Increased Urinary Glomerular Basement Membrane Products in Pyelonephritis

Glomerular Basement Membrane Antigens in Congenital and Acquired Nephrotic Syndrome in Childhood

“…The congenital nephrotic syndrome is a distinct disease entity with an autosomal recessive mode of inheritance [2], Because this illness is much more common in Finland than elsewhere, it has been designated congenital nephrotic syndrome of Finnish type (CNF) [3], The underlying defect in this disease is thought to be a disturbance in the synthesis of the glomerular base ment membrane (GBM) and perhaps of other basement membranes of the body as well [2], GBM antigens have been detected in the urine of clinically healthy persons [4], Such antigens are known to be excreted in increased amounts in experi mental glomerular disease [5][6][7], and both quantitative and qualitative alter-H U T T U N E N /H a L L M A N /R APOLA ations in the excretion of GBM antigens have also been observed in human renal disease [8][9][10][11][12]. K niker and P r in d iv il l e [10] and K nik er and Sweeney [12], reported that patients with congenital nephrotic syndrome excrete great amounts of a specific urinary antigen associated exclusively with this disease.…”