Increased titer of anti-β2-glycoprotein I IgG antibody among factor V Leiden carriers during oral contraceptive use

Póka, Ròbert; Vad, Szilvia; Lakos, Gabriella; Bereczki, Zoltán; Kiss, Emese; Sipka, Sándor

doi:10.1016/j.contraception.2003.08.016

Cited by 4 publications

(5 citation statements)

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“…It would also predict that in humans, the FVL genotype is likely to be associated with higher levels of aPL and perhaps also APS. One report has indeed found increased levels of aPL antibodies in women with FVL taking oral contraception [39]. Another report presented detailed tables of the data from which it was possible to calculate the proportion of APS markers in large groups of patients with FVL compared with normal controls [40].…”

Section: Discussionmentioning

confidence: 99%

Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice

Katzav

Grigoriadis

Ebert³

et al. 2013

BMC Med

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BackgroundWe investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation.MethodseAPS was induced in heterozygous and homozygous FVL transgenic mice (C57BL/6 background) by immunization with β2-glycoprotein I (β2-GPI). Autoantibody levels were measured at 1 and 5 months post-immunization. Mice were tested at 4 months post-immunization for behavior and cognitive function in the staircase, elevated plus-maze, and swim T-maze tests. Brains were removed and analyzed by immunohistochemistry for inflammatory markers and neurodegenerative processes.ResultsA single immunization with β2-GPI induced significantly higher and longer-lasting immune responses, and this was dependent on the number of FVL alleles. At 1 and 5 months post-immunization, levels of antibodies rose from 1.17 ± 0.07 to 1.62 ± 0.17 (optical density units; ODU) in homozygous FVL mice, compared with stable levels of 0.59 ± 0.17 and 0.48 ± 0.16 ODU in heterozygous FVL mice and a drop from 1.62 ± 0.21 to 0.61 ± 0.13 ODU in wild-type mice. Behavioral and cognitive clinical features of eAPS were also correlated with FVL allele load, as assessed by the elevated plus-maze (altered anxiety), staircase (hyperactivity and higher exploration), and swim T-maze (impaired learning) tests. Histological studies identified significant neurodegenerative changes in both grey and white matter in the eAPS-FVL brains. In spite of the potential interaction of two prothrombotic disease states, there were no ischemic lesions seen in this group.ConclusionsThe results indicate that genetically mediated coagulopathies increase the risk of developing coagulation-targeted autoimmune responses, and suggest the importance of antibody-mediated neurodegenerative processes in the brain in APS.

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Section: Discussionmentioning

confidence: 99%

Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice

Katzav

Grigoriadis

Ebert³

et al. 2013

BMC Med

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“…However, dietary lithium, which has received scant attention, is found in grains and vegetables, and to some extent animal-derived foods. 2 Hence, considering only lithium in drinking water may not be enough of a link to suicide rates. Dietary sources of lithium may actually have made the difference rather than just the drinking water.…”

Section: Lithium In Drinking Water and Food And Risk Of Suicidementioning

confidence: 99%

“…dietary lithium was reported to be: 1560 mg/day (980) in China; 1485 (1009) (Tijuana) and 939 (928) (Culiacan) in Mexico; 1090 (324) in Sweden; 1009 (324) in Denmark; 821 (684) (Texas), 650 (740) (New York) and 429 (116) (San Diego) in the USA; 812 (383) in Japan; 406 (383) in Germany; and 348 (290) in Austria. 2 Therefore, at the next stage, it would seem necessary to measure serum lithium levels in participants, incorporating total lithium intake of both drinking water and food. Psychosis and catatonia as a first presentation of antiphospholipid syndrome…”

Section: Lithium In Drinking Water and Food And Risk Of Suicidementioning

confidence: 99%

“…Oral contraceptives can exacerbate antiphospholipid syndrome; oral contraceptive use and antiphospholipid antibodies may be associated, but primarily for anti-b 2 -glycoprotein-1 antibodies. 2 Phenothiazines can induce antiphospholipid antibodies, but this has not been reported after quetiapine, olanzapine, or haloperidol. Although our patient may represent the first such occurrence, the spontaneous inflammation suggests an alternative interpretation.…”

Section: Lithium In Drinking Water and Food And Risk Of Suicidementioning

confidence: 99%

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Authors' reply

Terao¹,

Ohgami

Shiotsuki

et al. 2009

Br J Psychiatry

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“…Oral contraceptives can exacerbate antiphospholipid syndrome; oral contraceptive use and antiphospholipid antibodies may be associated, but primarily for anti-β 2 -glycoprotein-1 antibodies. 2 Phenothiazines can induce antiphospholipid antibodies, but this has not been reported after quetiapine, olanzapine, or haloperidol. Although our patient may represent the first such occurrence, the spontaneous inflammation suggests an alternative interpretation.…”

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confidence: 99%