Increased Straylight in Patients With Keratoconjunctivitis Sicca

Wouw, Didrika Sahira van de; Meulen, Ivanka J.E. van der; Vliet, Johannes M. J. van; Lapid-Gortzak, Ruth; Nieuwendaal, Carla P.; Berg, Thomas

doi:10.1097/ico.0000000000000828

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…Further, there was no relationship between central SPK and straylight. Recently, van de Wouw et al 17 reported straylight values in patients with severe keratoconjunctivitis sicca using the same straylight meter utilized in our study. According to that study, increased straylight values were observed in patients with keratocon- junctivitis sicca and this increase was not correlated to the amount of corneal epithelial damage graded with the van Bijsterveld's scoring system, 19 which is consistent with both our previous 16 and current studies.…”

Section: Discussionmentioning

confidence: 71%

“…8 Straylight is known to be a cause of disability glare [9][10][11] and corneal pathologic conditions may produce increased straylight. 12 Decreased contrast sensitivity [13][14][15] and increased straylight 16,17 in dry eye has been reported; however, little is known about the effects of ocular surface regularity in the central corneal region on contrast sensitivity and straylight.…”

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confidence: 99%

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The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Koh

Maeda

Asonuma

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 71%

mentioning

confidence: 99%

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Koh

Maeda

Asonuma

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“… 14 , 15 , 16 , 17 , 18 Straylight in the various pathological conditions of the cornea have also been investigated previously. 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 In hereditary corneal dystrophies, there is variation in the increase in straylight depending on the type of disease. 19 In eyes with central crystalline dystrophy, straylight was markedly increased with relatively well-preserved visual acuity, while in eyes with posterior polymorphous dystrophy, straylight was not increased regardless of impaired visual acuity.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and visual function in a patient with Fish-eye disease: Quantitative measurements and optical coherence tomography

Kanai

Koh

Masuda

et al. 2018

American Journal of Ophthalmology Case Reports

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PurposeWe describe a case of fish-eye disease (FED) where the clinical features and visual function were investigated using anterior segment optical coherence tomography (OCT) and quantitative measurements.ObservationsA 36-year-old Japanese woman with FED presented with bilateral corneal opacities and visual complaints. Both contrast sensitivity and straylight were measured and OCT imaging was performed. Contrast sensitivity and straylight measurements revealed remarkably decreased visual function, despite good visual acuity. OCT demonstrated homogenously hyper-reflective corneal opacification, and a normal total corneal thickness.Conclusions and ImportanceThe findings from this case suggest that OCT is useful for analyzing the clinical features of FED, and that the quantitative measurement of visual function furthers the understanding of vision-related symptoms in FED, despite good visual acuity.

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“…Lesions of the cornea and conjunctiva may occur, affecting the integrity of the OS 1. Patients with DED may experience foreign body sensation, burning, itching and aching sensations, heavy eyes, fatigued eyes, and a decreased quality of vision, eg, stray light 4. DED may also increase the risk of infections of the OS 5.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 0.2% and 0.18% hyaluronate eye drops in patients with moderate to severe dry eye with keratitis or keratoconjunctivitis

Groß¹,

Childs²,

Piaton³

2017

OPTH

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PurposeComparison of efficacy and safety of 0.2% and 0.18% hyaluronic acid (HA) eye drops three times a day (tid) in patients with moderate to severe dry eye disease, related to keratitis or keratoconjunctivitis.Patients and methodsProspective, multicenter, randomized, single-masked, phase IIIb, noninferiority study (0.2% HA vs 0.18% HA) in two parallel groups over a period of 84 days. N=70 patients were evaluated. Primary efficacy outcome was ocular surface (OS) staining change on day 35 (D35), compared to baseline. Fluorescein and lissamine green were used for staining of cornea and conjunctiva. Secondary efficacy outcome included tear film breakup time, OS staining score on day 84 (D84), ocular comfort index, as well as patients’ and doctors’ evaluation.ResultsCompared to day 0 (D0), 0.2% HA achieved a 47.7% reduction in staining score (−3.00±2.81 [standard deviation] points, n=38 patients) at D35; 0.18% HA showed a 41.2% reduction (−2.59±2.20 [standard deviation] points, n=32 patients). Statistical analysis showed noninferiority in efficacy of 0.2% HA compared to 0.18% HA on D35. At D84, the reduction in staining score had further increased to 64.5% for 0.2% HA and to 56.4% for 0.18% HA. Both eye drops improved tear film breakup time and ocular comfort index values. Investigators and patients assessed both treatments with 5 of 7 points (Likert Scale, medians). The rate of adverse events (AE) was 2.3% for 0.2% HA and 7.1% for 0.18% HA with no serious AE.Conclusion0.2% and 0.18% HA eye drops significantly improved signs and symptoms of dry eye disease and were well tolerated with few AEs. Noninferiority of 0.2% HA compared to 0.18% HA was demonstrated for reduction of OS lesions. In some parameters, there was a nonsignificant trend in favor of 0.2% HA concentration.

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Increased Straylight in Patients With Keratoconjunctivitis Sicca

Cited by 9 publications

References 12 publications

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

The Effect of Ocular Surface Regularity on Contrast Sensitivity and Straylight in Dry Eye

Clinical features and visual function in a patient with Fish-eye disease: Quantitative measurements and optical coherence tomography

Comparison of 0.2% and 0.18% hyaluronate eye drops in patients with moderate to severe dry eye with keratitis or keratoconjunctivitis

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