Increased uptake of serotonin in platelets from car painters occupationally exposed to mixtures of solvents and organic isocyanates.

Beving, H.; Malmgren, R.; Olsson, Per; Tornling, Göran; Unge, G

doi:10.5271/sjweh.2412

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…This is an important parameter in uptake studies, because induced effects hereon might explain the observed effects on uptake. This study indicate that the solvent induced effect on platelet 5-HT uptake, reported by Beving et al (1983), is not due to solvent induced reduction of 5-HT concentration at time zero of incubation. It also indicates a solvent induced effect on the 5-HT uptake mechanism.…”

Section: Resultssupporting

confidence: 58%

“…Recently Beving et al (1983) showed significantly accelerated platelet 5-HT uptake rate of platelets isolated from humans (n = 12) exposed to organic solvents compared to a nonexposed control group (n = 50). Similar effects on both platelet and synaptosomal 5-HT uptake are shown to be induced by a number of neurotoxic agents (Komulainen & Tuomisto 1981a, b & c;Tuomisto & Komulainen 1983a & b).…”

Section: Resultsmentioning

confidence: 99%

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Human Platelet 5‐Hydroxytryptamine Concentration as a Tool in Prediction of Solvent Induced Neurotoxic Effects

Lam¹,

Tarding²,

Stokholm³

et al. 1985

Acta Pharmacologica et Toxicologica

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Many organic solvents are lipophilic and concentrate in lipid rich tissues e.g. nervous tissue, where they are known to induce toxic effects in humans, especially in the central nervous system. Changes in the presynaptic neurotransmitter metabolism may play a role in these effects. The platelet is proposed as an alternative human model for this complex in the investigation of such changes, especially regarding 5‐hydroxytryptamine (5‐HT). The platelet 5‐HT concentration was measured in platelets isolated from exposed persons with diagnosed neurointoxication caused by exposure to organic solvents and compared to controls. No difference in the concentration was found. Instead of using the platelet 5‐HT concentration in the prediction of neurotoxic effects, the platelet 5‐HT uptake rate may be an alternative parameter. A specific and sensitive double isotope derivative technique for 5‐HT measurements is described. A solvent induced reduction in the number of platelets/ml platelet rich plasma was found and is discussed.

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Section: Resultssupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Human Platelet 5‐Hydroxytryptamine Concentration as a Tool in Prediction of Solvent Induced Neurotoxic Effects

Lam¹,

Tarding²,

Stokholm³

et al. 1985

Acta Pharmacologica et Toxicologica

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“…The intrapersonal variations in the content of platelet serotonin over time, at least for several months, are small ( Hervig et al ., 1996 ). Also, endogenous serotonin influences platelet functions, assayed as uptake or release of serotonin in vitro ( Beving et al ., 1983 ; Hervig & Farstad, 1996) and viability in vivo ( Aranda et al ., 1996 ).…”

mentioning

confidence: 99%

The swirling phenomenon in stored platelets is influenced by their endogenous serotonin

Hervig

Bakken

Farstad

1999

Transfusion Medicine

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The presence of the swirling phenomenon is useful to define platelet concentrates that are suitable for transfusion. If it is possible to identify donor-related factors which are related to persisting swirling during storage, it is possible to select platelet donors. Endogenous platelet serotonin content is stable and easily measured and related to agonist-induced serotonin secretion. During a 3-month period, the swirling in 825 single donor platelet concentrates was controlled before issue. Endogenous serotonin, % serotonin release and swirling were tested in 21 concentrates with poor or no swirling during storage. Sixty-three concentrates were randomly selected from the routinely prepared platelet concentrates and were routinely tested with the same analyses on days 1 and 7. To evaluate an obvious effect of endogenous serotonin on the swirling phenomenon, eight platelet concentrates prepared from buffy coat, each from four donors, were divided. One part was stored in the presence of 8.5 micromol serotonin L-1, and analysed as the control concentrates. The endogenous serotonin content in the 'low- swirling' concentrates was significantly lower than in the control group (P < 0.001). PCO2 and pH were significantly lower, and PO2 and MPV significantly higher than in the controls. In the control group, swirling after 7 days was significantly correlated with serotonin release. In the eight buffy-coat concentrates enriched in endogenous serotonin, both swirling and the percentage serotonin release were improved after storage for 10 days, compared with nonenriched concentrates. This study suggests that endogenous serotonin content and serotonin release are factors that may be of significance concerning preservation of the swirling phenomenon in platelet concentrates during storage.

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Study of the electrical impedance of blood from house painters

Beving

Tedner

1992

Int. Arch Occup Environ Heath

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Using a four-electrode technique the electrical impedance was measured at 150 kHz (100 microA) on whole blood samples from 13 male house painters (age 19-49 years; median 35 years) exposed occupationally to vapors from alkyd paints containing organic solvents and from a control group of 7 healthy unexposed men (age 27-53 years; median 37 years). The blood impedance of the two groups was monitored prior to and 9 days after an initial administration of acetylsalicylic (600 mg). The resistivity calculated from the impedance of whole blood from the painters remained significantly higher than the corresponding values for the controls. The hematological values for the two groups were within normal ranges, although the painters had significantly higher platelet counts than the controls. Effects of long-term exposure of the painters to volatile solvents are discussed.

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Increased uptake of serotonin in platelets from car painters occupationally exposed to mixtures of solvents and organic isocyanates.

Cited by 12 publications

References 20 publications

Human Platelet 5‐Hydroxytryptamine Concentration as a Tool in Prediction of Solvent Induced Neurotoxic Effects

Human Platelet 5‐Hydroxytryptamine Concentration as a Tool in Prediction of Solvent Induced Neurotoxic Effects

The swirling phenomenon in stored platelets is influenced by their endogenous serotonin

Study of the electrical impedance of blood from house painters

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