Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling

Gutierrez, Nazareth Milagros Carigga; Pujol-Solé, Núria; Arifi, Qendresa; Coll, Jean‐Luc; Clainche, Tristan Le; Broekgaarden, Mans

doi:10.1007/s10555-022-10064-0

Cited by 12 publications

(5 citation statements)

References 371 publications

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“…EUS-PDT operates on the principle of employing EUS to precisely deliver photosensitizing drugs, which induces the generation of reactive oxygen species (ROS), consequently promoting cellular apoptosis and augmenting the permeability of tumor tissue ( 85 ). Choi et al ( 60 ) in 2015, used EUS-PDT in patients with advanced pancreaticobiliary malignancy, whereby they achieved a median necrotic volume of 4 cm 3 .…”

Section: Endoscopic Ultrasound-guided Ablationmentioning

confidence: 99%

“…EUS-PDT operates on the principle of employing EUS to precisely deliver photosensitizing drugs, which induces the generation of reactive oxygen species (ROS), consequently promoting cellular apoptosis and augmenting the permeability of tumor tissue (85) 63) pioneered the use of EUS-LA to treat patients with unresectable pancreatic cancer. In their study, they performed EUS-LA on a cohort of 9 patients, utilizing a power range of 2-4 watts and delivering energy in the range of 800-1,200 Joules.…”

Section: Endoscopic Ultrasound-guided Ablationmentioning

confidence: 99%

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EUS-guided interventional therapies for pancreatic diseases

Xu,

Zhang,

et al. 2024

Front. Med.

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Endoscopic ultrasound (EUS) is an integrated diagnostic technique merging endoscope and ultrasound to examine the digestive system. EUS has emerged as a primary diagnostic method for pancreatic diseases due to its distinctive benefits. Over the past four decades, EUS has undergone a transformation, shifting its role from primarily diagnostic to increasingly therapeutic. Additionally, in recent years, EUS has emerged as an increasingly prominent adjunctive or alternative approach to conventional surgical interventions. This review provides a comprehensive analysis of current technological approaches in the treatment of pancreatic diseases. The dynamic interplay with diverse therapeutic approaches has reinvigorated EUS and shaped its trajectory in the management of pancreatic diseases.

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Section: Endoscopic Ultrasound-guided Ablationmentioning

confidence: 99%

“…EUS-PDT operates on the principle of employing EUS to precisely deliver photosensitizing drugs, which induces the generation of reactive oxygen species (ROS), consequently promoting cellular apoptosis and augmenting the permeability of tumor tissue (85) 63) pioneered the use of EUS-LA to treat patients with unresectable pancreatic cancer. In their study, they performed EUS-LA on a cohort of 9 patients, utilizing a power range of 2-4 watts and delivering energy in the range of 800-1,200 Joules.…”

Section: Endoscopic Ultrasound-guided Ablationmentioning

confidence: 99%

EUS-guided interventional therapies for pancreatic diseases

Xu,

Zhang,

et al. 2024

Front. Med.

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“…All these PSs are porphyrin, chlorin, or phthalocyanine derivatives with strong absorption in the infrared (600-700 nm) or near-infrared (700-1000 nm) region, which allows for deep tissue penetration, improving treatment outcomes. Similarly, PDP can enhance vascular and cellular permeabilization, reduce stromal components (collagen, hyaluronan, and cancer-associated fibroblasts), and activate the immune response, leading to the improvement of chemotherapy or immunotherapy's individual therapeutic effectiveness, as shown in Figure 1 [14][15][16][17].…”

Section: Principles Of Photodynamic Therapy and Photodynamic Primingmentioning

confidence: 99%

Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management

Viana Cabral,

Quilez Alburquerque,

Roberts

et al. 2024

IJMS

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The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications.

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“…Photodynamic therapy (PDT) is primarily based on the accumulation of non-toxic photosensitizers, oxygen and light to produce reactive oxygen species (ROS), particularly singlet oxygen ( 1 O 2 ), which selectively induces apoptosis and necrosis in cancer cells [ 222 , 223 ]. It is a promising approach for cancer therapy due to its high selectivity, minimal invasiveness, significant efficacy, low impact on the host system, and many other advantages.…”

Section: H 2 S Diagnosis and Treatment Strategies ...mentioning

confidence: 99%