Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection

Resende, Sarah Stela; Milagres, Vanessa Gonçalves; Chaves, Daniel Gonçalves; Fontes, Cor Jésus Fernandes; Carvalho, Luzia H.; Sousa, Taís Nóbrega de; Brito, Cristiana Ferreira Alves de

doi:10.1016/j.meegid.2017.03.001

Cited by 8 publications

(7 citation statements)

References 43 publications

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“…Our results are in accordance with a few previous studies [9, 10]. Resende et al genotyped five single nucleotide polymorphisms at the ABO gene of Brazilian Amazon patients and associated this information to hematological data, showing a relationship between blood group O and increased susceptibility to anemia in P. vivax infection [9]. A similar result was also found by Kuesap & Na-Bangchang that associated parasitemia and blood parameters indicative of anemia to ABO blood group in patients along Thailand and Myanmar [10].…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

“…It has been demonstrated that the ABO blood group system may be associated with severe disease in P. falciparum infections, being individuals with A phenotype at a higher risk to develop severe illness while those with type O erythrocytes are more likely protected [6-8]. On the other hand, an association between ABO system and P. vivax infection has not been clearly defined and a few studies conducted in this field reveal that hemoglobin levels are lower in blood type O individuals, who are more likely to develop anemia [9, 10]. Taking into account the above-mentioned and our ability to study in vitro deformability and clearance of nRBCs [5, 11], we investigated here whether there is an association between ABO blood groups and IgG and IgM autoantibody-driven destruction of nRBCs in P. vivax infection.…”

Section: Introductionmentioning

confidence: 99%

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Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

Mourão

Medeiros

Cardoso-Oliveira

et al. 2019

Preprint

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Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

Mourão

Medeiros

Cardoso-Oliveira

et al. 2019

Preprint

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“…Falciparum malaria patients with blood group O was shown to be significantly associated with protection against cerebral malaria, whereas those with blood groups A and B was significantly associated with increased risk of developing cerebral malaria in Indian population [ 14 ]. The association between ABO blood group and anemia induced by Plasmodium vivax infection was investigated in Brazilian patients and results suggested increased susceptibility to anemia in P. vivax patients with blood group O [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity

Kuesap

Na‐Bangchang

2018

Korean J Parasitol

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Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), β-thalassemia, α-thalassemia 1, α-thalassemia 2, HbE with α-thalassemia 2, and β-thalassemia with α-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.

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“…In addition, they showed that opsonisation with IgG antibodies from anaemic patients of healthy erythrocytes increased their phagocytosis and decreased their membrane flexibility [18]. The study in question did not address yet an additional difference between blood groups regarding the risk to develop anaemic and the involvement of auto-antibodies, as hinted soon by another investigation revealing that P. vivax infected individuals of blood type O showed lower levels of haemoglobin and haematocrit compared to type O patients [19].…”

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confidence: 97%

There will be blood

Häfner

2020

Microbes and Infection

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Highlight There will be blood * Keywords: Malaria ABO blood group system Anaemia Auto-antibodies * Article highlight based on "Effects of IgG and IgM autoantibodies on noninfected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia" by Luiza Carvalho Mourão et al. [15]. 1 https://www.duden.de/ueber_duden/wie-kommt-ein-wort-in-den-duden. 2 And this is also why I got banned from using German during the "describe it with one single word" round when playing TimesUp.

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Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection

Cited by 8 publications

References 43 publications

Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

Effects of IgG and IgM autoantibodies on non-infected erythrocytes is related to ABO blood group in Plasmodium vivax malaria and is associated with anemia

The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity

There will be blood

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