2017
DOI: 10.1101/226738
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Increased usage of antiseptics is associated with reduced susceptibility in clinical isolates of S. aureus

Abstract: 22Hospital acquired infection is a major cause of morbidity and mortality and regimes to 23 prevent infection are crucial in infection control. These include decolonisation of at-risk 24 patients of carriage of MRSA which is commonly achieved by protocols that include the use 25 of chlorhexidine, or octenidine as biocidal agents. There is however no standardised single 26 decolonisation regime agreed upon in the UK or other countries and protocols include a 27 variety of active agents. Antibiotic resistant bac… Show more

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Cited by 2 publications
(6 citation statements)
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“…Specifically, the ability of biocides to prime for antibiotic resistance without the usual observation of stable biocidal tolerance. Exposure of S. aureus to CHG did not reduce its susceptibility to the biocide, contrasting the findings of Hardy et al where prolonged exposure of S. aureus isolates to CHG led to reduced susceptibility (Hardy et al, 2017).…”
Section: Discussioncontrasting
confidence: 88%
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“…Specifically, the ability of biocides to prime for antibiotic resistance without the usual observation of stable biocidal tolerance. Exposure of S. aureus to CHG did not reduce its susceptibility to the biocide, contrasting the findings of Hardy et al where prolonged exposure of S. aureus isolates to CHG led to reduced susceptibility (Hardy et al, 2017).…”
Section: Discussioncontrasting
confidence: 88%
“…Exposure of S. aureus to CHG did not reduce its susceptibility to the biocide, contrasting the findings of Hardy et al where prolonged exposure of S . aureus isolates to CHG led to reduced susceptibility (Hardy et al, 2017). Here, cross‐resistance to oxacillin was observed with no corresponding tolerance to the biocide.…”
Section: Discussionmentioning
confidence: 99%
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“…These antimicrobials are integral to strategies aimed at reducing antibiotic use through enhanced infection control (Maillard, 2005). Accordingly, biocide use in clinical settings is increasing, particularly for prophylactic decolonization of newly admitted patients (Gilbert and Moore, 2005;Wand et al, 2017Wand et al, , 2019Hardy et al, 2018). This raises important questions about the impact of increased biocide use on bacterial pathogens, and there is evidence that sub-lethal biocide exposure can select for problematic species, reduced biocide susceptibility, and other undesirable traits (Hayden et al, 2015;Hardy et al, 2018;Wand et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Accordingly, biocide use in clinical settings is increasing, particularly for prophylactic decolonization of newly admitted patients (Gilbert and Moore, 2005;Wand et al, 2017Wand et al, , 2019Hardy et al, 2018). This raises important questions about the impact of increased biocide use on bacterial pathogens, and there is evidence that sub-lethal biocide exposure can select for problematic species, reduced biocide susceptibility, and other undesirable traits (Hayden et al, 2015;Hardy et al, 2018;Wand et al, 2019). In particular, there is increasing concern that inappropriate, or overuse, of biocides could lead to the emergence of "resistant" strains and select for crossresistance to antibiotics (Wand et al, 2017;Hashemi et al, 2019;Stein et al, 2019).…”
Section: Introductionmentioning
confidence: 99%