Increased suppression of intracoronary C-myc protein synthesis within the stent or balloon injury site using an intravenous microbubble delivery system containing antisense to C-myc: Comparison with direct intracoronary injection

Porter, Thomas R.; Knapp, Derek C.; Venneri, Lucia; Oberdorfer, Joseph; Lof, John; Iversen, Patrick L.; Xie, Feng

doi:10.1016/s0735-1097(03)81290-1

Cited by 4 publications

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“…The technique by which ultrasound facilitates the delivery of drugs and genes using microbubbles can be achieved by both mechanical and thermal processes that result from a complex interplay among the therapeutic agent, the characteristics of the microbubble, the target tissue and the acoustic energy of the ultrasound. Several studies 14,[22][23][24][25][26][27][28][29][30][31][32][33][34]71 in an attempt to understand the behaviour of microbubbles under ultrasound acoustic pressure have investigated the different aspects of these mechanical and thermal processes. Dijkmans et al 25 and Tachibana and Tachibana 24 reviewed the behaviour of microbubbles in the bloodstream and under ultrasound acoustic pressure.…”

Section: Effects Of Microbubbles Under Ultrasound Acoustic Pressurementioning

confidence: 99%

“…31 As a result of this characteristic, the delivery of drugs or genes bound to albumin-coated microbubbles could be selectively concentrated at the site of vascular injury in the presence 32 or absence of ultrasound application. Porter et al 33 studied the effect of applying ultrasound on the suppression of intracoronary c-myc protein synthesis within the stent or balloon injury site of pigs using a microbubble delivery system. They intravenously injected anti c-myc bound with a perfluorocarbon containing albumin microbubbles into the coronary arteries of pigs following intracoronary stent or balloon injury.…”

Section: Therapeutic Properties Of Microbubbles Under Ultrasound Acoumentioning

confidence: 99%

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A review of ultrasound-mediated microbubbles technology for cancer therapy: a vehicle for chemotherapeutic drug delivery

Osei

Al-Asady

2019

J Radiother Pract

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Background:The unique behaviour of microbubbles under ultrasound acoustic pressure makes them useful agents for drug and gene delivery. Several studies have demonstrated the potential application of microbubbles as a non-invasive, safe and effective technique for targeted delivery of drugs and genes. The drugs can be incorporated into the microbubbles in several different approaches and then carried to the site of interest where it can be released by destruction of the microbubbles using ultrasound to achieve the required therapeutic effect.Methods:The objective of this article is to report on a review of the recent advances of ultrasound-mediated microbubbles as a vehicle for delivering drugs and genes and its potential application for the treatment of cancer.Conclusion:Ultrasound-mediated microbubble technology has the potential to significantly improve chemotherapy drug delivery to treatment sites with minimal side effects. Moreover, the technology can induce temporary and reversible changes in the permeability of cells and vessels, thereby allowing for drug delivery in a spatially localised region which can improve the efficiency of drugs with poor bioavailability due to their poor absorption, rapid metabolism and rapid systemic elimination.

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Section: Effects Of Microbubbles Under Ultrasound Acoustic Pressurementioning

confidence: 99%

Section: Therapeutic Properties Of Microbubbles Under Ultrasound Acoumentioning

confidence: 99%

A review of ultrasound-mediated microbubbles technology for cancer therapy: a vehicle for chemotherapeutic drug delivery

Osei

Al-Asady

2019

J Radiother Pract

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“…Albumin-coated microbubbles do not adhere to normally functioning endothelium, but their adherence does occur to activated endothelial cells or to extra-cellular matrix of the disrupted vascular wall, and this interaction could be a marker of endothelial integrity 46 . Because of this characteristic, the delivery of drugs or genes bound to albumin-coated microbubbles could be selectively concentrated at the site of vascular injury in the presence or absence of ultrasound application 56,57 .…”

Section: Fig 3: Incorporation Of Drug Into Microbubblesmentioning

confidence: 99%

Untitled

2012

IJPSR

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Microbubbles are bubbles smaller than one millimeter in diameter, but larger than one micrometer. Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains surfactants to control the surface properties as well as stability of the bubble. Microbubbles have an average size less than that of RBC's i.e., they are capable of penetrating even into the smallest blood capillaries & releasing drugs or genes, incorporated on their surface, under the action of ultrasound. Microbubbles in general have a wide variety of applications. However in the biomedical field these are primarily used as diagnostic agents in combination with ultrasound for molecular imaging of various organs and even tumours. These are also proposed for drug and gene delivery to targeted regions in combination with various ligands. Most of the physicians today prefer imaging with ultrasound in combination with microbubbles compared to other diagnostic techniques for low cost and rapidity. They are used in medical diagnostics as a contrast agent for ultrasound imaging. The gas-filled, e.g., air or perfluorocarbon, microbubbles oscillate and vibrate when a sonic energy field is applied and may reflect ultrasound waves. This distinguishes the microbubbles from surrounding tissues. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. In practice, because gas bubbles in liquid lack stability and would therefore quickly dissolve; microbubbles must be encapsulated with a solid shell. The shell is made from either a lipid or a protein such as Optison-microbubbles which consist of perfluoropropane gas encapsulated by a serum albumin shell. Microbubbles may also be used for drug delivery and water/waste water treatment purposes. INTRODUCTION: Microbubbles are also small spherical bubbles comprising of gas, they remain distinct from each other or separate from each other i.e. do not agglomerate, also they have their size range in micrometers usually 1-100 µm. There has been a lot of research on micro bubbles in recent years. Micro bubbles are miniature gas bubbles of less than 50 microns diameter in water. The micro bubbles, which mostly contain oxygen or air, can remain suspended in the water for an extended period. Gradually, the gas within the micro bubbles dissolves into the water and the bubbles disappear.

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“…Albumin-coated microbubbles do not adhere to normally functioning endothelium, but their adherence does occur to activated endothelial cells or to extra-cellular matrix of the disrupted vascular wall, and this interaction could be a marker of endothelial integrity [11]. Because of this characteristic, the delivery of drugs or genes bound to albumin-coated microbubbles could be selectively concentrated at the site of vascular injury in the presence [21] or absence of ultrasound application [22]. …”

Section: Introductionmentioning

confidence: 99%

“…Porter et al [22] measured the uptake of antisense to c- myc into coronary arteries using high phase liquid chromatography in pigs. Intravenous PESDA containing anti c- myc was given in the presence or absence of transthoracic 1 MHz ultrasound (0.6 W/cm 2 ).…”

Section: Introductionmentioning

confidence: 99%

The use of microbubbles to target drug delivery

Tsutsui

Xie

Porter

2004

Cardiovasc Ultrasound

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191

132

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Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions with glycocalix damage or endothelial dysfunction is another possible mechanism to deliver drugs even in the absence of ultrasound. This review focuses on the characteristics of microbubbles that give them therapeutic properties and some important aspects of ultrasound parameters that are known to influence microbubblemediated drug delivery. In addition, current studies involving this novel therapeutical application of microbubbles will be discussed.

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Increased suppression of intracoronary C-myc protein synthesis within the stent or balloon injury site using an intravenous microbubble delivery system containing antisense to C-myc: Comparison with direct intracoronary injection

Cited by 4 publications

References 0 publications

A review of ultrasound-mediated microbubbles technology for cancer therapy: a vehicle for chemotherapeutic drug delivery

A review of ultrasound-mediated microbubbles technology for cancer therapy: a vehicle for chemotherapeutic drug delivery

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The use of microbubbles to target drug delivery

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