Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening

Narumi, Hiroya; Yoshida, Katsuya; Hashimoto, Naotake; Umehara, Isao; Funabashi, Nobusada; Yoshida, Shouji; Komuro, Issei

doi:10.1016/j.ijcard.2008.03.044

Cited by 43 publications

(36 citation statements)

References 28 publications

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“…Furthermore, the VFA/SFA may reflect the balance of the atherogenic effect of VFA and the anti-atherogenic effect of SFA [2,3]. Narumi H. et al also suggested that the VFA/SFA ratio is a better predictor of the marker for atherosclerosis, CSWA, as compared with SFA or VFA [3], which is in agreement with a significant association between the VFA/SFA ratio and baPWV in present study.…”

supporting

confidence: 91%

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Katsuyama

Kawaguchi

Yanai

2015

International Journal of Cardiology

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supporting

confidence: 91%

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Katsuyama

Kawaguchi

Yanai

2015

International Journal of Cardiology

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“…5, 9, 15, 16, 17 Of the four risk factors assessed, only the percentage of females with high BP decreased significantly across levels of SAT, and this finding was only shown within the lowest VAT tertile. The logistic regression analyses showed that SAT was associated with increased odds of having each individual risk factor in univariate analyses and increased risk of having two or more risk factors whether or nor VAT was accounted for.…”

Section: Discussionmentioning

confidence: 94%

“…3, 7 In addition, several epidemiological studies have shown that SAT was negatively associated with risk factors for cardiometabolic disease. 5, 9, 15, 16, 17 However, these findings were evident only in the highest tertile of VAT, were seen in only one gender group (for example, males) or were seen for only one risk factor (for example, triglycerides). Such findings are consistent with the observation that, in susceptible individuals, excess fat can also be deposited ectopically in the liver, kidney, pancreas, skeletal muscles, heart and so on, 11 which leads to a decreased ability of these organs to function properly, resulting in a poor cardiometabolic profile.…”

Section: Introductionmentioning

confidence: 94%

Abdominal adiposity depots are correlates of adverse cardiometabolic risk factors in Caucasian and African-American adults

et al. 2011

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Objective:Accumulation of adipose tissue is associated with cardiometabolic risks. Although visceral adipose tissue (VAT) has been strongly implicated in this relationship, there is still some debate regarding the contribution of abdominal subcutaneous adipose tissue (SAT). The purpose of this study was to determine the contribution of abdominal SAT to cardiometabolic risk factors, independent of total and visceral adiposity. These relationships were assessed in Caucasian and African Americans.Design:It is a cross-sectional analysis of the Pennington Center Longitudinal Study.Subjects:Data were extracted from 1246 participants. Total body fat mass (FM) was measured by dual-energy X-ray absorptiometry, whereas abdominal VAT and SAT areas (cm2) were measured with computed tomography. The cardiometabolic risk factors included resting blood pressure (BP), fasting blood glucose and triglyceride concentrations and high-density lipoprotein cholesterol (HDL-C).Results:Positive relationships across tertiles of VAT were seen for the participants with high glucose, high BP and low HDL-C (P<0.043). There was also a significant increase in the percentage of participants with two or more cardiometabolic risk factors across most tertiles of abdominal SAT (P<0.042). Logistic regression analysis showed that in univariate models, all adiposity measures were significantly associated with increased odds of having all risk factors in men and women. In multivariate models, VAT was significantly associated with most risk factors across gender. Abdominal SAT and FM (odds ratios (ORs) 1.3–2.1; all P<0.05) were associated with fewer risk factors after accounting for VAT. VAT (OR=5.9 and 5.3) and SAT (OR=2.0 and 1.8) were both associated with higher odds of the presence of two or more cardiometabolic risk factors in both males and females (P<0.001).Conclusion:The data suggest that abdominal SAT is not protective against unfavorable cardiometabolic risk profiles. These conclusions were consistent across ethnic groups.

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“…In contrast, a few studies have suggested a possible beneficial role for SAT [8]. A previous study in a sample of middle-aged men and women found that higher amounts of subcutaneous abdominal fat are associated with lower levels of subclinical atherosclerosis [9]. It remains unclear if SAT may be risk enhancing or, rather, protective for CVD.…”

Section: Introductionmentioning

confidence: 99%

Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus

Jung

Kim

et al. 2014

Cardiovasc Diabetol

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BackgroundWhereas visceral abdominal adipose tissue (VAT) is associated with cardiometabolic risk, there is debate regarding the role of subcutaneous abdominal adipose tissue (SAT). The aim of this study was to investigate the relationships of subcutaneous and visceral abdominal fat with carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 234 patients (men 131, women 103, mean age: 53 years) with T2DM were enrolled. Carotid intima-media thickness (CIMT), abdominal subcutaneous fat thickness (SFT) and visceral fat thickness (VFT) were assessed by high-resolution B-mode ultrasonography (US).ResultsCompared to women, men had significantly higher VFT and lower SFT (p = 0.002, p = 0.04, respectively). In partial correlation coefficient analyses between CIMT and abdominal fat thickness after adjustment for body mass index (BMI), SFT showed a negative correlation with CIMT in men (r = -0.27, p = 0.03). VFT was not correlated with CIMT in either men or women. In women, SFT was not correlated with CIMT (r = -0.01, p = 0.93). VFT/SFT ratio was not correlated with CIMT in either men or women. In multivariate regression analyses adjusted for BMI and other CVD risk factors, SFT but not VFT was independently inversely associated with CIMT in men but not in women (p < 0.001).ConclusionsSFT assessed by US was inversely associated with carotid atherosclerosis in patients with T2DM, particularly men. Further research into the different roles of the two types of abdominal adipose tissue in both men and women is warranted.

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Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening

Cited by 43 publications

References 28 publications

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Abdominal adiposity depots are correlates of adverse cardiometabolic risk factors in Caucasian and African-American adults

Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus

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