Increases of CD80 and CD86 Expression on Peripheral Blood Cells and their Gene Polymorphisms in Autoimmune Thyroid Disease

Luteolin, inflammation and cancer: Special emphasis on gut microbiota

“…The last two, particularly, are closely associated with the development of autoimmune diseases. 30 Also, the production of inflammatory interleukins, such as IL-1, IL-6, IL-12 and TNF-α are down regulated. Flavonoids also reduce the production of IL-4 and TNF-α in eosinophils and inhibit mast-cell stimulation of Th17 lymphocytes 31 .…”

“…Mast cells are an important target of flavonoids, which can inhibit the expression of different clusters of differentiation (CD), particularly, CD‐40, CD‐80, CD‐86. The last two, particularly, are closely associated with the development of autoimmune diseases 30 . Also, the production of inflammatory interleukins, such as IL‐1, IL‐6, IL‐12 and TNF‐α are down regulated.…”

Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases

“…This investigation was based on a comprehensive analysis of the morphofunctional condition of the thyroid gland, systemic and local levels of cytokines, and intrathyroid expression of the costimulatory molecule CD86 by MC in induced thyrotoxicosis and Graves’ disease (GD). The signaling system through CD28 and CD152 involving CD80 and CD86 plays a crucial role in the induction and regulation of immune responses [7, 8]. The CD86 and CD80 molecules are coregulators of T-cell activation [7].…”

“…The signaling system through CD28 and CD152 involving CD80 and CD86 plays a crucial role in the induction and regulation of immune responses [7, 8]. The CD86 and CD80 molecules are coregulators of T-cell activation [7]. Additional markers, CD80 and CD86, appear on activated B cells, as opposed to resting B lymphocytes.…”

“…In addition to B lymphocytes, CD86 is constitutively expressed on interdigitating dendritic cells in the T zones of secondary lymphoid organs and in low quantities on Langerhans cells and peripheral blood dendritic cells [9, 10]. The overexpression of CD86 on monocytes was detected in peripheral blood of patients with ATD, and the expression of CD80, CD86, and CD40 was significantly increased on follicular B cells, but not on the marginal zone spleen B cells after the development of spontaneous autoimmune thyroiditis [7, 11]. Moreover, the association was found between polymorphisms of B7 molecules (CD86) and Graves' ophthalmopathy [12].…”