1964
DOI: 10.1172/jci104990
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Increased Unbound Cortisol in the Plasma of Estrogen-treated Subjects*

Abstract: The plasma cortisol 1 level is the sum of the cortisol bound to the plasma proteins and that which is unbound. During pregnancy or estrogen treatment the plasma cortisol and 17-hydroxycorticoid level rises several-fold (1)(2)(3)(4)(5)(6)(7)(8). This rise is secondary to an increase in the plasma content of transcortin (6, 9), which is a normal a-globulin component of plasma (10) with high affinity for binding cortisol. Since the subject maintained on long term estrogen therapy does not develop the clinical sti… Show more

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Cited by 73 publications
(24 citation statements)
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“…The lack of significant increase of plasma dialyzable cortisol after estrogen differs from other reports of an increase in nonprotein-bound corticosteroid in pregnancy or after estrogen treatment (22)(23)(24), but this may be due to the short period of treatment in this study.…”
Section: Discussioncontrasting
confidence: 99%
“…The lack of significant increase of plasma dialyzable cortisol after estrogen differs from other reports of an increase in nonprotein-bound corticosteroid in pregnancy or after estrogen treatment (22)(23)(24), but this may be due to the short period of treatment in this study.…”
Section: Discussioncontrasting
confidence: 99%
“…Similar elevations have also been reported for unbound cortisol concentrations (Plager et at., 1964;Burke, 1969) and this effect has been shown to be the result of decreased clearance rather than increased production of cortisol (Layne et at., 1962 (Meffin et al, 1984). Given the two-fold higher cortisol concentrations in oral contraceptive users, such a mechanism could contribute to the inhibition of prednisolone clearance by oral contraceptives.…”
Section: Effects Of Cortisot On Prednisotone Ctearancesupporting
confidence: 86%
“…Doe (9) reported an increase in unbound cortisol using suction dialysis, and later showed by equilibrium dialysis (10) increased concentrations of unbound cortisol in pregnant subjects comparable to our results. Plager (11), using a method similar to ours, found no difference in the per cent filterable cortisol in males treated with 5 mg stilbestrol, but the concentration of filterable cortisol was almost quadrupled over untreated males. His results in normal males, however, are comparable to ours.…”
Section: Discussionsupporting
confidence: 56%