Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat

Symes, Elizabeth K.; Bender, David A.; Bowden, Jean-François; Coulson, Walter F.

doi:10.1016/0022-4731(84)90348-0

Cited by 28 publications

(13 citation statements)

References 12 publications

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“…It binds to a lysine residue in the hormone receptor protein, displacing it from binding to the hormoneresponse element on DNA, and so ending the enhancement of gene expression. Studies in experimental animals have shown that various steroid hormones are accumulated in the nucleus of target tissues to a greater extent, and for longer, in vitamin B 6 deficiency, with some evidence of enhanced end-organ responsiveness to low doses of hormones (Symes et al 1984;Bowden et al 1986;Bender, 1987). Studies with cells in culture have shown that acute vitamin B 6 depletion (addition of the antimetabolite 4-deoxypyridoxine) leads to a twofold increase in hormone-stimulated rate of expression of genes with a variety of hormone-response elements, and conversely, addition of high concentrations of pyridoxal to the culture medium results in a halving of the rate of gene expression in response to the hormones (Allgood et al 1990;Allgood & Cidlowski, 1992;Tully et al 1994).…”

Section: Metabolism and Metabolic Functions Of Vitamin Bmentioning

confidence: 99%

Non-nutritional uses of vitamin B₆

Bender

1999

Br J Nutr

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102

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Vitamin B6is a water-soluble vitamin, and is readily metabolized and excreted, so it has generally been assumed to have negligible toxicity, although at very high levels of intake it can cause peripheral nerve damage. Nutritional deficiency disease is extremely rare, although a significant proportion of the population shows biochemical evidence of inadequate status, despite apparently adequate levels of intake. The vitamin has been used to treat a wide variety of conditions, which may or may not be related to inadequate intake. In some conditions use of vitamin B6supplements has been purely empirical; in other conditions there is a reasonable physiological or metabolic mechanism to explain why supplements of the vitamin many times greater than average requirements may have therapeutic uses. However, even in such conditions there is little evidence of efficacy from properly conducted controlled trials.

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Section: Metabolism and Metabolic Functions Of Vitamin Bmentioning

confidence: 99%

Non-nutritional uses of vitamin B₆

Bender

1999

Br J Nutr

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102

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“…Previous studies in this laboratory (Holley et al 1983;Symes et al 1984;Bowden et al 1986) have demonstrated that this in vitro interaction between vitamin B, and steroidhormone receptors may indeed be physiologically and nutritionally relevant. Vitamin B, deficiency in the rat results in an increase in the uptake and relative nuclear accumulation of [3H]oestradiol in such target tissues as the uterus, liver and hypothalamus (Holley et al 1983).…”

mentioning

confidence: 77%

Effects of vitamin B₆deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats

1989

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1. In vitro, pyridoxal phosphate extracts steroid-hormone receptors from tight nuclear binding (Cidlowski & Thanassi, 1981); in vitamin B6-deficient rats there is increased and prolonged nuclear accumulation of oestradiol in the uterus and testosterone in the prostate, associated with enhanced biological responsiveness of these target tissues to steroid hormone action (Symes et al. 1984; Bowden et al. 1986).2. Slices of uterus from vitamin B6-deficient rats accumulated more [3H]oestradiol than did tissue from repleted animals. Acute repletion with vitamin B6 (0.5–1 h before killing) further increased the uptake of the steroid.3. Isolated hepatocytes from vitamin B6-deficient rats accumulated more [3H]dexamethasone than did cells from repleted animals. Pre-incubation of the hepatocytes with pyridoxal phosphate resulted in a further increase in the uptake of the steroid.4. The results suggest that in addition to the putative role of pyridoxal phosphate in releasing steroid-hormone-receptor complexes from tight nuclear binding (Cidlowski & Thanassi, 1981), vitamin B6 deficiency may also increase the concentration of steroid-hormone receptors or enzymes and other steroid-binding proteins in target tissues.

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“…Furthermore, Ebadi (1981) showed that vitamin B 6 deficiency affects gonadal function and disrupts the synthesis of follicle‐stimulating hormone, luteinising hormone and testosterone (Ebadi, 1981). A later study by Symes, Bender, Bowden, and Coulson (1984) showed that vitamin B 6 has a significant contribution in the action of testosterone and other steroid hormones, and vitamin B 6 ‐deficient male rats were found to have decreased levels of testosterone (Symes et al, 1984). Another in vivo study on male rats revealed that reduction of gonadal development, kept in constant darkness, was significantly improved upon receiving normal amounts of vitamin B 1 and vitamin B 6 , and a high amount of vitamin B 5 (Hanai & Esashi, 2012).…”

Section: Discussionmentioning

confidence: 99%

Seminal plasma vitamin B ₆ levels in men with asthenozoospermia and men with normal sperm motility, a measurement using liquid chromatography with tandem mass spectrometry

Banihani

Aljabali

2020

Andrologia

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There is growing evidence that vitamin B6 has a valuable contribution in maintaining normal sperm parameters; however, this contribution has not yet well‐identified. Here, we aimed to measure the level of seminal plasma vitamin B6 in men with asthenozoospermia compared to men with normal sperm motility. Ninety‐seven human males with asthenozoospermia and eighty‐eight human males with normal sperm motility (control) were recruited in this study. Collected semen samples were assessed for sperm motility, sperm count and semen volume. Liquid chromatography with tandem mass spectrometry was used to measure seminal plasma vitamin B6 concentrations. A highly significant difference (p < .0001) in concentrations of seminal plasma vitamin B6 was found between asthenozoospermic and control groups. Besides, no statistical correlations were found between seminal plasma vitamin B6 level and sperm motility, sperm count, semen volume and men age in both tested groups. In conclusion, men with asthenozoospermia have lower seminal plasma vitamin B6 level compared to men with normal sperm motility. Also, seminal plasma vitamin B6 was found not to be correlated with sperm motility and count, semen volume and men age in both tested groups. These results may provide new contribution in the management of male infertility.

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Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat

Cited by 28 publications

References 12 publications

Non-nutritional uses of vitamin B₆

Non-nutritional uses of vitamin B₆

Effects of vitamin B₆deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats

Seminal plasma vitamin B ₆ levels in men with asthenozoospermia and men with normal sperm motility, a measurement using liquid chromatography with tandem mass spectrometry

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Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat

Cited by 28 publications

References 12 publications

Non-nutritional uses of vitamin B6

Non-nutritional uses of vitamin B6

Effects of vitamin B6deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats

Seminal plasma vitamin B 6 levels in men with asthenozoospermia and men with normal sperm motility, a measurement using liquid chromatography with tandem mass spectrometry

Contact Info

Product

Resources

About

Non-nutritional uses of vitamin B₆

Non-nutritional uses of vitamin B₆

Effects of vitamin B₆deficiency and repletion on the uptake of steroid hormones into uterus slices and isolated liver cells of rats

Seminal plasma vitamin B ₆ levels in men with asthenozoospermia and men with normal sperm motility, a measurement using liquid chromatography with tandem mass spectrometry