Increased urinary 8-hydroxy-2′-deoxyguanosine levels in workers exposed to di-(2-ethylhexyl) phthalate in a waste plastic recycling site in China

Wang, Qian; Wang, Li; Chen, Xi; Rao, Kai Min; Lu, Shao You; Sheng, Tao; Pu, Jun; Zheng, Dan; Xu, Shunqing; Zheng, Hong Yan; Wang, Jian Shu; Yu, Zhi Qiang; Rong, Zhang; Tao, Yong; Yuan, Jing

doi:10.1007/s11356-010-0420-1

Cited by 32 publications

(8 citation statements)

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“…Finally, the PAEs were injected to study the subchronic toxicity at the four sampling times. Based on the previous toxicity data of structurally similar PAEs (Christiansen et al, ; Kang et al, ; Chen et al, ; Wang et al, ; Piche et al, ) and a range‐finding test conducted prior to the experiment, a concentration of 10 mg/kg was ultimately chosen for the toxicity assessment. Each compound cohort at each point of time consisted of five fish.…”

Section: Methodsmentioning

confidence: 99%

A comparative study on antioxidant status combined with integrated biomarker response inCarassius auratusfish exposed to nine phthalates

Feng

Wang

2014

Environ. Toxicol.

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Laboratory experiments were performed to determine the antioxidant responses to nine phthalates (PAEs) in the liver of the goldfish Carassius auratus. The fish were injected with 10 mg/kg body weight of each PAE for 1 day and 4, 8, and 15 days. The potential biotoxicity of the PAEs were examined using the antioxidase and lipid peroxide indices. We determined that the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) levels displayed different trends following prolonged treatment, suggesting that metabolism generated either less toxic or more active substances. Based on the intensity of enzymes inhibition, MDA content, and the calculated integrated biomarker response (IBR), the toxicity order was determined as follows: dibutyl phthalate (DBP) > diethyl phthalate (DEP) > diisodecyl phthalate (DIDP) > diphenyl phthalate (DPP) > butyl benzyl phthalate (BBP) > diallyl phthalate (DAP) > dicyclohexyl phthalate (DCHP) > dimethyl phthalate (DMP) > di(2-ethylhexyl) phthalate (DEHP). In particular, DBP, which exhibited significant inhibition of enzyme activity and the greatest decrease in MDA content, may be a highly toxic contaminant. Furthermore, our results suggest that the IBR may be a general marker of pollution.

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Section: Methodsmentioning

confidence: 99%

A comparative study on antioxidant status combined with integrated biomarker response inCarassius auratusfish exposed to nine phthalates

Feng

Wang

2014

Environ. Toxicol.

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“…used in plastics is incorporated in PVC, with the remainder being used in cellulose polymers (Hahladakis et al, 2018;Wang et al, 2011).…”

Section: Phthalatesmentioning

confidence: 99%

“…In the third study, by Wang et al (2011), water and soil samples from a plastics recycling region in China were analysed for phthalate concentration and compared with reference samples. The plastics recycling area showed concentrations orders of magnitude greater than the reference areas indicating that the plastics recycling operations were a significant source.…”

Section: Phthalatesmentioning

confidence: 99%

“…To add context, Wang et al (2011) also analysed blood of occupationally exposed recycling workers, concluding that working in the plastics recycling industry is a significant independent predictor of higher urinary 8-OHdG (OR=2.323, p<0.01) for male workers, but not female workers (Table 13). One other study by Petrovičová et al (2016) detailed in Table 13, analysed the urine of Slovakian workers in the plastics extrusion sector, finding significantly (p<0.02) higher concentrations in those workers compared to waste collectors and the student control group.…”

Section: Phthalatesmentioning

confidence: 99%

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Plastic waste reprocessing for circular economy: A systematic review of risks to occupational and public health from legacy substances and extrusion

