Increased Uptake of 18F-PSMA-1007 in Corpus Luteum Demonstrated by PET/CT

Abstract

Two women were referred for an 18 F-PSMA-1007 PET/CT in follow-up of an adenoid cystic tumor of the subglottic region and the bronchus, respectively. Only limited tracer uptake was seen in the region of local recurrence and in the region of known metastases. Unexpectedly, an incidental finding consisting of a high tracer uptake at a corpus luteum in the ovary was found in both women.

A Tale of 3 Tracers

“…Because leiomyoma is a benign tumor of the uterine smooth muscle cells, 18 F-fluciclovine uptake in it is congruent with the biodistribution of the radiotracer. Increased 18 F-PSMA-1007 has been previously reported in corpus luteal cyst 10 . This case, for the first time, presents a contrasting pattern of uptake of 68 Ga-PSMA and 18 F-fluciclovine and their relationship with the well-known uptake pattern of 18 F-FDG in different benign gynecological conditions.…”

“…Increased 18 F-PSMA-1007 has been previously reported in corpus luteal cyst. 10 This case, for the first time, presents a contrasting pattern of uptake of 68 Ga-PSMA and 18 F-fluciclovine and their relationship with the well-known uptake pattern of 18 F-FDG in different benign gynecological conditions. The 2 radiotracers ( 68 Ga-PSMA and 18 F-fluciclovine), which are commonly used in prostate cancer imaging, have the potential for use in imaging gynecological malignancies.…”

Increased 18F-PSMA and 18F-FDG Uptake in Lipomatous Hypertrophy of the Interatrial Septum

“…16 There is no evidence of increased 18 F-FDG uptake in other brown adipose tissue in our patient, and this theory has also been questioned by some authors, suggesting inflammation or other unknown mechanism of increased 18 F-FDG uptake. 17 To the best of our knowledge, we report the first case of repeated markedly increased 18 F-PSMA-1007 uptake in LHIS, another potential site of unspecific 18 F-PSMA-1007 uptake not related to prostate tissue, besides the well-known mostly benign unspecific bone uptake, 18 various benign disorders, [19][20][21][22][23][24][25][26][27][28] physiological uptake in different organs, 29 and uptake in other lipomatous benign or malignant tumors. 30,31 Although the exact uptake mechanism of 18 F-PSMA-1007 and 18 F-FDG in LHIS remains unclear, accurate analysis of the CT should be performed in cases of increased tracer uptake in the interatrial septum to rule out metastatic disease or lipomatous malignancies and confirm the diagnosis of an LHIS.…”

PSMA Uptake in a Subdural Hematoma

“…PSMA uptake has also been described in nonmalignant processes such as within lung consolidation from increased capillary permeability, 1 as well as Paget disease, which is thought secondary to osteoblastic activity 5 . Other nonprostatic entities have also demonstrated uptake of radiotracer, including a intracranial dermoid cyst, 6 corpus luteum, 7 compression fracture, 8 COVID-19 pneumonia, 9 and tubercular spondylitis 10 . Normal brain parenchyma shows a complete absence of PSMA radiotracer uptake secondary to an intact blood-brain barrier that the radiopharmaceutical does not normally cross 1 .…”