Increased vasopressor actions of intraventricular neuropeptide Y-(13–36) in spontaneously hypertensive versus normotensive Wistar-Kyoto rats. Possible relationship to increases in Y2 receptor binding in the nucleus tractus solitarius

Aguirre, J.A.; Hedlund, Peter B.; Narváez, José Ángel; Bunnemann, Bernd; Ganten, Detlev; Fuxé, Kjell

doi:10.1016/0006-8993(95)00408-i

Cited by 21 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…38 In regard to NPY receptors in rat brain stem, high densities of 123 I-NPY binding sites are found in the NST, and low densities are found in the DMN, 6,39 and Y2 receptors, as well as Y1 receptors, 40 are localized in the NST. 27,41 This anatomic evidence suggests that the NST is a more likely site of action for [Leu 31 , Pro 34 ]NPY to elicit stimulation of bile secretion compared with the DMN, as previously reported concerning the specific site for NPY action. 13 In the present study, the loci within the DVC that are stimulated by [Leu 31 , Pro 34 ]NPY were tried to determine by indicating the magnitude of the response in relation to the site of injection.…”

Section: Discussionsupporting

confidence: 73%

“…[11][12][13] There are still few reports that have revealed the specific receptor subtypes of NPY or PYY in the central nervous system for physiological regulations. 33,41,[43][44][45] In this study, the specific receptor subtype and specific site in the brain to elicit the stimulation of bile secretion have been characterized. In conclusion, NPY acts in the left DVC through Y1 receptor subtype to stimulate bile acid-independent and bicarbonatedependent bile secretion through vagus nerve.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropeptide Y stimulates bile secretion via Y1 receptor in the left dorsal vagal complex in rats

et al. 1998

View full text Add to dashboard Cite

Neuropeptide Y (NPY), a 36-amino acid peptide, was first isolated from porcine brain and is the member of a family of structurally related peptides that includes peptide YY (PYY) and pancreatic polypeptide. 1,2 NPY is localized in the central nervous system, as well as the peripheral nervous system. 3 In the brain, NPY immunoreactive nerve fibers and terminals and NPY receptors are localized in the paraventricular nucleus of the hypothalamus and the dorsal vagal complex (DVC), including the dorsal motor nucleus of the vagus (DMN) and the nucleus of the solitary tract (NST), 4-6 which are important sites for the autonomic nervous regulation of gastrointestinal function. 7 Central administration of NPY affects several physiological functions. 8 With respect to the gastrointestinal system, central injection of NPY modifies gastric and pancreatic secretion in animal models. 9,10 Recently, Farouk et al. observed that intracerebroventricular injection of NPY stimulates bile acid-independent bile secretion through vagal pathways in rats and dogs, 11 and we have confirmed this effect by intracisternal injection of NPY in rats. 12 Moreover, we have found very recently that the left vagal complex is the specific brain site of action for NPY to induce bile stimulation. 13 It is now generally accepted on the basis of functional and ligand binding studies that NPY binds to and activates six different receptor subtypes, designated Y1, 2, 3, 4 (PP receptor), 5, and 6. 14-18 Y1 receptors exhibit similar affinity for NPY, PYY and [Leu 31 , Pro 34 ]NPY analog, and poor affinity for the C-terminal fragments of NPY/PYY, while Y2 receptors display affinity for NPY/PYY and C-terminal fragments of the peptides but not to the Y1 and 3 selective agonist, [Leu 31 , Pro 34 ]NPY. 14,19-23 PYY has been suggested to have high affinity for Y1 and 2 receptors, and less affinity for Y3 receptors. 14,20,24 Although Y1 receptors were suggested as postsynaptic and Y2 receptors as presynaptic, 25 later studies demonstrated that Y2 receptors are also localized presynaptically. 26 Both Y1 and Y2 receptors are localized in the DVC, 27 which has been identified as the specific brain site for NPY to stimulate bile secretion. 13 Peripherally released PYY binds to the DVC, 28 and microinjection of PYY into the DVC modified gastrointestinal functions. 29,30 The identity of the receptor subtype for NPY in the medulla that mediates the stimulation of bile acid-independent and bicarbonate-dependent bile secretion remains to be established. The present studies were performed to address this question by examining the effect of microinjection of NPY and NPY analogs into the DVC on bile secretion in rats. MATERIALS AND METHODS Animals.Male Wistar rats weighing 270 to 330 g (Charles River Japan Inc., Yokohama, Japan) were housed in group cages under conditions of controlled temperature (22-24°C) and illumination (12-hour light cycle starting at 8 AM) for at least 7 days before the experiments. Animals were maintained on laboratory chow and tap water. Experiments w...

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y stimulates bile secretion via Y1 receptor in the left dorsal vagal complex in rats

et al. 1998

View full text Add to dashboard Cite

show abstract

“…This was accompanied by an increased density of Y 2 receptors (vasopressor effects) in the nucleus tractus solitarius (NTS). This suggests a dominance of the Y 2 over Y 1 receptor in the SHR [67]. A similar increase in Y 2 receptor mRNA was observed in the NTS 2 h after aortic co-arctation hypertension and correlated with the rapid increase in blood pressure in this model [68].…”

Section: Functional Npy Responsivenesssupporting

confidence: 69%

Neuropeptide Y and sympathetic control of vascular tone in hypertension

Westfall

Experientia Supplementum

View full text Add to dashboard Cite

“…Such an observation goes along with data in experimental hypertension [37]. Indeed, density of Y 2 receptor, the receptor that mediates the vasopressor effects of NPY, is higher than that of Y 1 receptor subtypes (vasorelaxant effects) in the nucleus tractus solitarius of spontaneously hypertensive rats [38]. On the contrary, apart from vasoconstriction, Y2 receptors also mediate the angiogenic effect of NPY [39,40], a response that appears of physiological relevance in myocardial remodelling in experimental animals and in humans.…”

Section: Discussionmentioning

confidence: 68%

Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients

Testa

Mallamaci

Macrì

et al. 2010

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

Increased vasopressor actions of intraventricular neuropeptide Y-(13–36) in spontaneously hypertensive versus normotensive Wistar-Kyoto rats. Possible relationship to increases in Y2 receptor binding in the nucleus tractus solitarius

Cited by 21 publications

References 32 publications

Neuropeptide Y stimulates bile secretion via Y1 receptor in the left dorsal vagal complex in rats

Neuropeptide Y stimulates bile secretion via Y1 receptor in the left dorsal vagal complex in rats

Neuropeptide Y and sympathetic control of vascular tone in hypertension

Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients

Contact Info

Product

Resources

About