Increased surgical stress promotes tumor metastasis

Tsuchiya, Yasunori; Sawada, Shigeaki; Yoshioka, Isaku; Ohashi, Yasukata; Matsuo, Mitsuhiro; Harimaya, Yuko; Tsukada, Kazuhiro; Saiki, Ikuo

doi:10.1067/msy.2003.141

Cited by 183 publications

(125 citation statements)

References 24 publications

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“…It has been demonstrated that the cellular and molecular changes following hepatectomy, including surgical stress responses, ischemia reperfusion injury can alter the kinetics of tumor growth and thereby contribute to recurrence [16,[62][63][64] . The factors related to the surgical stress itself represent transient changes, whereas the process of liver regeneration can act as a stronger and more sustained stimulus that promotes the growth of occult tumors and neoplastic development.…”

Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications. Key words: Hepatocellular carcinoma; Colorectal cancer; Recurrence; Liver regeneration; Hepatic progenitor cell; Epithelial to mesenchymal transition Core tip: The liver has a unique capacity for regeneration after cellular damage or partial removal of tissue, and modern liver surgery relies on this property. Liver regeneration is a complex process involving a large array of growth factors, cytokines and cells to restore hepatic mass and function. Experimental and clinical data indicate that the regeneration signals facilitate the growth of both primary and secondary liver tumors and can alter their malignant potential. This is an important mechanism underlying recurrence after liver surgery. New therapeutic strategies founded on better insight into the relationship between liver regeneration and tumor biology are needed.Shi JH, Line PD. Effect of liver regeneration on malignant hepatic tumors.

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Section: Regeneration Factors Influencing Tumor Growth and Metastasismentioning

confidence: 99%

Effect of liver regeneration on malignant hepatic tumors

Shi

Line

2014

WJG

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“…The treatment response rate in the group that received regional hyperthermia was 28.8%, compared with 12.7% in the group with chemotherapy alone (P = 0.002) [106] . During the postoperative period, immunity is suppressed by operative invasion [107] and the administration of anesthetic drugs such as opioids [108] , and it results in the encouragement of postoperative cancer metastasis [109] . Concerning the biological effect, preoperative feverrange whole-body hyperthermia was reported to augment postoperative cancer immunity by increasing the blood level of TNFα and HSP60 [77] .…”

Section: Combination Therapy With Surgerymentioning

confidence: 99%

Cancer immunity and therapy using hyperthermia with immunotherapy, radiotherapy, chemotherapy, and surgery

Yagawa¹,

Tanigawa²,

Kobayashi³

et al. 2017

JCMT

100

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Hyperthermia is a type of medical modality for cancer treatment using the biological effect of artificially induced heat. Even though the intrinsic effects of elevated body temperature in cancer tissues are poorly understood, increasing the temperature of the body has been recognized as a popular therapeutic method for tumorous lesions as well as infectious diseases since ancient times. Recently accumulated evidence has shown that hyperthermia amplifies immune responses in the body against cancer while decreasing the immune suppression and immune escape of cancer. It also shows that hyperthermia inhibits the repair of damaged cancer cells after chemotherapy or radiotherapy. These perceptions indicate that hyperthermia has potential for cancer therapy in conjunction with immunotherapy, chemotherapy, radiotherapy, and surgery. Paradoxically, the anticancer effect of hyperthermia alone has not yet been adequately exploited because deep heating techniques and devices to aggregate heat effects only in cancer tissues are difficult in practical terms. This review article focuses on the current understanding concerning cancer immunity and involvement of hyperthermia and the innate and adoptive immune system. The potential for combination therapy with hyperthermia and chemotherapy, radiotherapy, and surgery is also discussed. Key words:Hyperthermia, cancer immunity, chemosensitizer, radiosensitizer, combination cancer therapy, hyperthermic intraoperative peritoneal chemotherapy ABSTRACTArticle history:

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“…2 This is because micrometastases and scattered tumour cells may have already existed at the time of surgery, and even the best surgical technique is associated with the release of tumour cells into the blood and lymphatic streams. 3 Whether this minimal H Dong, Y Zhang, H Xi Effects of epidural anaesthesia on NKCC and cytokine response residual disease results in local or metastatic recurrence has been shown to depend largely on the body's immune status. 4 Many factors have been confirmed to contribute to perioperative immunosuppression.…”

Section: Introductionmentioning

confidence: 99%