Increased spinal cord movements in cervical spondylotic myelopathy

Vavasour, Irene M.; Meyers, Sandra M.; MacMillan, Erin L.; Mädler, Burkhard; Li, David K.B.; Rauscher, Alexander; Vertinsky, Talia; Venu, Vic; MacKay, Alex L.; Curt, Armin

doi:10.1016/j.spinee.2014.01.036

Cited by 42 publications

(50 citation statements)

References 41 publications

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“…A retrospectively cardiac-gated commercially available phasecontrast sequence for craniocaudal velocity imaging was implemented (spatial resolution 0.5 × 1.1 × 5.0 mm 3 , FoV 140 × 140 mm 2 , matrix 256 × 128, TR = 11.5 ms, TE = 8.7 ms, flip angle 10°, bandwidth 488 Hz/px). Velocity encoding of the sequence was set at ±5cm/s for optimal CSF flow and spinal cord motion analysis in expectation of low CSF dynamics at level of stenosis as previously reported [3]. Phase-contrast MRI was acquired perpendicular to the spinal cord at level C2 and C5 consecutively with an acquisition time of~1.3 min per level depending on the heart rate.…”

Section: Imaging Parameters and Analysismentioning

confidence: 99%

“…This non-invasive, dynamic-diagnostic approach enabled first pathophysiological insights within a variety of diseases presenting alterations in cerebrospinal fluid (CSF) dynamics [2]. Among patients with cervical spondylotic myelopathy (CSM), several studies applying 2D PC-MRI reported decreased CSF flow at level of stenosis [3,4]. In addition, two groups focusing on spinal cord dynamics have described increased spinal cord motion at level of a cervical These authors contributed equally: Katharina Wolf, Markus Hupp.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, two groups focusing on spinal cord dynamics have described increased spinal cord motion at level of a cervical These authors contributed equally: Katharina Wolf, Markus Hupp. spinal stenosis [3,5], related to sensory deficits in one study [3]. These studies were stimulated by the need of improving the diagnostic work-up in CSM beyond clinical and anatomical (i.e., static) MRI measures by evaluating dynamic factors contributing to the development of CSM [6].…”

Section: Introductionmentioning

confidence: 99%

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In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study

et al. 2018

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Section: Imaging Parameters and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study

et al. 2018

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“…Patients with later stage cervical spondylosis may also experience difficulty in walking, hyperactive proprioceptive reflexes as well as atrophy of related muscles. [7][8][9][10] In the spinal clinical practice, patients with cervical spondylosis often complain about a set of symptoms including vertigo, tinnitus, palpitations, headache, blurred vision, hypomnesia, and nausea. They were first reported by Barré and Liéou in 1926, and this set of symptoms was also called the Barré and Liéou syndrome.…”

Section: Discussionmentioning

confidence: 99%

Effect of Anterior Cervical Discectomy and Fusion on Patients with Atypical Symptoms Related to Cervical Spondylosis

Muheremu

Sun

et al. 2016

J Neurol Surg A Cent Eur Neurosurg

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Background A considerable number of patients with cervical spondylosis complain about one or multiple atypical symptoms such as vertigo, palpitations, headache, blurred vision, hypomnesia, and/or nausea. It remains unclear whether surgical intervention for cervical spondylosis can also effectively alleviate those symptoms. The current study was performed to see if anterior cervical diskectomy and fusion (ACDF) offers such an extra benefit for patients with cervical spondylosis. Objective To investigate if patients who received ACDF for the treatment of cervical spondylotic myelopathy and/or radiculopathy can also achieve alleviation of certain atypical symptoms associated with cervical spondylosis after the surgery in the long run. Methods Sixty-seven patients who underwent ACDF for the treatment of cervical spondylotic myelopathy and/or radiculopathy were involved in this study. All these patients also complained about various associated atypical symptoms. They were followed up for 26 to 145 months after the surgery. Severity and frequency scores of the atypical symptoms before the surgery and at last follow-up were compared by paired t tests. Results Most patients reported significantly alleviated symptoms at the last follow-up compared with before the surgery. The severity of vertigo, headache, nausea, and palpitations were significantly alleviated at the last follow-up (with p values of p < 0.001, p = 0.001, p = 0.022, p = 0.004, respectively). There were no significant changes in the severity of tinnitus (p = 0.182), blurred vision (p = 0.260), and hypomnesia (p = 0.821). Conclusion ACDF can significantly alleviate vertigo, headache, nausea, and palpitations in most patients with cervical spondylotic myelopathy and/or radiculopathy, but it is not effective in alleviating symptoms such as tinnitus, blurred vision, and hypomnesia. It can be considered for alleviating atypical symptoms when other treatment options prove ineffective.

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“…15 Others show patients with spondylosis have greater cord displacement due to pulsatile CSF flow than controls. 63 Our neurosurgery collaborators have assessed the displacement of the thoracic cord during flexion using MR imaging. By using root-cord junctions as landmarks, they found the average thoracic spinal cord displacement within the canal to be 8.5 ± 6.0 mm and the average axial stretch of the cord to be 3.5 ± 2.6 mm.…”

Section: D Imaging Of Spinal Cord Using Mrimentioning

confidence: 99%

Surgical treatment for cervical myelopathy

Stoner¹

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____________________________________________ Vincent Magnottaii To Grammy, Pop-Pop, and Mom who always stressed the importance of education, hard work, and helping others.And to Brigitta, the best sister there is.iii Genius is one percent inspiration, ninety-nine percent perspiration.-Thomas Edison I just try to help my people. -Rocco Santarelli III, age 4 iv ACKNOWLEDGEMENTS I could not have completed my graduate studies without the people mentioned here. Thank you all for supporting me through the journey. I first and foremost need to thank my adviser, Dr. Nicole Grosland. She has been the best adviser I could have hoped for. She has always been available and happy to give guidance I needed. Most importantly she's taught me not to be afraid to ask questions and realize when my FE models are good enough; perfection is not the goal, answering the research question is! I also need to thank my committee member, Dr. Vincent Magnotta, who was always willing to teach and help me understand the intricacies of MR imaging, and help me with all of my coding errors! I would also like to thank Dr. Matthew Howard and Dr. Kingsley Abode-Iyamah for all of their clinical input in this project. Being able to interact directly with you, the surgeons, and patients in the neurosurgery clinic has been invaluable to my education. Thank you to Dr. Nicole Kallemeyn and Dr. David Wilder for being on my committee and always asking interesting and thought provoking questions. Dr. Nicole Watson also deserves a big thank you for all of her patience and help with my finite element models. You're the best office-mate I could ask for! Thanks to Lisa and Jenny at CCAD for always making things run smoothly! Thank you to all of the good friends I've made over the last four years. Relaxing and having fun together has made this time wonderful. Finally I need to thank my family, especially my mother and sister, for always supporting and loving me unconditionally. v ABSTRACT Cervical myelopathy is the most common form of spinal cord injury in North America with roughly 19,000 new cases in the US every year. It results from chronic compression of the spinal cord by osteophytes, intervertebral disc herniation, and ossified ligaments. It commonly affects adults over the age of 50 years and causes upper extremity numbness, loss of hand dexterity, gait disturbances, and decreased proprioception. Recent studies imaging studies have shown this injury is highly

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Increased spinal cord movements in cervical spondylotic myelopathy

Cited by 42 publications

References 41 publications

In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study

In cervical spondylotic myelopathy spinal cord motion is focally increased at the level of stenosis: a controlled cross-sectional study

Effect of Anterior Cervical Discectomy and Fusion on Patients with Atypical Symptoms Related to Cervical Spondylosis

Surgical treatment for cervical myelopathy

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