expressions in the groups of rats with both naloxone-induced and spontaneous withdrawal. Moreover, NT-3 expression was markedly increased in the NAc of rats with heroin addiction and spontaneous withdrawal in comparison with the control group, but decreased in the NAc of rats with naloxone-induced withdrawal. These results indicated that chronic administration of heroin results in the alterations of BDNF, NT-3, and NT-4 expressions in the rat NAc. BDNF, NT-3, and NT-4 may play a critical role in the development of heroin dependency and withdrawal.

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Increased Serum Neurotrophin Levels Related to Alcohol Use Disorder in a Young Population Sample

Abstract: These results suggest that elevated neurotrophins are candidate markers for the early stages of alcohol misuse.

Cited by 22 publications

References 36 publications

Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study

Mood disorder, anxiety, and suicide risk among subjects with alcohol abuse and/or dependence: a population-based study

GDNF and alcohol use disorder

Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal

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