Increases of calcium and phosphorus in the uterine arteries with aging

Abstract

To elucidate compositional changes of the uterine artery with aging, the authors investigated age-related changes of elements in the uterine arteries. After ordinary dissection by medical students at Nara Medical University was finished, the uterine arteries were resected from the subjects. The element content of the uterine arteries was analyzed by inductively coupled plasma-atomic emission spectrometry. The subjects ranged in age from 58 to 99 yr (average age = 82.7 +/- 10.1 yr). It was found that the Ca, P, and Na contents increased progressively in the uterine arteries with aging. A significant accumulation of Ca and P in the uterine arteries was found in the sixties and increased markedly in the eighties. It should be noted that as far as the arteries in those over 70 yr of age, the extent of accumulation of Ca and P was the highest in the uterine arteries within the limits of the arteries analyzed by us. Regarding the relationships among elements, significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na. As Ca increased in the uterine arteries, P, Mg, Zn, and Na increased simultaneously in the arteries.

Age-dependent Increases of Calcium, Phosphorus, and Sodium in the Uterine Arteries of Thai

“…The average content of Ca in the uterine arteries of Thai was lower than that in the internal iliac artery, coronary artery, abdominal aorta, and common iliac artery. Regarding the arteries of Japanese more than 70 years of age, the extent of accumulation of Ca and P was the highest in the uterine arteries within the limits of the arteries analyzed by us [7,17,18]. With regard to the extent of accumulation of Ca, a significant difference was found between the uterine arteries of Thai and Japanese.…”

“…Figure 3 shows the average content of Ca in the uterine arteries of Thai and Japanese by age group. Twenty-seven Japanese subjects ranged in age from 58 to 99 years (average age= 82.7±10.1 years) [7]. Although the average content of Ca in the uterine arteries of Japanese was similar to that of Thai in the seventies, the average content of Ca in the uterine arteries of Japanese in both the sixties and eighties was about two times higher compared with that of Thai.…”

“…They revealed that atherosclerosis of the uterine artery appeared to correlate with age. The authors [6,7] previously investigated age-related changes of elements in the uterine arteries of Japanese more than 58 years of age and found that a significant accumulation of Ca and P in the uterine arteries was found in the sixties and the accumulation increased markedly in the eighties. Regarding the uterine arteries in subjects more than 60 years, the extent of accumulation of Ca and P in the uterine arteries of Japanese [7] was two times higher than that in the uterine arteries of Thai with the exception of the seventies.…”

“…Therefore, the authors [6] previously investigated age-related changes of Ca in the branches of the internal iliac artery, such as the uterine, internal pudendal, umbilical, and obturator arteries, and found that a much higher accumulation of Ca occurred in the uterine artery with aging in comparison with the internal pudendal, umbilical, and obturator arteries. Furthermore, the authors [7] investigated age-related changes of six elements as well as Ca in the uterine arteries of Japanese and found that the Ca, P, and Na contents increased progressively in the uterine arteries with aging. To examine whether there was a race difference in age-related changes of the uterine arteries, the authors investigated age-related changes of elements in the uterine arteries of Thai.…”