INCREASED Β-Endorphin BUT NOT MET-ENKEPHALIN LEVELS IN HUMAN CEREBROSPINAL FLUID AFTER ACUPUNCTURE FOR RECURRENT PAIN

Clement‐Jones, Vicky; Tomlin, Susan; Rees, Linford; McLoughlin, Lorraine; Besser, G. M.; Wen, H.L.

doi:10.1016/s0140-6736(80)92106-6

Cited by 346 publications

(59 citation statements)

References 19 publications

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“…The use of acupuncture for climacteric complaints has not up to now been well acknowledged, whereas acupuncture as treatment for pain is well investigated and accepted [16][17][18][19] . Physical exercise and acupuncture increase the activity of hypothalamic β-endorphin [20][21][22] and exercise has been associated with a lower prevalence of vaso-motor symptoms 23,24 . Since acupuncture is known to increase central β-endorphin activity, we want-ed to evaluate if this treatment could also ameli-orate flushes in women treated for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

et al. 2005

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Objective: To evaluate the effect of applied relaxation and electro-acupuncture on vasomotor symptoms in women treated for breast cancer.Methods: Thirty-eight postmenopausal women with breast cancer and vasomotor symptoms were randomized to treatment with electro-acupuncture (n = 19) or applied relaxation (n = 19) during 12 weeks. The number of hot flushes was registered daily in a logbook before and during treatment and after 3 and 6 months of follow-up.Results: Thirty-one women completed 12 weeks of treatment and 6 months of follow-up. After 12 weeks of applied relaxation, the number of flushes/24 h had decreased from 9.2 (95% confidence interval (CI) 6.6-11.9) at baseline to 4.5 (95% CI 3.2-5.8) and to 3.9 (95% CI 1.8-6.0) at 6 months follow-up (n = 14). The flushes/24 h were reduced from 8.4 (95% CI 6.6-10.2) to 4.1 (95% CI 3.0-5.2) after 12 weeks of treatment with electro-acupuncture and to 3.5 (95% CI 1.7-5.3) after 6 months follow-up (n = 17). In both groups, the mean Kupperman Index score was significantly reduced after treatment and remained unchanged 6 months after end of treatment. Conclusion:We suggest that applied relaxation and electro-acupuncture should be further evaluated as possible treatments for vasomotor symptoms in postmenopausal women with breast cancer.

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Section: Introductionmentioning

confidence: 99%

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

et al. 2005

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“…[14][15][16] Outside the countries where it has a long-standing history, acupuncture is mainly used in the treatment of chronic pain and as a analgetic procedure. 17,18 In urologic disorders, acupuncture has been successful both as primary or adjuvant therapy in enuresis, bladder instability and male infertility. [4][5][6][19][20][21][22][23] To our knowledge, only three papers on the use of acupuncture in erectile dysfunction have been presented in the international, peer-reviewed literature.…”

Section: Discussionmentioning

confidence: 99%

“…In median, the number of treatment sessions was 6.2 (range 4-10) and 11 (range [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] in the placebo group and in the treatment group, respectively. We could not observe any side effects according to acupuncture therapy.…”

Section: Acupuncture In Psychogenic Ed Pf Engelhardt Et Almentioning

confidence: 99%

Acupuncture in the treatment of psychogenic erectile dysfunction: first results of a prospective randomized placebo-controlled study

et al. 2003

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In a prospective study, we investigated the potentially curative effect of acupuncture in patients with psychogenic erectile dysfunction (pED). A total of 22 patients with pED were randomized into two groups. They were either treated with acupunture specific against ED (treatment group) or acupuncture specific against headache (placebo group). Nonresponders of the placebo group were crossed over to the treatment group. Prior to acupuncture, serum sexual hormone levels, IIEF score, nocturnal penile tumescence testing for three nights (Rigiscan) and the erectile response to 50 mg sildenafil were evaluated. Out of 21 patients, 20 completed the study, including 10 patients after crossover. A satisfactory response was achieved in 68.4% of the treatment group and in 9% of the placebo group (P ¼ 0.0017). Another 21.05% of the pateints had improved errections, that is, sufficient rigidity under simultaneous treatment with 50 gm sildenafil. The results of our pilot study indicate that acupuncture can be an effective treatment option in more than two-thirds of patients with psychogenic erectile dysfunction.

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“…The release of a morphine-like substrate in the central nervous system was hypothesized to be a possible mechanism of this analgesic action. Soon afterwards, -endorphin and enkephalin were purified and it was suggested that these opiates play a role in acupuncture in humans and animals (Clement-Jones, et al, 1980;Kiser, et al, 1983;Pert, et al, 1981). In humans, elevated levels of -endorphin in the cerebrospinal fluid and of plasma enkephalin were observed after acupuncture treatments.…”

Section: General Concepts Of the Mechanism Of Acupuncturementioning

confidence: 99%

Acupuncture Analgesia Research and Clinical Practice in Taiwan

Lin¹,

Chen²

2011

Acupuncture - Concepts and Physiology

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INCREASED Β-Endorphin BUT NOT MET-ENKEPHALIN LEVELS IN HUMAN CEREBROSPINAL FLUID AFTER ACUPUNCTURE FOR RECURRENT PAIN

Cited by 346 publications

References 19 publications

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

Acupuncture in the treatment of psychogenic erectile dysfunction: first results of a prospective randomized placebo-controlled study

Acupuncture Analgesia Research and Clinical Practice in Taiwan

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