Increased Tissue Diffusion of Oxaliplatin During Laparoscopically Assisted Versus Open Heated Intraoperative Intraperitoneal Chemotherapy (HIPEC)

Thomas, Fabienne; Ferron, Gwénaël; Gesson-Paute, Amélie; Hristova, Maria; Lochon, Isabelle; Chatelut, Étienne

doi:10.1245/s10434-008-0115-8

Cited by 37 publications

(20 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10 The enhancing effect of pressure on the penetration of oxaliplatin has also been suggested in an experimental study of laparoscopic HIPEC. 24,25 Interestingly, according to our results, the effect of pressure is more marked in the parietal peritoneum (although also present in the viscera), whereas the effect of hyperthermia is more marked in the visceral peritoneum. This suggests that the 2 techniques complement each other to optimize the effect of intraperitoneal chemotherapy and offer a global treatment for peritoneal carcinomatosis.…”

Section: Tissue Concentration Of Oxaliplatinsupporting

confidence: 72%

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Facy

Samman²,

Magnin

et al. 2012

Annals of Surgery

View full text Add to dashboard Cite

show abstract

Section: Tissue Concentration Of Oxaliplatinsupporting

confidence: 72%

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Facy

Samman²,

Magnin

et al. 2012

Annals of Surgery

View full text Add to dashboard Cite

show abstract

“…Animal experiments confirmed the increased intratumoral accumulation of intraperitoneal chemotherapy when the intra-abdominal pressure was raised during HIPEC [39,40]. Gesson-Paute and coworkers reported in a pig model that increased intra-abdominal pressure during laparoscopic HIPEC as compared to open HIPEC facilitated drug penetration into the plasma compartment and peritoneal tissues [41,42]. The question remains if increased chemotherapy penetration into tumor nodules is the underlying mechanism explaining efficacy of laparoscopic HIPEC in palliating malignant ascites.…”

Section: Pharmacokinetic Rationalementioning

confidence: 85%

Laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) in the management of refractory malignant ascites: A multi‐institutional retrospective analysis in 52 patients

Valle¹,

Speeten

Garofalo³

2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

Malignant ascites is a debilitating condition affecting cancer patients in their terminal stage of disease. Recently, laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) was introduced as a new approach. From September 2001 to August 2008, 52 patients were treated with this new modality. No treatment-related mortality was observed. Median survival was 98 days. One patient developed a clinical recurrence. Laparoscopic HIPEC is a safe and effective method for palliating malignant ascites.

show abstract

“…Furthermore, laparoscopic HIPEC allows for the better penetration of drugs in peritoneal tumors than HIPEC under laparotomy and the peritoneum because closed HIPEC generates a high intraperitoneal pressure than HIPEC under laparotomy (Thomas, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of Laparosopic Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis from Gastric Cancer

Yonemura¹,

Canbay²,

Sako³

et al. 2014

CCO

View full text Add to dashboard Cite

Background: The purpose of this manuscript is to report the direct effects of hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer-patients with peritoneal metastasis (PM). Materials and Methods:Thirty-five patients with PM were enrolled, and were treated with neoadjuvant laparoscopic HIPEC (LHIPEC). LHIPEC was performed at 42 to 43 centigrade for 60 minutes adding 3 liter of saline plus 12.5mg/m2 of Mitomycin C with Cisplatin (50mg/m 2 ). Second session of LHIPEC was done one month after the first LHIPEC in all cases. At the second session of LHIPEC, ascites volume, peritoneal cytology and peritoneal cancer index (PCI) were examined again.Results: Intraoperative complications of bowel injury were experienced in one and three at 1 st and 2 nd session of laparoscopy, respectively. There was no mortality after LHIPEC. Ascites was completely disappeared in 17 of 34 patients at the second session of laparoscopy. PFCCs had been detected in 28 (80.0%) patients at the 1 st session, and the positive cytology changed to be negative in 16 (57.1%) of 28 patients at the second session. PCI at the 2 nd session (12.5 ± 10.5) was significantly lower than that at the 1 st session (16.8 ± 9.6) (P=0.023). PCI levels at the 2 nd session changed to be 0 in 6 patients. Conclusion:This new method is not only a safe and convenient method for predicting feasibility of complete cytoredution, but also an effective treatment to control malignant ascites and to eradicate PFCCs before cytoreductive surgery. Furthermore, LHIPEC can reduce PCI levels.

show abstract

Increased Tissue Diffusion of Oxaliplatin During Laparoscopically Assisted Versus Open Heated Intraoperative Intraperitoneal Chemotherapy (HIPEC)

Cited by 37 publications

References 4 publications

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

High Pressure Enhances the Effect of Hyperthermia in Intraperitoneal Chemotherapy With Oxaliplatin

Laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) in the management of refractory malignant ascites: A multi‐institutional retrospective analysis in 52 patients

Effects of Laparosopic Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastasis from Gastric Cancer

Contact Info

Product

Resources

About