Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica

Abstract

Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.

Antibacterial Activity of Solvothermal Obtained ZnO Nanoparticles with Different Morphology and Photocatalytic Activity against a Dye Mixture: Methylene Blue, Rhodamine B and Methyl Orange

“…The traditional methods for water purification include processes, e.g., sedimentation [ 4 ], flotation [ 5 ], filtration [ 6 ], adsorption [ 7 ], or chlorination [ 8 ], but the associated costs are important and they have limitations (e.g., do not remove the antibiotics). The use of nanomaterials for water purification is still in its infancy.…”

Antibacterial Activity of Zinc Oxide Nanoparticles Loaded with Essential Oils

“…Moreover, solventmediated loading can be carried out using adsorption, incipient wetness impregnation, solvent evaporation, supercritical and liquid CO 2 technology, one-pot drug loading and synthesis, chaperone assistance, etc. [35][36][37][38][39][40].…”

Health Benefits of Antioxidant Bioactive Compounds in the Fruits and Leaves of Lonicera caerulea L. and Aronia melanocarpa (Michx.) Elliot

“…The main components, polyphenols, flavonoids, and anthocyanins, are well studied for their antioxidant and antimicrobial activities or cytotoxicity. For oral administration of natural active substances, the need for a delivery system leads to specific requirements such as long-term controlled delivery avoiding the burst release effect, protecting the substances from low pH during stomach transit, delivery of substances at specific locations in the digestive system (see Figure 7 ), e.g., duodenum, jejunum, ileum, or colon [ 156 ]. The main flavonol in Aronia is quercetin, which has been extensively tested for its antitumoral applications, exhibiting also gastroprotective, antibacterial, and antiviral activities [ 157 , 158 , 159 ].…”

“… Digestive system disease treatment with mesoporous silica loaded with bioactive substances (realized with BioRender.com; accessed on 15th February 2023) [ 156 , 160 , 161 ]. …”