Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

Namiduru, Emine Siber; Tarakçıoğlu, Mehmet; Namıduru, Mustafa; Kocabaş, Ramazan; Erbağcı, Binnur; Meram, İclal; Karaoğlan, İlkay; Yılmaz, Necat; Çekmen, Mustafa

doi:10.1016/s2221-1691(11)60104-4

Cited by 14 publications

(9 citation statements)

References 19 publications

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“…The presence of NO was also evaluated in intestinal amebiasis; in these reports, a significant increase in the NO levels in patients with diarrhea was found compared with the control group. These results support that this oxidative molecule possesses a central role in the pathophysiological mechanisms underlying amebiasis (Pérez-Fuentes et al, 2000 ; Namiduru et al, 2011 ).…”

Section: Oxidative and Anti-oxidative Microenvironment In Amebiasissupporting

confidence: 76%

Flavonoids as a Natural Treatment Against Entamoeba histolytica

Martínez-Castillo

Pacheco‐Yépez

Flores-Huerta

et al. 2018

Front. Cell. Infect. Microbiol.

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Over the past 20 years, gastrointestinal infections in developing countries have been a serious health problem and are the second leading cause of morbidity among all age groups. Among pathogenic protozoans that cause diarrheal disease, the parasite Entamoeba histolytica produces amebic colitis as well as the most frequent extra-intestinal lesion, an amebic liver abscess (ALA). Usually, intestinal amebiasis and ALA are treated with synthetic chemical compounds (iodoquinol, paromomycin, diloxanide furoate, and nitroimidazoles). Metronidazole is the most common treatment for amebiasis. Although the efficacy of nitroimidazoles in killing amebas is known, the potential resistance of E. histolytica to this treatment is a concern. In addition, controversial studies have reported that metronidazole could induce mutagenic effects and cerebral toxicity. Therefore, natural and safe alternative drugs against this parasite are needed. Flavonoids are natural polyphenolic compounds. Flavonoids depend on malonyl-CoA and phenylalanine to be synthesized. Several flavonoids have anti-oxidant and anti-microbial properties. Since the 1990s, several works have focused on the identification and purification of different flavonoids with amebicidal effects, such as, -(-)epicatechin, kaempferol, and quercetin. In this review, we investigated the effects of flavonoids that have potential amebicidal activity and that can be used as complementary and/or specific therapeutic strategies against E. histolytica trophozoites. Interestingly, it was found that these natural compounds can induce morphological changes in the amebas, such as chromatin condensation and cytoskeletal protein re-organization, as well as the upregulation and downregulation of fructose-1,6-bisphosphate aldolase, glyceraldehyde-phosphate dehydrogenase, and pyruvate:ferredoxin oxidoreductase (enzymes of the glycolytic pathway). Although the specific molecular targets, bioavailability, route of administration, and doses of some of these natural compounds need to be determined, flavonoids represent a very promising and innocuous strategy that should be considered for use against E. histolytica in the era of microbial drug resistance.

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Section: Oxidative and Anti-oxidative Microenvironment In Amebiasissupporting

confidence: 76%

Flavonoids as a Natural Treatment Against Entamoeba histolytica

Martínez-Castillo

Pacheco‐Yépez

Flores-Huerta

et al. 2018

Front. Cell. Infect. Microbiol.

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“…It has been described that oxidative stress and the presence of free-radical activities in hosts colonized by parasites correlate with the production of specific metabolites, such as advanced oxidative protein product (AOPP) and malondialdehyde (MDA) ( 44 – 46 ). Previous studies have evaluated MDA levels among healthy individuals and people infected by Ascaris lumbricoides ( 45 ), Entamoeba histolytica , and Plasmodium vivax ( 44 ), and all revealed increased levels of MDA in the infected individuals, suggesting that oxidative stress acts as a mediator of tissue damage concurrent with different parasites.…”

Section: Resultsmentioning

confidence: 99%

Asymptomatic Intestinal Colonization with ProtistBlastocystisIs Strongly Associated with Distinct Microbiome Ecological Patterns

et al. 2018

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“…Other studies have shown that high levels of NO are also found in conditions such as HIE, thalassemia, sickle cell disease and amoebiasis enteritis. [20][21][22][23] A cohort study was conducted by Correia-Costa L et al on 313 obese children. They found that the level of biological markers for oxidative stress and NO increased in relation to fat accumulation, as well as an association between increased oxidative stress and increased levels of NO.…”

Section: Discussionmentioning

confidence: 99%

The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure

Parahita

Hardaningsih

Soetadji

2020

Diponegoro. Int. Med. J.

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Introduction: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. The aim of this study is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sectional study was conducted to 50 children aged between 8 – 10 years in agriculture areas of Brebes. Serum MDA and NO level was measured at the same time using ELISA method, data were shown on numerical scale. Statistical analysisby Pearson correlation.Result: Fifty children met the criteria, consisting of 30 males (60%) and 20 females (40%). The mean of serum MDA level in males, females, and total subjects were normal 6.03 (3.86) µg/ mL, 5.18 (2.11) µg/ mL, and 5.69 (2.60) µg/ mL, respectively. The mean of serum NO level in males, females, and total subjects were increased 79.42 (50.78) µmol/ L, 68.11 (50.81) µmol/ L, and 74.90 (50.58) µmol/ L, respectively. There was no association between serum MDA and NO level found.Conclusion: Serum NO level of children living in an area of chronic pesticide exposure was higher than normal value. However, there was no association between serum MDA and NO level found.Key words: pesticides, oxidative stress, malondialdehyde, nitric oxide

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Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis

Abstract: These results suggest that oxidative and nitrosative stress may play a major role in tissue damage in acute intestinal amebiasis patients. Also these parameters can be used to supplement the conventional microscopic method for reliable diagnosis of intestinal amebiasis.

Cited by 14 publications

References 19 publications

Flavonoids as a Natural Treatment Against Entamoeba histolytica

Flavonoids as a Natural Treatment Against Entamoeba histolytica

Asymptomatic Intestinal Colonization with ProtistBlastocystisIs Strongly Associated with Distinct Microbiome Ecological Patterns

The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure

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