Increased Urinary Excretion of α1-Microglobulin at 6 Months after Transplantation is Associated with Urinary Excretion of Transforming Growth Factor-β1 and Indicates Poor Long-Term Renal Outcome

Teppo, Anna‐Maija; Honkanen, Eero; Finne, Patrik; Törnroth, T; Grönhagen‐Riska, Carola

doi:10.1097/01.tp.0000131816.51366.6b

Cited by 37 publications

(44 citation statements)

References 34 publications

(27 reference statements)

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“…In agreement with these data, Teppo et al (51,52) have recently observed that 60% of patients with increased urinary excretion of α-1-microglobulin at 6 months had renal function deterioration during a 4-year follow-up period. The authors measured 24-h urinary excretion of α-1-microglobulin, albumin and TGF-β in 79 renal transplant recipients with an average of 51 months post-transplantation.…”

Section: Tubular Proteins As Early Markers Of Ta/if Developmentsupporting

confidence: 60%

“…More importantly, they observed that 60% of patients with an α-1-microglobulin/creatinine ratio greater than 5 mg/ mmol presented a poor long-term outcome, namely renal function deterioration. It is worth to emphasize that they have initially shown that a sustained higher ratio of α-1-microglobulin/creatinine measured in urine predicted AR in renal transplanted patients and correlated with the duration of cold ischemia (51,52).…”

Section: Tubular Proteins As Early Markers Of Ta/if Developmentmentioning

confidence: 99%

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Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Câmara¹,

Williams

Pacheco-Silva³

2009

Braz J Med Biol Res

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New strategies are being devised to limit the impact of renal sclerosis on graft function. Individualization of immunosuppression, specifically the interruption of calcineurin-inhibitors has been tried in order to promote better graft survival once chronic graft dysfunction has been established. However, the long-term impact of these approaches is still not totally clear. Nevertheless, patients at higher risk for tubular atrophy and interstitial fibrosis (TA/IF) development should be carefully monitored for tubular function as well as glomerular performance. Since tubular-interstitial impairment is an early event in TA/IF pathogenesis and associated with graft function, it seems reasonable that strategies directed at assessing tubular structural integrity and function would yield important functional and prognostic data. The measurement of small proteins in urine such as α-1-microglobulin, Nacetyl-beta-D-glucosaminidase, alpha/pi S-glutathione transferases, β-2 microglobulin, and retinol binding protein is associated with proximal tubular cell dysfunction. Therefore, its straightforward assessment could provide a powerful tool in patient monitoring and ongoing clinical assessment of graft function, ultimately helping to facilitate longer patient and graft survival associated with good graft function.

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Section: Tubular Proteins As Early Markers Of Ta/if Developmentsupporting

confidence: 60%

Section: Tubular Proteins As Early Markers Of Ta/if Developmentmentioning

confidence: 99%

Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Câmara¹,

Williams

Pacheco-Silva³

2009

Braz J Med Biol Res

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“…Neste estudo, sete pacientes com IF/ TA apresentaram maior excreção urinária de TGF-b e atividade de renina plasmática, em resposta a inibidores de enzima conversora de angiotensina, do que aqueles sem IF/TA. 35 Teppo et al 36 avaliaram 79 receptores, 6 meses após o transplante renal, e verificaram que o aumento da excreção urinária de TGF-b está relacionado com a lesão tubular proximal e com a piora da função renal. Matl et al 37 O fator de crescimento epidermoide (EGF) é um peptídeo promotor de crescimento, que se encontra expresso na alça de Henle e no túbulo contorcido distal.…”

Section: Citocinas E Quimiocinas No Tecido Renal E No Sangue De Transunclassified

“…51 Os níveis de TGF-b têm sido correlacionados com excreção uriná-ria de albumina e de a1-microglobulina 6 meses após o transplante renal. 36 A elevação urinária do TGF-b tem sido associada também ao grau de fibrose intersticial na IF/TA. 52,53 Hu et al, 54 analisando amostras únicas de urina pré-biópsia renal de 99 pacientes, demonstraram elevação de I-TAC/CXCL11, MIG/CXCL9 e IP-10/ CXCL10 em vigência de RA, nefropatia por poliomavírus e NTA, mas não em casos de rejeição borderline, IF/TA e função estável de enxerto.…”

Section: Citocinas E Quimiocinas No Tecido Renal E No Sangue De Transunclassified

“…46 Como preditores de complicações e alterações futuras da função renal, os níveis de TGF-b e IP-10/CXCL10 apresentaram associação à função renal de 6 meses e 4 anos após o transplante. 35,36 IP-10/CXCL10, MIG/CXCL9, CXCR3, RANTES/ CCL5 e o percentual de ligação de IL-2 relacionaramse com a ocorrência de RA. 47 [70][71] A Tabela 2 resume os principais estudos sobre polimorfismo genético de citocinas/quimiocinas em transplantados renais.…”

Section: Citocinas E Quimiocinas No Tecido Renal E No Sangue De Transunclassified

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Citocinas e quimiocinas no transplante renal

et al. 2009

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Urinary proteomic analysis of chronic allograft nephropathy

O’Riordan

Orlova

Mendelev

et al. 2008

Proteomics Clinical Apps

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The pathogenesis of progressive renal allograft injury, which is termed chronic allograft nephropathy (CAN), remains obscure and is currently defined by histology. Prospective protocolbiopsy trials have demonstrated that clinical and standard laboratory tests are insufficiently sensitive indicators of the development and progression of CAN. The study aim was to determine if CAN could be characterized by urinary proteomic data and identify the proteins associated with disease. The urinary proteome of 75 renal transplant recipients and 20 healthy volunteers was analyzed using surface enhanced laser desorption and ionization MS. Patients could be classified into subgroups with normal histology and Banff CAN grades 2-3 with a sensitivity of 86% and a specificity of 92% by applying the classification algorithm Adaboost to urinary proteomic data. Several urinary proteins associated with advanced CAN were identified including α1-micro-globulin, β2-micro-globulin, prealbumin, and endorepellin, the antiangiogenic C-terminal fragment of perlecan. Increased urinary endorepellin was confirmed by ELISA and increased tissue expression of the endorepellin/perlecan ratio by immunofluoresence analysis of renal biopsies. In conclusion, analysis of urinary proteomic data has further characterized the more severe CAN grades and identified urinary endorepellin, as a potential biomarker of advanced CAN.

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Increased Urinary Excretion of α1-Microglobulin at 6 Months after Transplantation is Associated with Urinary Excretion of Transforming Growth Factor-β1 and Indicates Poor Long-Term Renal Outcome

Cited by 37 publications

References 34 publications

Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Proximal tubular dysfunction as an indicator of chronic graft dysfunction

Citocinas e quimiocinas no transplante renal

Urinary proteomic analysis of chronic allograft nephropathy

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