Increased vincristine production from<i>Agrobacterium tumefaciens</i>C58 induced shooty teratomas of<i>Catharanthus roseus</i>G. Don

Begum, F.; Rao, Srinath; Rao, K. S.; Devi, Y Prameela; Giri, Archana; Giri, Charu Chandra

doi:10.1080/14786410802131153

Cited by 17 publications

(4 citation statements)

References 20 publications

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“…Tenfold higher accumulation of dimeric alkaloid vincristine compared to the untransformed control cultures was reported in the shooty teratoma of Catharanthus roseus which is developed by the infection of A. tumefaciens strain C58 using epicotyl and stem node explants [458]. Similar enhancement effect in terpenoid indole alkaloid production was observed in rol ABC HR lines of C. roseus which developed following the infection with A. tumefaciens strain A4 harboring rol ABC genes [459].…”

Section: Relationship Between Differentiation and Sms: Crown Galls Andmentioning

confidence: 53%

Morphogenesis, Genetic Stability, and Secondary Metabolite Production in Untransformed and Transformed Cultures

Halder¹,

Jha²

2020

Reference Series in Phytochemistry

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In addition to the primary metabolites, plants produce a vast number of chemically diversified economically valuable secondary metabolites (SMs) in specific cell types or tissue or organ of phylogenetically related family or genus or species or even to a single chemical race under tight environmental, developmental, and genetic control. Some SMs such as morphine and codeine are only synthesized in a particular organized and differentiated tissue or organ.

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Section: Relationship Between Differentiation and Sms: Crown Galls Andmentioning

confidence: 53%

Morphogenesis, Genetic Stability, and Secondary Metabolite Production in Untransformed and Transformed Cultures

Halder¹,

Jha²

2020

Reference Series in Phytochemistry

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“…A poisonous alkaloid chemical compound, Solasodine in shooty teratomas of Solanum eleagnifolium , was reported by Alvarez et al ( 1994 ). In some other plants, shooty teratomas are produced for secondary metabolites production, namely vincristine in Catharanthus roseus G. (Begum et al 2009 ; Begum 2011 ), naphthoquinone in Drosera capensis var. alba (Krolicka et al 2010 ).…”

Section: Main Textmentioning

confidence: 99%

In vitro strategies for the enhancement of secondary metabolite production in plants: a review

Fazili

Bashir

Ahmad³

et al. 2022

Bull Natl Res Cent

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Background Plants are the prime source of vital secondary metabolites (SMs) which are medicinally important for drug development, and these secondary metabolites are often used by plants in the various important tasks like defense against herbivory, interspecies defenses and against different types of stresses. For humans, these secondary metabolites are important as medicines, pigments, flavorings and drugs. Because most of the pharmaceutical industries are highly dependent on medicinal plants and their extraction, these medicinal plants are getting endangered. Main body Plant cell culture technologies are introduced as a viable mechanism for producing and studying SMs of plants. Various types of in vitro strategies (elicitation, hairy root culture system, suspension culture system, etc.) have been considerably used for the improvement of the production of SMs of plants. For the enhancement of SM production, suspension culture and elicitation are mainly used, but hairy root culture and other organ cultures are proved to satisfy the demand of secondary metabolites. Now, it is easy to control and manipulate the pathways that produce the plant secondary metabolites. Conclusions Techniques like plant cell, tissue and organ cultures provide a valuable method for the production of medicinally significant SMs. In recent years, most of the in vitro strategies are used due to knowledge and regulation of SM pathway in commercially valuable plants. In future, these things will provide a valuable method to sustain the feasibility of medicinal plants as the renewable sources of medicinally important compounds, and these methods will provide successful production of desired, important, valuable and also unknown compounds.

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“…Antidipsotropic activity and herbal remedy uses of daidzin for addiction to alcohol have also been reported (Rooke et al 2000;Lowe et al 2008). Plant tissue and organ cultures are considered as alternative for the supply of bioactive pharmaceutical secondary metabolites (Begum et al 2009;Murthy et al 2014). The hairy roots induced by Agrobacterium rhizogenes infection are genetically stable and grow rapidly in hormone-free media (Giri et al 2003;Chandra & Chandra 2011, Sharma et al 2013Murthy et al 2014).…”

Section: Introductionmentioning

confidence: 96%

Enhanced daidzin production from jasmonic and acetyl salicylic acid elicited hairy root cultures of Psoralea corylifolia L. (Fabaceae)

Zaheer

Reddy

Giri

2015

Natural Product Research

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Daidzin (7-O-glucoside of daidzein) has several pharmacological benefits in herbal remedy, as antioxidant and shown antidipsotropic activity. Hairy root culture of Psoralea corylifolia L. was developed for biomass and enhanced daidzin production using signalling compounds such as jasmonic acid (JA) and acetyl salicylic acid (ASA). Best response of 2.8-fold daidzin (5.09% DW) with 1 μM JA treatment after second week and 7.3-fold (3.43% DW) with 10 μM JA elicitation after 10th week was obtained from hairy roots compared to untreated control. ASA at 10 μM promoted 1.7-fold increase in daidzin (1.49% DW) content after seventh week compared to control (0.83% DW). Addition of 25 μM ASA resulted in 1.44% DW daidzin (1.5-fold increase) with 0.91% DW in control after fifth week and 1.44% DW daidzin (2.3-fold increase) after eighth week when compared to untreated control (0.62% DW). Reduced biomass with increased daidzin content was facilitated by elicited hairy root cultures.

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Increased vincristine production fromAgrobacterium tumefaciensC58 induced shooty teratomas ofCatharanthus roseusG. Don

Cited by 17 publications

References 20 publications

Morphogenesis, Genetic Stability, and Secondary Metabolite Production in Untransformed and Transformed Cultures

Morphogenesis, Genetic Stability, and Secondary Metabolite Production in Untransformed and Transformed Cultures

In vitro strategies for the enhancement of secondary metabolite production in plants: a review

Enhanced daidzin production from jasmonic and acetyl salicylic acid elicited hairy root cultures of Psoralea corylifolia L. (Fabaceae)

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