Increased Serum Procalcitonin in Newborn Infants without Infection

Sachse, C.; Dressler, Frank; Henkel, E.

doi:10.1093/clinchem/44.6.1343

Cited by 57 publications

(37 citation statements)

References 4 publications

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“…[29][30][31] This may have been partly caused by the discrepancies of blood withdrawal time. Also, other factors than time, such as the ratio of Gram-positive to Gram-negative infections or patients age 15…”

Section: Discussionmentioning

confidence: 99%

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Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates

Fendler

Piotrowski

2007

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 99%

“…13,14 Additionally we planned to compare the PCT concentrations in patients infected with Gram-positive and Gram-negative bacteria. As newborns without infection may also exhibit elevated PCT levels, which revert to normal range in 3-4 days after birth, 15,16 we excluded patients younger than 72 h from our study.…”

mentioning

confidence: 99%

Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates

Fendler

Piotrowski

2007

J Paediatrics Child Health

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“…Luminescence was measured automatically in a Berilux Analyser 250 (Behring Diagnostics, Marburg, Germany). A PCT level of $ 2´0 ng mL 21 was considered to be abnormally elevated [16].…”

Section: Pct Measurementmentioning

confidence: 99%

“…The plasma concentration of PCT increases considerably in both children [11,12] and adults during severe infection [13,14]. A physiological rise in PCT level was recorded in healthy neonates, with a peak between 18 and 30 h of life, thereafter reverting to normal between 42 and 48 h [15,16]. Additionally, a significant increase in serum PCT concentration during sepsis was found in both term neonates and a heterogeneous group of preterm neonates.…”

Section: Introductionmentioning

confidence: 99%

Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis

Janota

Straňák

Bělohlávková

et al. 2001

Eur J Clin Investigation

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Background To determine the influence of chorioamnionitis and neonatal sepsis on procalcitonin (PCT) levels in very-low-birth-weight (VLBW) infants within the first week of life.Design PCT serum levels were measured in cord blood 1 h after delivery and on day 3 and day 7 of life. Chorioamnionitis and neonatal sepsis within the first week were monitored.Results Chorioamnionitis was present in eight of 37 patients (21´6%). PCT on day 3 was increased in both the`No chorioamnionitis' (2´54 ng mL 21 , SEM 0´51) and`Chorioamnionitis' (6´96 ng mL 21 , SEM 2´93) groups of VLBW infants compared with the 1st hour values (0´45 and 0´58 ng mL 21 SEM 0´07 and 0´11, respectively, P , 0´001) of the same patients. The postnatal gain was higher in the`Chorioamnionitis' group (P , 0´01). Neonatal sepsis was diagnosed (after exclusion) in 12 of 32 patients (37´5%). Mean values of maximum PCT in patients with and without sepsis were 8´41 ng mL 21 (SEM 1´87) and 3´02 ng mL 21 (SEM 1´38), respectively (P , 0´05). Sensitivity to sepsis of PCT, ratio of immature to total neutrophils (I : T), and C-reactive protein (CRP) were 75%, 50% and 25%, respectively.Conclusions In the group of VLBW infants the PCT level within 72 h of delivery was markedly increased in patients with chorioamnionitis. Compared with I : T and CRP, PCT appears to be a more sensitive marker of neonatal sepsis.

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“…First reference levels of PCT were published in the late 1990s (17). There was evidence that 18-30 h post-partum neonates and premature babies without infection also presented with increased PCT levels (18).…”

Section: Key Notesmentioning

confidence: 99%

Procalcitonin and valuable clinical symptoms in the early detection of neonatal late‐onset bacterial infection

et al. 2011

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Arterial hypotension, feeding intolerance and especially prolonged capillary refill indicate proven neonatal late-onset bacterial infection, even at the time of first suspicion. Additional measurement of procalcitonin does indeed improve sensitivity to nearly 100%, but is linked to a decline in specificity. Nevertheless, in the high-risk neonatal population, additional procalcitonin measurement can be recommended because all infants with NBI have to be identified.

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Increased Serum Procalcitonin in Newborn Infants without Infection

Cited by 57 publications

References 4 publications

Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates

Procalcitonin in the early diagnosis of nosocomial sepsis in preterm neonates

Postnatal increase of procalcitonin in premature newborns is enhanced by chorioamnionitis and neonatal sepsis

Procalcitonin and valuable clinical symptoms in the early detection of neonatal late‐onset bacterial infection

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