Increased Triglyceride Levels in a Japanese Population Living in Southern Brazil

Parzianello, Leandro; Parzianello, Nivaldo A.; Coelho, Janice Carneiro

doi:10.1016/j.arcmed.2004.11.004

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…We have shown that Japanese descendants living in Brazil have a lipid profile that is different from non-Japanese controls (2). They have a higher tendency to develop isquemic heart disease and have increased TG, TC and low-density lipoprotein (LDL) levels and low HDL levels.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein CIII polymorphism and triglyceride levels of a Japanese population living in Southern Brazil

Parzianello

Oliveira

Coelho

2008

Braz J Med Biol Res

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Apolipoprotein CIII (apo-CIII) participates in the regulation of triglyceride-rich lipoprotein metabolism. Several polymorphic sites have been detected within and around the apo-CIII gene. Here, we examined the relationship between apo-CIII Sst I polymorphism (CC, CG, GG genotypes) and plasma triglyceride (TG) levels in a group of 159 Japanese individuals living in Southern Brazil. The sample was divided into a group of Japanese descendants (N = 51) with high TG (HTG; >200 mg/dL) and a group of Japanese descendants (N = 108) with normal TG (NTG; <200 mg/dL). TG and total cholesterol levels were analyzed by an enzymatic method using the Labtest-Diagnostic kit and high-and low-density lipoproteins by a direct method using the Labtest-Diagnostic kit and DiaSys Diagnostic System International kit, respectively. A 428-bp sequence of apo-CIII gene was amplified using oligonucleotide primers 5' GGT GAC CGA TGG CTT CAG TTC CCT GA 3' and 5' CAG AAG GTG GAT AGA GCG CTG GCC T 3'. The PCR products were digested with a restriction endonuclease Sst I. Rare G allele was highly prevalent in our study population (0.416) compared to Caucasians (0.00-0.11). G allele was almost two times more prevalent in the HTG group compared to the NTG group (P < 0.001). The genotype distribution was consistent with the Hardy-Weinberg equilibrium. There was a significant association between rare G allele and HTG in Japanese individuals living in Southern Brazil as indicated by one-way ANOVA, P < 0.05.

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Section: Introductionmentioning

confidence: 99%

Apolipoprotein CIII polymorphism and triglyceride levels of a Japanese population living in Southern Brazil

Parzianello

Oliveira

Coelho

2008

Braz J Med Biol Res

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“…Non-participants may have different characteristics and health status than the participants. Nonetheless, several studies have shown important evidence of the role of cultural environment on an immigrant's health and lifestyle using a similar recruiting procedure to that of the present study (Evenson et al, 2002;Klatsky and Armstrong, 1991;Kudo et al, 2000;Misra et al, 2005;Namekata et al, 1997;Parzaianello et al, 2005). Second, individuals in the JB-J group were significantly younger than those in the other two groups.…”

Section: Discussionmentioning

confidence: 43%

Central Obesity and Health-related Factors among Middle-aged Men: a Comparison among Native Japanese and Japanese-Brazilians Residing in Brazil and Japan

Schwingel

Nakata

Ito

et al. 2007

J Physiol Anthropol

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The objective of this study was to investigate the influence of different cultural environments on the development of obesity by examining the association of central obesity, lifestyle, and selected coronary risk factors among people with identical Japanese genetic backgrounds living in Japan and Brazil. One hundred and four native Japanese and 286 Japanese-Brazilians residing in Brazil and Japan aged 35 years or over were studied. Obesity, metabolic risk factors for coronary disease, and history of regular sports activity, daily physical activity, and eating habits were assessed. The results showed Japanese-Brazilians residing in Brazil with significantly higher waist circumference values, and greater prevalence of central obesity compared to native Japanese and JapaneseBrazilians residing in Japan. The risk of developing central obesity was found to be 2.8 times higher among JapaneseBrazilians residing in Brazil. However, this association was no longer found to be significant after adjusting for lifestyle factors in the logistic model. Additionally, waist circumference was found to be significantly associated with metabolic risk factors for coronary disease. These findings suggest substantial variation in measures of central obesity among the three groups of Japanese ancestry, and underscore the heterogeneity of risk factors among communities of Japanese ancestry living in different cultural environments. The results also suggest that immigrant men exposed to the Brazilian cultural environment are more susceptible to the development of central obesity, and it seems to be associated with various lifestyle items and metabolic risk factors for coronary disease.

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“…genetic and environmental) contributing to its etiology [ 4 ]. High hypertriglyceridemic susceptibility in the Japanese population has been reported [ 5 6 ]. Japanese showing more favorable lipid profiles may benefit from interactions etween genetic background and environmental factors, such as diet, excise, and lifestyle [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The interaction ofApolipoprotein A5gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese

Yamasaki

Mutombo

et al. 2015

Nutr Res Pract

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BACKGROUND/OBJECTIVEApolipoprotein A5 gene promoter region T-1131C polymorphism (APOA5 T-1131C) is known to be associated with elevated plasma TG levels, although little is known of the influence of the interaction between APOA5 T-1131C and lifestyle modification on TG levels. To investigate this matter, we studied APOA5 T-1131C and plasma TG levels of subjects participating in a three-month lifestyle modification program.SUBJECTS/METHODSA three-month lifestyle modification program was conducted with 297 participants (Age: 57 ± 8 years) in Izumo City, Japan, from 2001-2007. Changes in energy balance (the difference between energy intake and energy expenditure) and BMI were used to evaluate the participants' responses to the lifestyle modification.RESULTSEven after adjusting for confounding factors, plasma TG levels were significantly different at baseline among three genotype subgroups: TT, 126 ± 68 mg/dl; TC, 134 ± 74 mg/dl; and CC, 172 ± 101 mg/dl. Lifestyle modification resulted in significant reductions in plasma TG levels in the TT, TC, and CC genotype subgroups: -21.9 ± 61.0 mg/dl, -20.9 ± 51.0 mg/dl, and -42.6 ± 78.5 mg/dl, respectively, with no significant differences between them. In a stepwise regression analysis, age, APOA5 T-1131C, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and the 18:1/18:0 ratio showed independent association with plasma TG levels at baseline. In a general linear model analysis, APOA5 T-1131C C-allele carriers showed significantly greater TG reduction with decreased energy balance than wild type carriers after adjustment for age, gender, and baseline plasma TG levels.CONCLUSIONSThe genetic effects of APOA5 T-1131C independently affected plasma TG levels. However, lifestyle modification was effective in significantly reducing plasma TG levels despite the APOA5 T-1131C genotype background.

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Increased Triglyceride Levels in a Japanese Population Living in Southern Brazil

Cited by 3 publications

References 24 publications

Apolipoprotein CIII polymorphism and triglyceride levels of a Japanese population living in Southern Brazil

Apolipoprotein CIII polymorphism and triglyceride levels of a Japanese population living in Southern Brazil

Central Obesity and Health-related Factors among Middle-aged Men: a Comparison among Native Japanese and Japanese-Brazilians Residing in Brazil and Japan

The interaction ofApolipoprotein A5gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese

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