Increased Susceptibility to Murine Hepatitis Virus Infection by Treatment with Iron Salts

Warren, Joel; Mason, Rachel J.; Barbosa, Luiz H.; K, Gabbard; Bucy, Marvin

doi:10.3181/00379727-129-33386

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…On the other hand, many experimental procedures potentiate an existing subclinical MHV infection. Examples include co-infections with Eperythrozoon coccoides, lactate dehydrogenase-elevating virus and mouse cytomegalovirus (Kraft 1982, Rowe et al 1963, treatment with urethane, methylformamide (Braunsteiner & Friend 1954L halothane (Moudgil1973) or iron salts (Warren et al 1968) and feeding of necrogenic yeast (Ruebner & Miyai 1961) or hypercholesterolaemic (Braunwald et al 1991) diets. In addition, tumour transplantation may also induce more severe MHV disease.…”

Section: Implications For Researchmentioning

confidence: 99%

Enterotropic mouse hepatitis virus

Homberger

1997

Lab Anim

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SummaryMouse hepatitis virus (MHVI, the coronavirus of the mouse, is the most common viral pathogen in contemporary laboratory mouse colonies throughout the world. It is highly contagious with variable clinical manifestations. The majority of infections are subclinical, but can still significantly influence biological responses, thus interfering with research, mainly in the field of immunology. MHV has been intensively studied from a number of research perspectives and has become the prototype for studying the molecular biology of coronaviruses. MHV contains a single-stranded} positive-sense RNA genome ranging from 27 to 31 kb}which is divided into seven genes. Virions consist of four to five structural proteins. There are many MHV strains that vary in virulence, organotropism and cell tropism} and are constantly evolving by naturally occurring mutation and recombination. Based on pathogenesis studies MHV strains are usually grouped according to their primary tissue tropism into two biotypes: polytropic and enterotropic. Enterotropic strains of MHV replicate in the intestinal mucosa and only rarely spread to other tissues. No morphological structure of the virion has as yet been identified that is responsible for enterotropism. The course of an MHV infection is dependent on the virus strain and host factors. Generally, MHV causes an acute, self-limiting infection which is inapparent in adult mice. Neonates are highly susceptible to disease and show high mortality. In an enzootically infected colony, however, they are protected by maternally derived passive immunity. Detection of MHV infections depends on serological screening of colonies. MHV is controlled by culling and rederivation of the affected colony using hysterectomy or embryo transfer or by elimination through cessation of breeding.

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Section: Implications For Researchmentioning

confidence: 99%

Enterotropic mouse hepatitis virus

Homberger

1997

Lab Anim

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“…Lactoferrin interacts with mucosal surfaces where it aids in defense against infection and inflammation, largely due to its iron-chelating ability. Recent research shows it may offer some resistance to SARS-CoV-2 infection. , Fifty years ago, it was reported that iron stimulated the growth of the mouse hepatitis virus, another coronavirus …”

Section: Mechanisms To Subvert Host Iron Limitation Are Essential To ...mentioning

confidence: 99%

“…13,53 Fifty years ago, it was reported that iron stimulated the growth of the mouse hepatitis virus, another coronavirus. 54 2.4. Fungal Iron Metabolism.…”

Section: Mechanisms To Subvert Host Iron Limitation Are Essential To ...mentioning

confidence: 99%

Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens

et al. 2023

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The treatment of infections is becoming more difficult due to emerging resistance of pathogens to existing drugs. As such, alternative druggable targets, particularly those that are essential for microbe viability and thus make it harder to develop resistance, are desperately needed. In turn, once identified, safe and effective agents that disrupt these targets must be developed. Microbial acquisition and use of iron is a promising novel target for antimicrobial drug development. In this Review we look at the various facets of iron metabolism critical to human infection with pathogenic microbes and the various ways in which it can be targeted, altered, disrupted, and taken advantage of to halt or eliminate microbial infections. Although a variety of agents will be touched upon, the primary focus will be on the potential use of one or more gallium complexes as a new class of antimicrobial agents. In vitro and in vivo data on the activity of gallium complexes against a variety of pathogens including ESKAPE pathogens, mycobacteria, emerging viruses, and fungi will be discussed in detail, as well as pharmacokinetics, novel formulations and delivery approaches, and early human clinical results.

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Mouse Hepatitis Virus Biology and Epizootiology

Barthold

1986

Viral and Mycoplasmal of Laboratory Rodents

124

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Increased Susceptibility to Murine Hepatitis Virus Infection by Treatment with Iron Salts

Cited by 3 publications

References 2 publications

Enterotropic mouse hepatitis virus

Enterotropic mouse hepatitis virus

Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens

Mouse Hepatitis Virus Biology and Epizootiology

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