Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area

Tajtáková, M; Semanová, Z; Tomková, Z; Szökeová, E; J, Majoros; Rádiková, Žofia; Seböková, E; Klimeš, I; Langer, P

doi:10.1016/j.chemosphere.2005.06.030

Cited by 79 publications

(48 citation statements)

References 13 publications

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“…For example, long-term exposure to high nitrate intake by drinking water and home-made meals from local products has been shown to result in an increased thyroid volume and an increased frequency of signs of subclinical thyroid disorders (thyroid hypoechogenicity by ultrasound, increased TSH level and positive anti-thyroid peroxidase) [45], but this relation was not found in another study where the level of alimentary nitrate intake was lower [46]. Interactions with dietary iodine intake may also exist [46].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

Turcios¹,

Lence-Anta²,

Santana³

et al. 2015

Eur Thyroid J

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Objectives: The aim of this study was to describe the thyroid volume in healthy adults by ultrasound and to correlate this volume with some anthropometric measures and other differentiated thyroid cancer risk factors. Study Design: Thyroid volume and anthropometric measures were recorded in a sample of 100 healthy adults, including 21 men and 79 women aged 18-50 years, living in a non-iodine-deficient area of Havana city. Results: The average thyroid volume was 6.6 ± 0.26 ml; it was higher in men (7.3 ml) than in women (6.4 ml; p = 0.15). In the univariate analysis, thyroid volume was correlated with all anthropometric measures, but in the multivariate analysis, body surface area was found to be the only significant anthropometric parameter. Thyroid volume was also higher in current or former smokers and in persons with blood group AB or B. Conclusion: Specific reference values of thyroid volume as a function of body surface area could be used for evaluating thyroid volume in clinical practice. The relation between body surface area and thyroid volume is coherent with what is known about the relation of thyroid volume to thyroid cancer risk, but the same is not true about the relation between thyroid volume and smoking habit.

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Section: Discussionmentioning

confidence: 99%

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

Turcios¹,

Lence-Anta²,

Santana³

et al. 2015

Eur Thyroid J

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“…(Note: “nitrate” refers to nitrate–nitrogen). Epidemiologic studies of noncancer health outcomes and high nitrate levels in drinking water have reported an increased risk of hyperthyroidism (Seffner 1995) from long-term exposure to levels between 11–61 mg/L (Tajtakova et al 2006). Drinking water nitrate at levels < 10 mg/L has been associated with insulin-dependent diabetes (IDDM; Kostraba et al 1992), whereas other studies have shown an association with IDDM at nitrate levels > 15 mg/L (Parslow et al 1997) and > 25 mg/L (van Maanen et al 2000).…”

Section: Background and Recent Developmentsmentioning

confidence: 99%

Impacts of Waste from Concentrated Animal Feeding Operations on Water Quality

Burkholder

Libra

Weyer

et al. 2007

Environ Health Perspect

399

232

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Waste from agricultural livestock operations has been a long-standing concern with respect to contamination of water resources, particularly in terms of nutrient pollution. However, the recent growth of concentrated animal feeding operations (CAFOs) presents a greater risk to water quality because of both the increased volume of waste and to contaminants that may be present (e.g., antibiotics and other veterinary drugs) that may have both environmental and public health importance. Based on available data, generally accepted livestock waste management practices do not adequately or effectively protect water resources from contamination with excessive nutrients, microbial pathogens, and pharmaceuticals present in the waste. Impacts on surface water sources and wildlife have been documented in many agricultural areas in the United States. Potential impacts on human and environmental health from long-term inadvertent exposure to water contaminated with pharmaceuticals and other compounds are a growing public concern. This work-group, which is part of the Conference on Environmental Health Impacts of Concentrated Animal Feeding Operations: Anticipating Hazards—Searching for Solutions, identified needs for rigorous ecosystem monitoring in the vicinity of CAFOs and for improved characterization of major toxicants affecting the environment and human health. Last, there is a need to promote and enforce best practices to minimize inputs of nutrients and toxicants from CAFOs into freshwater and marine ecosystems.

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“…The EPA defined the maximum contaminant level at 10 mg/L or 10 ppm [112]. Exposure to high levels of nitrates due to polluted water has been shown to cause thyroid dysfunction and goiter [122,123]. …”

Section: Introductionmentioning

confidence: 99%

Iodide transport: implications for health and disease

Pesce

Kopp

2014

Int J Pediatr Endocrinol

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Disorders of the thyroid gland are among the most common conditions diagnosed and managed by pediatric endocrinologists. Thyroid hormone synthesis depends on normal iodide transport and knowledge of its regulation is fundamental to understand the etiology and management of congenital and acquired thyroid conditions such as hypothyroidism and hyperthyroidism. The ability of the thyroid to concentrate iodine is also widely used as a tool for the diagnosis of thyroid diseases and in the management and follow up of the most common type of endocrine cancers: papillary and follicular thyroid cancer. More recently, the regulation of iodide transport has also been the center of attention to improve the management of poorly differentiated thyroid cancer. Iodine deficiency disorders (goiter, impaired mental development) due to insufficient nutritional intake remain a universal public health problem. Thyroid function can also be influenced by medications that contain iodide or interfere with iodide metabolism such as iodinated contrast agents, povidone, lithium and amiodarone. In addition, some environmental pollutants such as perchlorate, thiocyanate and nitrates may affect iodide transport. Furthermore, nuclear accidents increase the risk of developing thyroid cancer and the therapy used to prevent exposure to these isotopes relies on the ability of the thyroid to concentrate iodine. The array of disorders involving iodide transport affect individuals during the whole life span and, if undiagnosed or improperly managed, they can have a profound impact on growth, metabolism, cognitive development and quality of life.

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Increased thyroid volume and frequency of thyroid disorders signs in schoolchildren from nitrate polluted area

Cited by 79 publications

References 13 publications

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

Thyroid Volume and Its Relation to Anthropometric Measures in a Healthy Cuban Population

Impacts of Waste from Concentrated Animal Feeding Operations on Water Quality

Iodide transport: implications for health and disease

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