Cook¹,

Velis²,

Derks³

2020

Preprint

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Increasing aspirations to develop a circular economy for waste plastics will result in an expansion of the global plastics reprocessing sector over the coming decades. Here we focus on two critical challenges within the value chain that as a result of such increased circularity may exacerbate existing issues for occupational and public health (1): Legacy contamination in secondary plastics, addressing the risk of materials and substances being inherited from the previous use and carried through into new products when the material enters its subsequent use phase; and challenge (2): Extrusion of secondary plastics in reprocessing, an end process of conventional mechanical recycling of plastics, involving heating secondary plastics under pressure until they melt and can be formed into new products. Via a systematic review (PRISMA guidelines, adapted), we considered over 4,000 sources of information, refined and consolidated into 20 relevant sources, which were critically assessed. We also derive prevalent risk scenarios of hazard-pathway-receptor combinations, subsequently being ranked. Our critical analysis highlights that despite stringent regulation, industrial diligence and enforcement, occasionally small amounts of potentially hazardous substances are able to pass through these safeguards and re-enter in the new product cycle. Although many are present at concentrations unlikely to pose a serious and imminent threat, their existence may be an indication of a wider or possibly increasing challenge of pollution dispersion, as the plastics reprocessing sector proliferates. But, in the Global South context, such controls may not be in place. Several studies showed emission control by passive ventilation, through open doors and windows followed by dilution and dispersion in the atmosphere, resulting in increased occupational exposure. It is recommended that further investigations are undertaken to establish the scale and magnitude of such phenomena, especially given the limited evidence base, with results informing improved future risk management protocols of a circular economy for plastics.

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“…Some groups are more exposed to these chemicals than others. For instance, hospitalised patients are exposed through the use of infusion tubes and other medical devices, infants and toddlers through toys or ingestion of dust, and workers at plastic plants through their working environment [ 6 , 8 , 9 ]. The negative influence of phthalates, especially on the male reproductive system has given rise to restrictions in the use of these chemicals in children’s toys and child care products [ 8 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Phthalates on Cytokine Production in Monocytes and Macrophages: A Systematic Review of Experimental Trials

et al. 2015

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BackgroundPhthalates are a group of endocrine disrupting chemicals suspected to influence the immune system. The aim of this systematic review is to summarise the present knowledge on the influence of phthalates on monocyte and macrophage production and secretion of cytokines, an influence which could affect both pro- and anti-inflammatory abilities of these cells.Strategy and ResultsA systematic search was performed in Medline, Embase and Toxline in June 2013, last updated 3rd of August 2014. Criteria used to select studies were described and published beforehand online on Prospero (http://www.crd.york.ac.uk/NIHR_PROSPERO, registration number CRD42013004236). In vivo, ex vivo and in vitro studies investigating the influence of phthalates on cytokine mRNA expression and cytokine secretion in animals and humans were included. A total of 11 reports, containing 12 studies, were found eligible for inclusion. In these, a total of four different phthalate diesters, six primary metabolites (phthalate monoesters) and seven different cytokines were investigated. Though all studies varied greatly in study design and species sources, four out of five studies that investigated di-2-ethylhexyl phthalate found an increased tumour necrosis factor-α secretion/production from monocytes or macrophages. A summary of cytokine measurements was not possible since few studies were comparable in study design and due to insufficient reporting of raw data for most of the included studies.ConclusionResults from this review have suggested that at least one phthalate (di-2-ethylhexyl phthalate) has the ability to enhance tumour necrosis factor-α production/secretion from monocytes/macrophages in vitro, but also observed ex vivo. Influence of other phthalates on other cytokines has only been investigated in few studies. Thus, in vitro studies on primary human monocytes/macrophages as well as more in vivo studies are needed to confirm or dispute these findings.

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Increased urinary 8-hydroxy-2′-deoxyguanosine levels in workers exposed to di-(2-ethylhexyl) phthalate in a waste plastic recycling site in China

Abstract: The occupational DEHP exposure might contribute to oxidative deoxyribonucleic acid damage in the male workers.

Cited by 32 publications

References 50 publications

A comparative study on antioxidant status combined with integrated biomarker response inCarassius auratusfish exposed to nine phthalates

A comparative study on antioxidant status combined with integrated biomarker response inCarassius auratusfish exposed to nine phthalates

Plastic waste reprocessing for circular economy: A systematic review of risks to occupational and public health from legacy substances and extrusion

Influence of Phthalates on Cytokine Production in Monocytes and Macrophages: A Systematic Review of Experimental Trials

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