Increased urinary albumin excretion aggregates with atherosclerotic risk factors in type 2 (non-insulin-dependent) diabetes mellitus

Increased Transcapillary Escape Rate of Albumin in Microalbuminuric Type II Diabetic Patients

“…More recently, these findings have been confirmed in two prospective studies (10,11) in which, besides diabetes duration, age, and glycemic levels (3,8,9), other major atherosclerotic risk factors, such as smoking, body weight, high blood pressure (BP) (12)(13)(14), and lipid and lipoprotein abnormalities (15,16) frequently associated with microalbuminuria, were taken into account.…”

“…Increased cardiovascular risk in type II diabetic patients with microalbuminuria cannot be merely attributed to coexisting risk factors, such as higher BP (7), obesity (7), unfavorable lipid profile and lipoprotein composition (12)(13)(14)(15), elevation in serum lipoprotein(a) concentrations (16), smoking (10), poorer glucose control (7), and disorders of the hemostatic system (44). Thus, other mechanisms must be examined to explain the higher susceptibility of type II diabetic patients with microalbuminuria toward macrovascular disease (45).…”

Transcapillary Escape Rate of Albumin in Type II Diabetic Patients: The relationship with microalbuminuria and hypertension

“…The onset of microalbuminuria in diabetes heralds atherogenic abnormalities in lipid metabolism (9), disturbances in coagulation and fibrinolysis (10), and endothelial dysfunction (11)-all mechanisms that may link proteinuria with cardiovascular disease (12). Furthermore, microalbuminuria manifests at the glomerular level as part of a widespread increased microvascular permeability to macromolecules in normotensive diabetic patients with both IDDM (13) and NIDDM (14).…”