Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas

García-Brito, Soleil; Aldavert-Vera, Laura; Huguet, Gemma; Alvarez, A.; Kádár, Elisabet; Segura-Torres, Pilar

doi:10.1016/j.bbr.2018.05.028

Cited by 7 publications

(6 citation statements)

References 63 publications

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“…Since no side effects were observed, our results suggest that the posttraining infusion of SB-334867 into the lateral ventricle resulted in a marked impairment to the acquisition and retention of both the spatial and SVD memory tasks, possibly through interfering in the consolidation of the memory. This outcome corroborates what previous studies have also reported regarding the detrimental effect of OX1R blockade on the performance in explicit (Akbari et al, 2006;Akbari et al, 2007;Yang et al, 2013;Zhao et al, 2014;García-Brito et al, 2018) and implicit (Jaeger et al, 2002;Akbari et al, 2008;Mavanji et al, 2017) memory tasks.…”

Section: Ox1r Blockade Impairs Memorysupporting

confidence: 92%

“…In addition, there is evidence of impairment of spatial memory consolidation after hippocampal administration of SB- (Soya et al, 2013). Although OX1R blockade does not seem to impair ICSS's boosting effect on consolidation in the spatial task in our study, this could be due to the higher level of training, which has been shown to improve spatial memory in SB-334867 infused rats (García-Brito et al, 2018).…”

Section: Effects Of Ox1r Blockade On Memory Facilitation By Icsscontrasting

confidence: 66%

“…shown by a c-Fos expression reduction in prelimbic and retrosplenial cortices, as well as in some thalamic nuclei and hippocampal areas of spatial-memory-impaired rats after receiving the same OX1R antagonist (García-Brito et al, 2018).…”

Section: Ox1r Blockade Impairs Memorymentioning

confidence: 98%

“…Orexin-A binds with high affinity to OX1R (Sakurai et al, 1998), which is expressed widely throughout memory-related areas in the brain (Trivedi et al, 1998;Hervieu et al, 2001;Marcus et al, 2001), including CA1, DG and CA2 of the hippocampus (HPC), the prefrontal cortex (PFC) and retrosplenial cortex (RSC), and the administration of SB-334867 can result in reduced c-Fos expression in the above-mentioned areas (García-Brito et al, 2018). In addition, several studies have described how the selective blockade of OX1R can impair a spatial task in the Morris Water Maze (MWM) (Akbari et al, 2006;Akbari, et al, 2007;García-Brito et al, 2018), while orexin-A administration to rodents has been reported to have facilitative effects on passive avoidance (Jaeger et al, 2002;Telegdy & Adamik, 2002) and spatial (Zhao et al, 2014) memory tasks. Furthermore, an increase in perseverative errors has been observed in discrimination tasks after the blockade of OX1R in the basal forebrain (BF) (Piantadosi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

García-Brito

Aldavert-Vera

Huguet

et al. 2020

Neurobiology of Learning and Memory

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Enclosed is a copy of the revised manuscript entitled: Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation (NLM-19-203R1) that we submit for consideration for publication after careful revision in Neurobiology of Learning and Memory.We would like to thank the editor as well as the reviewers for their valuable time and useful contribution. Their inputs are appreciated and will definitely help improve the manuscript. You will find the response to the reviewers in a separate document attached in the submission.The article is a research paper that evaluates whether the orexinergic system is involved in the facilitation on memory by intracranial self-stimulation (ICSS). The results show that blocking the Orexin-1 receptor by SB-334867 intracerebroventricular microinfusion hinders the facilitative effects of ICSS on memory at different levels, depending on the type of memory task. Our results also suggest that ICSS can still compensate for the detrimental effects blocking the OX1R have on both spatial and discrimination memory.Overall, the outcome of the research paper suggests that the orexinergic system is one of the neurochemical systems involved in the facilitation of memory by ICSS. Furthermore, it confirms that ICSS is a treatment capable of recovering performance in memory tasks after impairment of normal function.The paper has been seen and approved by all the listed authors.

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Section: Ox1r Blockade Impairs Memorysupporting

confidence: 92%

Section: Effects Of Ox1r Blockade On Memory Facilitation By Icsscontrasting

confidence: 66%

Section: Ox1r Blockade Impairs Memorymentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

García-Brito

Aldavert-Vera

Huguet

et al. 2020

Neurobiology of Learning and Memory

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“…Make the task more difficult by reducing the number of trials per session (from 6 to 4 or to 2), or by reducing the number of the total sessions performed ( Chamorro-López et al, 2015 ; García-Brito et al, 2018 ).…”

Section: Troubleshootingmentioning

confidence: 99%

Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration

Vila-Soles

García-Brito

Aldavert-Vera

et al. 2022

Front. Behav. Neurosci.

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Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. Rewarding post-training ICSS of the medial forebrain bundle (MFB), an important system of the BRS, has been shown to consistently improve rats’ acquisition and retention in several learning tasks. In the clinical setting, deep brain stimulation (DBS) of different targets is currently being used to palliate the memory impairment that occurs in some neurodegenerative diseases. However, the stimulation of the MFB has only been used to treat emotional alterations, not memory disorders. Since DBS stimulation treatments in humans are exclusively administered by external sources, studies comparing the efficacy of that form of application to a self-administered stimulation are key to the translationality of ICSS. This protocol compares self-administered (ICSS) and experimenter-administered (EAS) stimulation of the MFB on the spatial Morris Water Maze task (MWM). c-Fos immunohistochemistry procedure was carried out to evaluate neural activation after retention. Results show that the stimulation of the MFB improves the MWM task regardless of the form of administration, although some differences in c-Fos expression were found. Present results suggest that MFB-ICSS is a valid animal model to study the effects of MFB electrical stimulation on memory, which could guide clinical applications of DBS. The present protocol is a useful guide for establishing ICSS behavior in rats, which could be used as a learning and memory-modulating treatment.

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Withdrawn: The altered dynamic community structure for adaptive adjustment in stroke patients with multidomain cognitive impairments: A multilayer network analysis

Wang,

Han,

Wang

et al. 2024

Computers in Biology and Medicine

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Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas

Cited by 7 publications

References 63 publications

Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration

Withdrawn: The altered dynamic community structure for adaptive adjustment in stroke patients with multidomain cognitive impairments: A multilayer network analysis

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