Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study

Mamun, Abdullah Al; Lawlor, Debbie A.; Alati, Rosa; O'Callaghan, MJ; Williams, Gail M.; Najman, Jake M.

doi:10.1038/sj.ijo.0803571

Cited by 58 publications

(71 citation statements)

References 22 publications

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“…19 There was insufficient data to combine the results from studies of dose-response associations; 3 studies for wheeze revealed a significant dose-response effect, 28-30 and 3 studies for asthma [31][32][33][34] revealed a significant dose-response effect; the significance could not be determined for 1 study, although the results did demonstrate increasing ORs. 32 However, 2 of the above studies also demonstrate a nonsignificant trend.…”

Section: Household Smokingmentioning

confidence: 75%

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

et al. 2012

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OBJECTIVES: Exposure to passive smoke is a common and avoidable risk factor for wheeze and asthma in children. Substantial growth in the prospective cohort study evidence base provides an opportunity to generate new and more detailed estimates of the magnitude of the effect. A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood. METHODS:We systematically searched Medline, Embase, and conference abstracts to identify cohort studies of the incidence of asthma or wheeze in relation to exposure to prenatal or postnatal maternal, paternal, or household smoking in subjects aged up to 18 years old. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using random effects model. RESULTS:We identified 79 prospective studies. Exposure to pre-or postnatal passive smoke exposure was associated with a 30% to 70% increased risk of incident wheezing (strongest effect from postnatal maternal smoking on wheeze in children aged #2 years, OR = 1.70, 95% CI = 1.24-2.35, 4 studies) and a 21% to 85% increase in incident asthma (strongest effect from prenatal maternal smoking on asthma in children aged #2 years, OR = 1.85, 95% CI = 1.35-2.53, 5 studies).CONCLUSIONS: Building upon previous findings, exposure to passive smoking increases the incidence of wheeze and asthma in children and young people by at least 20%. Preventing parental smoking is crucially important to the prevention of asthma. Pediatrics 2012;129:735-744 AUTHORS:

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Section: Household Smokingmentioning

confidence: 75%

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

et al. 2012

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“…[9][10][11][12][13][14][15][16][17] There are also some published studies that have not found any association between asthma and overweight in children. 19,27 These studies have a cross-sectional design in common; a prospective design is much more suitable for suggesting risk and direction of causation.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiologic studies suggest that overweight (most often measured as high BMI) at various ages increases the risk of asthma in childhood. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Despite this, the nature of the association between overweight and asthma is not completely understood, and only 1 study has looked at change in BMI status during childhood and the risk of asthma. 17 Results from a Dutch birth cohort showed that children with high BMI at age 6 to 7 years had an increased risk of asthma symptoms at age 8 years, whereas children with high BMI earlier in life and with normal weight at age 6 to 7 years did not.…”

mentioning

confidence: 99%

Early Childhood Overweight and Asthma and Allergic Sensitization at 8 Years of Age

Magnusson

Kull

Mai³

et al. 2012

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Overweight has been associated with an increased risk of asthma in children, although the published literature is contradictory. How change in overweight status during childhood affects asthma risk has not been well studied.WHAT THIS STUDY ADDS: Among children whose weight has normalized, high BMI during the first 4 years of life does not increase the risk of asthma at school age. Current high BMI is associated with increased risk of asthma and sensitization to inhalant allergens. abstract OBJECTIVES: Our aim was to examine the associations between high BMI and changes in BMI status during the first 7 years of life and asthma and allergic sensitization at age 8 years.METHODS: A birth cohort of newborn infants was followed for 8 years. Repeated parental questionnaires provided information on environmental exposures and health outcomes. Information on height and weight during childhood was retrieved from preschool and school health care records. The analyses included the 2075 children for whom information was available on weight and height, as well as on asthma, at age 8 years. RESULTS:A high BMI ($85th percentile) at age 1, 4, and/or 7 years was associated with an increased risk of asthma at age 8 years. However, no significant association was observed among children with high BMI at age 12 and/or 18 months (early age) or at age 4 years who developed a normal BMI by age 7 years. The risk was increased among children with high BMI at age 7 years, regardless of their earlier weight. Moreover, we observed an increased risk of sensitization to inhalant allergens among children with high BMI at age 7 years. CONCLUSIONS: Our study indicates that high BMI during the first 4 years does not increase the risk of asthma at school age among children who have developed a normal weight by age 7 years. However, high BMI at age 7 years is associated with an increased risk of asthma and sensitization to inhalant allergens.

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“…Mannino et al 37 showed that boys but not girls with body mass index (BMI) 485th percentile were at an increased risk of developing asthma later on. Recently Mamun et al 38 found that increased BMI z-scores between the ages of 5 and 14 years were associated with increased risk of asthma symptoms in adolescence, with a stronger, although not significant, association in the males. In this study, the relationship remained robust with adjustment for a range of reasons in early-life exposure such as a child's weight at birth, length of breastfeeding, maternal lifestyle during pregnancy, as well as diet, sports and TV watching at follow-up at 14 years.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, the relationship remained robust with adjustment for a range of reasons in early-life exposure such as a child's weight at birth, length of breastfeeding, maternal lifestyle during pregnancy, as well as diet, sports and TV watching at follow-up at 14 years. 38 Finally, in another study, the annual variations in BMI z-scores were significantly associated with asthma in girls. 39 Atopy is another important hallmark of childhood asthma as at least 90% of asthmatic children present clinically determined allergic sensitization.…”

Section: Introductionmentioning

confidence: 99%

Asthma and obesity in childhood: on the road ahead

2010

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Epidemiological data show a link between asthma and obesity, suggesting many different mechanisms that may underlie the association. However, diagnosis of asthma is often self-reported by patients or caregivers. Definition of asthma is crucial, particularly in childhood. Obesity can be associated with symptoms commonly attributed to asthma, such as wheezing, dyspnoea and sleep apnoea. Obese subjects are less fit and may have more frequent bouts of breathlessness on exertion accompanied by an exaggerated symptom perception. Therefore, the link between the two diseases should be analysed by focusing not only on reported diagnosis of asthma but also on objective markers that can better characterize the asthma phenotype. These markers should include lung function parameters, bronchial hyper-reactivity, atopic sensitization and indices of lung inflammation. As we look back and move forward, a multidisciplinary approach is increasingly necessary to understand the complexity of obesity and asthma, keeping in mind that diet and exercise could influence both diagnosis and treatment. In the meantime, in clinical settings, physicians should be cautious about diagnosing asthma in obese children on the basis of selfreported symptoms alone and should confirm the diagnosis by using objective measurements and marker evaluations that can better identify asthma phenotype and exclude overdiagnosis.

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Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study

Cited by 58 publications

References 22 publications

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

Early Childhood Overweight and Asthma and Allergic Sensitization at 8 Years of Age

Asthma and obesity in childhood: on the road ahead

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