Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2<scp>DM</scp> cohort study

Leite, Nathalie C.; Villela-Nogueira, Cristiane Alves; Ferreira, Marcel T.; Cardoso, Claudia R.L.; Salles, Gil F.

doi:10.1111/liv.12994

Cited by 21 publications

(29 citation statements)

References 36 publications

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“…A previous study included 100 patients with biopsy‐proven NAFLD detected a positive association between cf‐PWV and histological liver fibrosis score . Leite et al also showed that both an elevated (cf‐PWV ≥10 m/s) and continuously increasing cf‐PWV predicted the progression of advanced liver fibrosis. Thicker CIMT also detected an independent association with the presence of significant liver fibrosis assessed using Fibroscan in asymptomatic general population .…”

Section: Discussionmentioning

confidence: 92%

“…The prevalence of NAFLD has dramatically increased in recent years, which is estimated to be approximately 25.2% worldwide and 23.3% in the Chinese population . NAFLD is the most common cause of chronic liver diseases and associated with end‐stage liver failure and hepatocellular carcinoma . Furthermore, NAFLD imposes excess risk of cardiovascular diseases (CVD), the leading cause of poor prognosis among the patients.…”

Section: Introductionmentioning

confidence: 99%

“…2 NAFLD is the most common cause of chronic liver diseases and associated with end-stage liver failure and hepatocellular carcinoma. 3 Furthermore, NAFLD imposes excess risk of cardiovascular diseases (CVD), the leading cause of poor prognosis among the patients. Currently, liver fibrosis is considered as the main indicator of prognosis in NAFLD.…”

Section: Introductionmentioning

confidence: 99%

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Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non‐invasive score

Xin

Zhu

Wang

et al. 2019

Liver International

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Background & Aims Nonalcoholic fatty liver disease (NAFLD) has been considered as a risk factor of adverse cardiovascular prognosis, but the relationship between subclinical atherosclerosis and NAFLD remains controversial. We aimed to investigate the impact of subclinical atherosclerosis on incident NAFLD and liver fibrosis. Methods We included 3433 subjects aged ≥40 years and free of NAFLD. Brachial‐ankle pulse wave velocity (ba‐PWV) and carotid intima‐media thickness (CIMT) were measured at baseline to assess subclinical atherosclerosis status. At follow‐up visit, NAFLD was diagnosed by hepatic ultrasound and fibrosis was assessed by NAFLD fibrosis score (NFS), fibrosis‐4 score (FIB‐4) and aspartate aminotransferase to platelet ratio index (APRI). Results A total of 654 (19.1%) subjects developed NAFLD during the follow‐up period of 4.3 years. In the multivariate logistic regression models, each standard deviation (SD) increment of ba‐PWV was associated with 20% (95% confidence interval [CI] 1.07‐1.33), 22% (95% CI 1.08‐1.39), 17% (95% CI 1.04‐1.32) and 37% (95% CI 1.07‐1.75) higher risk of incident NAFLD, higher NFS, FIB‐4 and APRI respectively. Compared with the lowest quartile of ba‐PWV, the highest quartile ba‐PWV had 63% (95% CI 1.20‐2.22), 112% (95% CI 1.42‐3.17), 86% (95% CI 1.28‐2.69) and 201% (95% CI 1.29‐7.04) higher risk of incident NAFLD, higher NFS, FIB‐4 and APRI respectively. Besides, per SD increase of CIMT was associated with a 12% (95% CI 1.01‐1.24) higher risk of incident NAFLD. Conclusions Increased ba‐PWV was independently associated with incident NAFLD and higher probability of fibrosis, whereas CIMT was associated with incident NAFLD but not with fibrosis.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non‐invasive score

Xin

Zhu

Wang

et al. 2019

Liver International

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“…Several previous studies [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ], resumed in Table 1 , have evaluated the relationships between NAFLD and arterial stiffness. All studies, except two of them [ 64 , 65 ], had cross-sectional designs, and all confirmed an association between increased arterial stiffness and NAFLD (mainly detected by ultrasonography), independent of other traditional cardiometabolic risk factors. Of note, one of these studies [ 56 ] demonstrated that the association between NAFLD and increased arterial stiffness was already present at adolescence.…”

Section: Aortic Stiffness and Nafldmentioning

confidence: 99%

NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?

Villela-Nogueira

Leite

Cardoso

et al. 2016

IJMS

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Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide. Liver inflammation and fibrosis related to NAFLD contribute to disease progression and increasing liver-related mortality and morbidity. Increasing data suggest that NAFLD may be linked to atherosclerotic vascular disease independent of other established cardiovascular risk factors. Central arterial stiffness has been recognized as a measure of cumulative cardiovascular risk marker load, and the measure of carotid-femoral pulse wave velocity (cf-PWV) is regarded as the gold standard assessment of aortic stiffness. It has been shown that increased aortic stiffness predicts cardiovascular morbidity and mortality in several clinical settings, including type 2 diabetes mellitus, a well-known condition associated with advanced stages of NAFLD. Furthermore, recently-published studies reported a strong association between NAFLD and increased arterial stiffness, suggesting a possible link in the pathogenesis of atherosclerosis and NAFLD. We sought to review the published data on the associations between NAFLD and aortic stiffness, in order to better understand the interplay between these two conditions and identify possible common physiopathological mechanisms.

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“…Results from the Rio-T2DM cohort study (n = 291) suggest that the presence of AS contributes substantially to liver fibrosis [14]. NAFLD in its initial form of simple steatosis is a rather benign situation without excess mortality, while NASH with advanced fibrosis increases total mortality by 70%, due to an increase in CVD mortality by nearly 300% [2].…”

mentioning

confidence: 99%

Arterial Stiffness and Nonalcoholic Fatty Liver Disease: Which is the Chicken and Which is the Egg?

Griva¹,

Boutari²,

Τζιόμαλος³

et al. 2017

TOHYPERJ

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Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio‐T2DM cohort study

Abstract: In T2DM patients with NAFLD, a high or increasing aortic stiffness predicted development of advanced liver fibrosis on TE.

Cited by 21 publications

References 36 publications

Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non‐invasive score

Associations of subclinical atherosclerosis with nonalcoholic fatty liver disease and fibrosis assessed by non‐invasive score

NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?

Arterial Stiffness and Nonalcoholic Fatty Liver Disease: Which is the Chicken and Which is the Egg?

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