Increased thrombin-antithrombin III complexes after 1 h of physical exercise

Abstract

Concentrations of thrombin-antithrombin III (TAT) complexes in plasma were previously reported to be increased after a 100-km run, while fibrinopeptide A (FPA) concentration remained unchanged. Thus, antithrombin III appears to neutralize thrombin generated during running and prevents fibrin formation. To determine the clinical relevance of these findings, we compared the effects of exhaustive running (1 h, n = 10) on the plasma concentrations of prothrombin fragments F1 and F2, TAT, FPA, and beta-thromboglobulin with the effects of recreational jogging (1 h, n = 10) and exhaustive bicycling on an ergometer (1 h, n = 8). Prothrombin fragments F1 and F2 and TAT concentrations increased significantly in each group. The most significant increase in TAT concentration was measured in the running group (from 1.72 +/- 0.49 to 3.61 +/- 1.03 ng/ml, P < 0.001). The best correlation was found between the postexercise TAT and lactate concentrations (r = 0.62, n = 28, P < 0.001). Mean FPA concentrations after exercise did not exceed normal values in any of the three groups analyzed. An increase in beta-thromboglobulin concentration was measured in the running and in the cycling group. Thus, thrombin is formed, in particular, when associated with anaerobic metabolism, and platelets are activated during high-intensity exercise.

Exercise-induced Changes in the Clotting Times and Fibrinolytic Activity during Official 1600 and 2 000 Meters Trot Races in the Standardbred Horses

“…Changes in hemostatic balance consequent upon exercise have been widely documented, but it is still unclear how hemostatic mechanisms actually respond to this stimulus in the equine species. The statistically significant increase observed for PT and aPTT during the 2000 meters competition is in disagreement with previous researches which showed the shortening of the clotting times in trained trotting horses compared to untrained subjects (Quintavalla et al 1994), according to studies on human athletes (Herren et al 1992;Ibbotson et al 1993). The lengthening of PT and aPTT has also been observed in long-distance running horses (M o nre al et al 1995), proving that data provided by literature in this field are equivocal.…”

Increased muscle volume and strength following six days of low-intensity resistance training with restricted muscle blood flow

“…No indication of activation of blood clotting mechanisms are apparent in the present study as there were no changes in circulating levels of coagulation parameters (TAT, PTF1,2 and D-dimer). In general, exercise has been shown to result in a transient, but balanced, activation of coagulation and fibrinolytic cascades [Herren et al, 1992]. TAT and PTF1,2 are increased after long duration of high-intensity (over 70% of VO 2 max) aerobic exercise, but not after highintensity resistance exercise [Weiss et al, 1998].…”

Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged Participants

“…[13][14][15][16] By including only healthy men in our study, and by matching the 2 age groups for body composition and fitness level, it was possible to show exclusive changes both at rest and after moderate exercise depending on the age.…”