Increased urinary F2-isoprostanes levels in the patients with Alzheimer’s disease

Kim, Kyung Mee; Jung, Byung Hwa; Paeng, Ki‐Jung; Kim, Inseong; Chung, Bong Chul

doi:10.1016/j.brainresbull.2004.04.016

Cited by 43 publications

(23 citation statements)

References 23 publications

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“…However, the reasons for greater baseline F2-IsoPs in healthy children from those studies and ours compared with healthy adults10,11 are unclear. Higher levels of IsoPs increase were reported in moderately trained or untrained exercising adults29 as compared with trained adults,12 suggesting a role training status may play in IsoPs response to exercise.…”

Section: Discussionmentioning

confidence: 64%

“…Their urinary excretion provides an index of nonenzymatic lipid peroxidation,8 with 8-isoprostaglandin F 2 α being one of the most often studied F 2 -IsoPs in protocols involving human research. Such a high interest was largely driven by the fact that urinary excretion of 8-isoprostaglandin F 2 α was found in conditions associated with elevated oxidative stress, including overweight or obesity,9 atherosclerosis,7 type 2 diabetes,10 and neurodegenerative diseases 11…”

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confidence: 99%

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Increased Oxidative Stress in Healthy Children Following an Exercise Program: A Pilot Study

Nasca¹,

Zhang²,

Super³

et al. 2010

Journal of Developmental &Amp; Behavioral Pediatrics

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Exercise can induce oxidative stress or an imbalance between reactive oxygen species and cellular antioxidant defenses. Objective We investigated the effect of a real-life exercise program on systemic oxidative stress measured by urinary concentrations of 8-isoprostaglandin F2α (8-iso-PGF2α), a noninvasive index of lipid peroxidation, in a well-characterized pediatric group. Methods Healthy but primarily sedentary, 8- to 10-year-old children (n = 6, mean age 8.8 ± 0.9 years) of equally distributed healthy weight, overweight, and obese categories, participated in a 5-week exercise program (track and field summer camp, 2 hours/day, 1–2 days/week). Results By using high-performance liquid chromatography with online electrospray ionization tandem mass spectrometry (LC/ESI/MS/MS), we found a significant (p = .028) increase in group mean urinary 8-iso-PGF2α concentration from 8.163 ± 6.919 ng/mg creatinine pre-exercise program to 32.320 ± 16.970 ng/mg creatinine post-exercise program. The increase was also measured at each individual level. We found preliminary evidence that pre- and post-exercise program urinary 8-iso-PGF2α concentrations selectively correlated with children’s cardiometabolic characteristics and mood. Conclusion Our results warrant further exploration of the relationships between pre/post-exercise oxidative stress marker 8-iso-PGF2α and cardiometabolic characteristics, exercise habits, eating habits, and mood to determine whether increased post-exercise oxidative stress in healthy children is part of their normal adaptation to exercise or mediator of oxidative injury.

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Section: Discussionmentioning

confidence: 64%

mentioning

confidence: 99%

Increased Oxidative Stress in Healthy Children Following an Exercise Program: A Pilot Study

Nasca¹,

Zhang²,

Super³

et al. 2010

Journal of Developmental &Amp; Behavioral Pediatrics

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“…These is, therefore, important evidence that support the importance of 8-OHdG as a biomarker to complement NDDs diagnosis, and a faster methodology using MEPS/UHPLC-UV has been already described [90,110]. Regarding F2-isoprostanes as biomarkers of oxidative stress, unlike the CVDs ([105] and references within, [106,107]) and ODs [119], there are conflicting results about their role as biomarkers in different NDDs, such as AD, PD, ALS or Huntington’s diseases [124,125,126,127,128,129,130]. This inconsistency is probably due to the inability of some of the methodologies developed to differentiate between the several isoprostane isoforms, originating misleading results that need to be clarified with further studies.…”

Section: Metabolic Profiling Of Urine: Recent Trendsmentioning

confidence: 99%

Microextraction by Packed Sorbent (MEPS) and Solid-Phase Microextraction (SPME) as Sample Preparation Procedures for the Metabolomic Profiling of Urine

et al. 2014

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For a long time, sample preparation was unrecognized as a critical issue in the analytical methodology, thus limiting the performance that could be achieved. However, the improvement of microextraction techniques, particularly microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), completely modified this scenario by introducing unprecedented control over this process. Urine is a biological fluid that is very interesting for metabolomics studies, allowing human health and disease characterization in a minimally invasive form. In this manuscript, we will critically review the most relevant and promising works in this field, highlighting how the metabolomic profiling of urine can be an extremely valuable tool for the early diagnosis of highly prevalent diseases, such as cardiovascular, oncologic and neurodegenerative ones.

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“…With regard to AD, some studies have shown increased F2-isoprostane levels in plasma or urine of AD patients compared to age-matched controls [25-27], however these findings remain controversial [28-30]. In addition, increased CSF levels of F 2 -isoprostanes have also been shown in AD patients [25,28,31-33], which, importantly, can be suppressed by antioxidant treatment [34].…”

Section: Introductionmentioning

confidence: 99%

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

Casadesús

Smith

Basu

et al. 2007

Mol Neurodegeneration

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Increased urinary F2-isoprostanes levels in the patients with Alzheimer’s disease

Cited by 43 publications

References 23 publications

Increased Oxidative Stress in Healthy Children Following an Exercise Program: A Pilot Study

Increased Oxidative Stress in Healthy Children Following an Exercise Program: A Pilot Study

Microextraction by Packed Sorbent (MEPS) and Solid-Phase Microextraction (SPME) as Sample Preparation Procedures for the Metabolomic Profiling of Urine

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

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