Increased Tumor Establishment and Growth After Laparotomy vs Laparoscopy in a Murine Model

Allendorf, John D.; Bessler, Marc; Kayton, Mark L.; Oesterling, Scott D.; Treat, Michael R.; Nowygrod, Roman; Whelan, Richard L.

doi:10.1001/archsurg.1995.01430060087016

Cited by 240 publications

(157 citation statements)

References 27 publications

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…Experimental data suggest that surgical trauma may be associated with increased tumour growth (21)(22)(23)(24)31). Various potential mechanisms have been identified demonstrating a correlation between surgical trauma and tumour growth (6,25,26,31).…”

Section: Discussionmentioning

confidence: 99%

Increased growth factor expression after hepatic and pancreatic resection

Justinger

Schlüter²,

Oliviera-Frick³

et al. 1994

Oncol Rep

View full text Add to dashboard Cite

Abstract. Removal of the primary tumour is suggested to associate with an enhanced tumour growth of residual micrometastases. Recent data focus on growth factors that may be released in response to surgery-stimulating receptors of residual tumour cells. Vascular endothelial (VEGF) and hepatocyte growth factor (HGF) are potent inducers of angiogenesis. The two factors are necessary for wound healing and the promotion of tumour growth. This study was designed to determine growth factor serum levels in patients before, during and after major abdominal surgery. It was recently shown that simultaneous hepatic and pancreatic resection led to poor liver regeneration. As growth factors may be involved in these findings we compared the growth factor levels after liver resection with the levels in patients after pancreatic resection. Forty patients were accrued before hepatopancreatic surgery (hepatic resection n=20 and pancreatic resection n=20). Blood samples were taken from each patient immediately prior to surgery, during the operation and on the postoperative days (POD) 1-3, 5 and 10. To examine the wound fluid, liquid from the wound drains was collected on POD 3. Using ELISA the concentration of the angiogenic cytokines HGF and VEGF 165 was determined. After the liver and pancreatic resections, circulating HGF and VEGF 165 were increased. We found significantly higher levels of HGF on POD 1-3 (p<0.01), compared to preoperative results with a peak on POD 2. After measuring the postoperative VEGF 165 levels we found significantly higher levels of circulating VEGF 165 on POD 1-5 (p<0.01) compared to the preoperative levels. On comparing liver with pancreatic resection we did not detect significantly different levels of the two growth factors in the two groups. VEGF 165 and HGF concentrations measured during the operation demonstrated no change. HGF and VEGF 165 levels detected in the wound fluid on POD 3 were ~10 times higher than the preoperative serum levels, respectively. In summary, our data show increased VEGF 165 and HGF levels after hepatopancreatic surgery. Notably, the lack of an impact of the type of organ resection on the concentration-time curve of the two growth factors suggest that high postoperative growth factor levels are part of normal wound healing and systemic inflammation. Thus, the proangiogenetic potential of growth factors may account for accelerated tumour growth when residual tumour cells are exposed to high levels of VEGF 165 and HGF.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased growth factor expression after hepatic and pancreatic resection

Justinger

Schlüter²,

Oliviera-Frick³

et al. 1994

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…It has been hypothesized that surgical resection of tumors may paradoxically contribute to the development of cancer recurrences. Murine studies have shown those laparotomy and bowel resections are associated with increased tumor growth and establishment vs results in anesthesia control mice [3][4][5] . In humans, numerous case reports have noted increased tumor growth soon after surgery in patients with residual cancer [6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

Kumara

Gaita

Miyagaki

et al. 2016

WJGO

View full text Add to dashboard Cite

AIM:To assess blood chitinase 3-like 1 (CHi3L1) levels for 2 mo after minimally invasive colorectal resection (MICR) for colorectal cancer (CRC). METHODS: CRC patients in an Institutional ReviewBoard approved data/plasma bank who underwent elective MICR for whom preoperative (PreOp), early postoperative (PostOp), and 1 or more late PostOp samples [postoperative day (POD) 7-27] available were included. Plasma CHi3L1 levels (ng/mL) were determined in RESULTS:PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/ mL (n = 80). Significantly elevated (P < 0.001) median plasma levels (ng/mL) over PreOp levels were detected on POD1 (667.7 CI: 495.7, 771.7; n = 79), POD 3 (132.6 CI: 95.5, 173.7; n = 76), 136.9; n = 62), 287.4; n = 22), 137.4; n = 20, P = 0.001).No significant difference in plasma levels were noted on POD27-41.CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.

show abstract

“…Laparoscopically assisted vaginal hysterectomy has become the preferred approach for cervical cancer treatment. Experimental studies have shown that laparoscopic surgery has a low impact on cancer growth (15)(16). Mounting evidence shows that cervical cancer recurrence and survival rates after laparoscopic surgery are comparable with those observed after laparotomy, despite the results of prospective randomized trials.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of surgical stress of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy and laparotomy for early-stage cervical cancer

Hou

Jiang

et al. 2011

Oncology Letters

View full text Add to dashboard Cite

Abstract. The aim of this study was to objectively evaluate the benefits of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy for early-stage cervical cancer. Clinical data were prospectively collected from patients with IA-IIB cervical cancer who underwent laparoscopically assisted vaginal radical hysterectomy (n1=33) and laparotomy (n2=30). Peripheral blood samples were obtained prior to surgery and at 1 and 2 h into the operation, as well as on days 1, 4 and 7 following surgery to measure serum interleukin-6, C-reaction protein and cortisol. Results showed that there was no conversion to laparotomy in the laparoscopy group. The average blood loss was 317.23±217.20 ml (laparoscopy group) and 872.58±693.16 ml (laparotomy group). No significant difference was found in the number of resected pelvic lymph nodes (19.74±7.43 in the laparoscopy group and 20.35±6.62 in the laparotomy group). At days 1 and 7 after surgery, the serum IL-6 level was significantly different in the laparoscopy and laparotomy groups (day 1: laparoscopy group 17.14±16.53 pg/ml and laparotomy group 34.32±20.97 pg/ml, p= 0.001; day 7: laparoscopy group 6.7±7.21 pg/ml and laparotomy group 17.54±16.47 pg/ml, p=0.001). The serum CRP level was significantly different at days 1 and 7 after the operation (day 1: laparoscopy group 7024.72±949.12 ng/ml and laparotomy group 7586.61±869.42 ng/ml, p=0.018; day 7: laparoscopy group 4357.71±2108.85 ng/ml and laparotomy group 6967.96±995.02 ng/ml, p<0.001). A significant difference was noted in the serum cortisol level at day 4 after the operation (122.29±65.17 ng/ml in the laparoscopy group and 186.76±68.61 ng/ml in the laparotomy group, p<0.001). In conclusion, the differences in clinical data and the various parameters pertinent to surgical stress evaluated in this study suggest that laparoscopic surgery for cervical cancer causes less postoperative stress than conventional open surgery.

show abstract

Increased Tumor Establishment and Growth After Laparotomy vs Laparoscopy in a Murine Model

Cited by 240 publications

References 27 publications

Increased growth factor expression after hepatic and pancreatic resection

Increased growth factor expression after hepatic and pancreatic resection

Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

Comparative evaluation of surgical stress of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy and laparotomy for early-stage cervical cancer

Contact Info

Product

Resources

About