Increased triglyceride levels in shift workers

Romon, Monique; Nuttens, M C; Fiévet, Catherine; Pot, Philippe; Bard, Jean‐Marie; Furon, D; Fruchart, Jean Charles

doi:10.1016/0002-9343(92)90230-9

Cited by 102 publications

(107 citation statements)

References 14 publications

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“…These results are apparently in contrast with previous studies showing higher plasma levels of total cholesterol [20][21][22] and triglycerides 5,21,23,24 in shift workers. Since this is the first study performed in a Mediterranean area, it may well be that different dietary habits or genetic factors linked to geographical origin of the study subjects may be responsible for the lack of this difference.…”

Section: Shift Work and Body Fatness L Di Lorenzo Et Alcontrasting

confidence: 99%

“…[16][17][18][19] Moreover, abdominal fat accumulation is a cardiovascular risk factor stronger than obesity itself, 14 and it is noteworthy that shift workers have been shown to have higher waist-to-hip ratio (WHR) (ie more central fat) than day workers, independently of body mass index (BMI). 20 Among several well known cardiovascular risk factors, total cholesterol [20][21][22] and triglycerides 5,21,23,24 have been shown to be higher in shift workers than in day workers, independently of other lifestyle factors. 20 Significant elevations in the serum levels of cholesterol, glucose, uric acid, and potassium have been reported during the first week after a night shift, and this impairment could not be explained by changes in dietary habits or other lifestyle variables.…”

Section: Introductionmentioning

confidence: 99%

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Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

et al. 2003

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OBJECTIVE:To examine the influence of shift work on metabolic and cardiovascular risk factors in subjects working in an industry sited in Apulia, Southern Italy. DESIGN: Cross-sectional study of metabolic effects of shift work in glucose tolerant workers in a chemical industry in southern Italy. SUBJECTS: The subjects included 319 glucose tolerant male individuals, aged 35-60 y. MEASUREMENTS: Anthropometric parameters (body mass index (BMI) and waist-to-hip ratio (WHR)), fasting concentrations of glucose, insulin, and lipids (total cholesterol, HDL-cholesterol, triglycerides), the sum of glucose levels during 75 g-oral glucose tolerance test (S-OGTT), and systolic and diastolic blood pressure (SBP and DBP, respectively). RESULTS: The prevalence of obesity was higher among shift workers compared to day workers, whereas body fat distribution was not different between the two groups. Shift workers had higher BMI than day workers, and shift working was associated with BMI, independently of age and work duration. Shift workers had significantly higher SBP levels, which were independently influenced by BMI, but not by shift work, thus suggesting that the difference in SBP may well be mediated by the increased body fatness. CONCLUSION: In workers of an industry sited in Southern Italy, shift work may be directly responsible for increased body fatness and is indirectly associated with higher blood pressure levels and some features of metabolic syndrome.

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Section: Shift Work and Body Fatness L Di Lorenzo Et Alcontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

et al. 2003

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“…workers (Romon et al 1992), the findings of this study may provide a partial explanation for the increased occurrence of coronary heart disease reported in shift workers.…”

Section: Figuresupporting

confidence: 48%

Altered postprandial hormone and metabolic responses in a simulated shift work environment

Ribeiro¹,

Hampton²,

Morgan³

et al. 1998

Journal of Endocrinology

138

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The circadian rhythms of most night shift workers do not adapt fully to the imposed behavioural schedule, and this factor is considered to be responsible for many of the reported health problems. One way in which such disturbances might be mediated is through inappropriate hormonal and metabolic responses to meals, on the night shift.Twelve healthy subjects (four males and eight females) were studied on three occasions at the same clock time (1330 h), but at different body clock times, after consuming test meals, first in their normal environment, secondly after a forced 9 h phase advance (body clock time approximately 2230 h) and then again 2 days later in the normal environment. They were given a low-fat pre-meal at 0800 h, then a test meal at 1330 h with blood sampling for the following 9 h. Parameters measured included plasma glucose, non-esterified fatty acids (NEFAs), triacylglycerol (TAG), insulin, C-peptide, proinsulin and glucosedependent insulinotropic polypeptide, and urinary 6-sulphatoxymelatonin.In contrast with a previous study with a high-fat premeal, postprandial glucose and insulin responses were not affected by the phase shift. However, basal plasma NEFAs were lower immediately after the phase shift (P<0·05). Incremental (difference from basal) TAG responses were significantly higher (P<0·05) immediately after the phase shift compared with before. Two-day post-phase shift responses showed partial reversion to baseline values.This study suggests that it takes at least 2 days to adapt to eating meals on a simulated night shift, and that the nutritional content of the pre-meals consumed can have a marked effect on postprandial responses during a simulated phase shift. Such findings may provide a partial explanation for the increased occurrence of cardiovascular disease reported in shift workers.

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“…Rosmond et al 5 also reported signi®cantly elevated BMI values whereas Niedhammer et al 7 reported a signi®cantly elevated prevalence of overweight among nurses working nights compared to controls working in daytime. Other studies reported no signi®cant elevation of BMI 8,9 or prevalence of overweight 10 for shiftworkers. Since an effect of shiftwork on body composition may have a considerable time lag, current shiftwork may be less relevant in this respect than a history of shiftwork.…”

Section: Introductionmentioning

confidence: 92%

Duration of shiftwork related to body mass index and waist to hip ratio

1999

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OBJECTIVE: An elevated cardiovascular disease risk for shiftworkers has frequently been reported, however, the mechanism is still unknown. Changes in eating habits, in physical activity or metabolic factors could be involved. In this study we assessed the relationship between body mass index (BMI) as a possible indicator of changed eating habits or metabolic involvement and duration of shiftwork. DESIGN: Data from an ongoing cohort study among 377 shiftworkers and non-shiftworking controls, all starting in a new job were used. Anthropometric measurements were carried out at the start of the assignment. Job history was obtained by a questionnaire. RESULTS: A positive relationship was observed between BMI and waist to hip ratio (WHR) and duration of shiftwork experience, with an adjustment for age. The linear regression coef®cients, with additional adjustments for sex, smoking status, physical activity and educational level were 0.12 kgam 2 per y in shiftwork for BMI (P`0.05) and 0.0016 per y in shiftwork for WHR (P`0.05). CONCLUSIONS: These results suggest a relationship between years worked in shifts with BMI and WHR for both males and females. Whether this might re¯ect an effect of changed dietary habits or a metabolic effect is not yet clear.

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Increased triglyceride levels in shift workers

Cited by 102 publications

References 14 publications

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Altered postprandial hormone and metabolic responses in a simulated shift work environment

Duration of shiftwork related to body mass index and waist to hip ratio

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