Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus

Sawada, Shigemasa; Hashimoto, Hiroshi; Iijma, S.; Tokano, Yoshiaki; Matsukawa, Yoshihisa; Takei, Masami; Ishikawa, Hitoshi; Kang, Hoil; Tomura, Kohtaro; Mitamura, Ko; Hashimoto, Shin Ichi; Obara, Tadashi

doi:10.1007/bf02231527

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…Recent studies have identified several cytokines that play important roles in the immunopathogenesis of various immune disorders, such as SLE [19][20][21]. Other compounds, such as soluble interleukin-2 (IL-2) receptor, soluble CD4 and soluble CD8, have also been examined and are considered to play important roles in the aberrant immune function encountered in SLE [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Significance of stem cell factor and soluble KIT in patients with systemic lupus erythematosus

et al. 1998

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To determine the significance of stem cell factor (SCF) and soluble KIT (sKIT) in the serum of patients with systemic lupus erythematosus (SLE), levels of SCF and sKIT in patients with SLE were estimated, and their correlations with clinical parameters were examined. The sKIT levels in SLE patients (n = 106) were significantly lower than those in healthy controls (n = 40). A significant negative correlation was found between the SCF and sKIT levels of SLE patients. Although the SCF levels correlated with the titre of anti-RNP antibody, no significant relationship was found between SCF levels and blood cell counts, such as white blood cell, red blood cell and platelet counts. sKIT levels were significantly correlated with the platelet count, and were negatively correlated with the white blood cell count, titre of anti-DNA antibody, and SLE activity index (SLEDAI). sKIT levels were also negatively affected by high doses of corticosteroid. These results indicate that serum sKIT levels may be more closely related than SCF to the haematological abnormalities in SLE patients, and may reflect the clinical status of SLE patients and the effectiveness of high-dose corticosteroid treatment.

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Section: Introductionmentioning

confidence: 99%

Significance of stem cell factor and soluble KIT in patients with systemic lupus erythematosus

et al. 1998

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“…77 SIL-2R expression is also increased in the peripheral blood of SLE patients, especially in those experiencing discoid skin lesions. 80 It is unclear from these studies what role either the soluble or surface IL-2Rs may be playing in the wound healing problems found in SLE patients. Thus, more study of the actions of downstream IL-2R signaling and the behavior of the IL-2R are required in this context.…”

Section: Il-2 In Diseases Involving Wound Healingmentioning

confidence: 99%

The contribution of interleukin-2 to effective wound healing

Doersch

DelloStritto

Newell‐Rogers

2016

Exp Biol Med (Maywood)

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Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment. When these interactions are perturbed, wounds can be a nidus for infection, which can cause them to remain open an extended period of time, or can scar excessively. Interleukin-2, a cytokine that directs T-cell expansion and phenotypic development, appears to play an important role in wound healing. The beststudied role for Interleukin-2 is in influencing T-cell development. However, other cell types, including fibroblasts, the skin cells responsible for closing wounds, express the Interleukin-2 receptor, and therefore may respond to Interleukin-2. Studies have shown that treatment with Interleukin-2 can improve the strength of healed skin, which implicates Interleukin-2 in the wound healing process. Furthermore, diseases that involve impaired wound healing, such as diabetes and systemic lupus erythematosus, have been linked to deficiencies in Interleukin-2 or defects Interleukin-2-receptor signaling. The focus of this review is to summarize the current understanding of the role of Interleukin-2 in wound healing, to highlight diseases in which Interleukin-2 and its receptor may contribute to impaired wound healing, and to assess Interleukin-2-modulating approaches as potential therapies to improve wound healing.

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Effect of ethanol and cocaine treatment on the immune system of v-Ha-ras-transgenic mice

Chen¹,

Colombo²,

López³

et al. 1996

International Journal of Immunopharmacology

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Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus

Cited by 9 publications

References 23 publications

Significance of stem cell factor and soluble KIT in patients with systemic lupus erythematosus

Significance of stem cell factor and soluble KIT in patients with systemic lupus erythematosus

The contribution of interleukin-2 to effective wound healing

Effect of ethanol and cocaine treatment on the immune system of v-Ha-ras-transgenic mice

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