Increased storage and secretion of phosphatidylcholines by senescent human peritoneal mesothelial cells

Abstract

Senescent HPMC store and secrete substantially more PC than young cells. Our findings indicate a novel protective mechanism, which should counteract peritoneal damage induced by chronic exposure to PD fluids.

Comparative Blood and Urine Metabolomics Analysis of Healthy Elderly and Young Male Singaporeans

“…In another study, senescent human peritoneal mesothelial cells were found to store and secrete substantially more phosphatidylcholines than young cells. 56 Our results are also in agreement with another large-scale targeted metabolic profiling study 5 in which there was a significant increase in specific phosphatidylcholines and sphingomyelins. It is suggested that the elevated serum levels of phospholipid in elderly are also involved in protection against oxidative stress; 5 however, further investigation is needed to understand the mechanism involved.…”

“…Naru et al 55 found that in vitro senescent human dermal fibroblasts cells had increased levels of a particular phosphatidylcholine species. In another study, senescent human peritoneal mesothelial cells were found to store and secrete substantially more phosphatidylcholines than young cells 56 . Our results are also in agreement with another largescale targeted metabolic profiling study 5 in which there was a significant increase in specific phosphatidylcholines and sphingomyelins.…”