Increased Troponin-T level is associated with anthracycline-induced diastolic dysfunction of the left ventricle

Kilickap, S.; Barışta, İbrahim; Akgül, Ebru; Aytemir, Kudret; Aksöyek, Serdar; Celik, I.B.; S, Kes; Tekuzman, G.

doi:10.1200/jco.2004.22.14_suppl.9722

Cited by 1 publication

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“…Mechanisms responsible solely for diastolic dysfunction have not yet been clearly established. It was documented that increased serum troponin T levels can be detected in the early stages of anthracycline therapy, and these are associated with diastolic dysfunction of the left ventricle which leads to filling abnormalities 19 …”

Section: Discussionmentioning

confidence: 99%

Altered Left Ventricular Diastolic Performance in Oncologic Patients Treated With Epirubicin

Rădulescu

Pripon

Parv

et al. 2007

Congestive Heart Failure

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Anthracyclines confer an increased risk of cardiotoxicity. The authors evaluated left ventricular (LV) performance in patients treated with epirubicin. Sixty-eight patients with malignancies (study group), treated with epirubicin < or = 450 mg/m2, and a matched control group of 68 cancer patients who had not started chemotherapy were evaluated by Doppler echocardiography. The authors assessed LV diastolic function by measuring the transmitral flow: the maximal velocity of the E and A waves, the Emax/Amax ratio, the pressure half time of E wave (PHT), and the isovolumic relaxation time (IVRT). Global LV ejection fraction (LVEF) was estimated to determine the systolic performance. The authors documented alterations of the LV diastolic performance in the study group by finding a significant decrease in Emax, whereas Amax was significantly increased. Prolonged PHT and IVRT were also certified in the epirubicin-treated group compared with controls. No significant variation in LVEF between the 2 groups was detected.

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Section: Discussionmentioning

confidence: 99%