Increased sexual arousal in patients with movement disorders

Teive, Hélio A.G.; Moro, Adriana; Moscovich, Mariana; Munhoz, Renato P.

doi:10.1590/0004-282x20150217

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…In 1 prospective study, 2 PD patients (both male) were identified to have HSD following bilateral STN-DBS. 76 However, it is well recognized that HSD is also observed in PD patients who have not undergone DBS surgery as a consequence of dopaminergic agonist medication and levodopa abuse. In this particular study, the adjustment of DBS parameters resulted in an improvement in HSD symptoms in at least 1 of the patients; however, it is not clear if this also coincided with medication reduction 76 (Table 5).…”

Section: Sexual Domainmentioning

confidence: 99%

“…Most notably increased sexual arousal and hypersexual disorder (HSD). In 1 prospective study, 2 PD patients (both male) were identified to have HSD following bilateral STN‐DBS . However, it is well recognized that HSD is also observed in PD patients who have not undergone DBS surgery as a consequence of dopaminergic agonist medication and levodopa abuse.…”

Section: Sexual Domainmentioning

confidence: 99%

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Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Bellini

Best

Brechany

et al. 2020

Movement Disord Clin Pract

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Background The role of deep brain stimulation (DBS) in the management of motor symptoms in patients with Parkinson's disease is well defined. However, it is becoming increasingly clear that DBS can either improve or worsen a number of non‐motor phenomena. Objectives We examined the published literature to better understand the effects on autonomic symptoms following DBS of the subthalamic nucleus and the globus pallidus interna. Methods We conducted a PubMed search of studies regarding the effects of DBS on the autonomic system published from January 2001. We searched for the following terms and their combinations: Parkinson's disease, deep brain stimulation, subthalamic nucleus, globus pallidus interna, autonomic dysfunction. Results Most studies reported in the literature focus on DBS targeting the subthalamic nucleus, with particular emphasis on favorable outcomes regarding gastrointestinal function and bladder control. However, the emergence or worsening of autonomic symptoms in subgroups of patients has also been documented. More controversial is the effect of stimulation on the cardiovascular, pulmonary, and thermo‐regulatory systems as well as sexual functioning. Data regarding the influence of DBS on the autonomic system when the target is the globus pallidus interna is less forthcoming, with target selection varying according to centre and clinical indication. Conclusions DBS appears to affect the autonomic nervous system, with varying degrees of influence, which may or may not be clinically beneficial for the patient. A better understanding of these effects could help personalize stimulation for individual patients with autonomic disorders and/or avoid autonomic symptoms in susceptible patients.

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Section: Sexual Domainmentioning

confidence: 99%

Section: Sexual Domainmentioning

confidence: 99%

Clinical Impact of Deep Brain Stimulation on the Autonomic System in Patients with Parkinson's Disease

Bellini

Best

Brechany

et al. 2020

Movement Disord Clin Pract

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“…In contrast, a significantly higher frequency of sexual dysfunction was observed in Rukmini et al's study 45 . Also, in another investigation, hypersexual disorder (HSD) was reported as a negative outcome of STN‐DBS observed in two patients 53 . Nevertheless, this can be attributed to the misuse of levodopa and dopaminergic agonist drugs.…”

Section: Discussionmentioning

confidence: 96%

“…45 Also, in another investigation, hypersexual disorder (HSD) was reported as a negative outcome of STN-DBS observed in two patients. 53 Nevertheless, this can be attributed to the misuse of levodopa and dopaminergic agonist drugs.…”

Section: Sexual Problemsmentioning

confidence: 99%

Effects of subthalamic deep brain stimulation on non‐motor symptoms of Parkinson's disease: A meta‐analysis

Eghlidos

Rahimian

Vadiee

et al. 2022

Acta Neuro Scandinavica

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Deep brain stimulation (DBS) is a well‐defined treatment for motor symptoms in advanced PD. Although several studies have investigated the DBS effect on non‐motor symptoms (NMS), controversial results exist regarding this matter. The aim of this meta‐analysis and systematic review was to assess the bilateral subthalamic nucleus (STN) DBS effect on NMS of PD. We conducted a systematic search on the literature of Web of Science (WOS), PubMed/MEDLINE, Scopus, Cochrane, and Embase. An additional hand search was also done. Finally, a meta‐analysis was conducted on 10 studies containing pre‐ and post‐bilateral STN‐DBS data regarding NMS acquired using Non‐Motor Symptoms Scale for Parkinson's Disease (NMSS) or Non‐Motor Symptoms Questionnaire (NMSQ). A random‐effects model was used to determine weighted mean differences, and the heterogeneity index was evaluated using Cochrane's Q test. Our study results indicated that bilateral STN‐DBS significantly reduced total NMSS and NMSQ score (WMD −17.73; 95% confidence interval [CI] −20.28 to −15.18, WMD −2.19; 95% CI −2.98 to −1.40), respectively, and no publication bias was found. Regarding each of the NMSS domains, DBS significantly reduced the scores of following domains: sleep (WMD ‐5.98; 95% CI ‐6.82 to −5.15), miscellaneous (WMD −4.19; 95% CI −4.96 to −3.43), urinary (WMD −2.99; 95% CI −3.78 to −2.19), sexual (WMD −0.65; 95% CI −1.16 to −0.14), and attention/memory (WMD −0.59; 95% CI −1.15 to −0.03). This meta‐analysis demonstrated that bilateral STN‐DBS has beneficial effects on NMS of PD.

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