Increasing Ciprofloxacin Resistance Among Prevalent Urinary Tract Bacterial Isolates in Gaza Strip, Palestine

Astal, Z.

doi:10.1155/jbb.2005.238

Cited by 38 publications

(45 citation statements)

References 21 publications

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“…Many studies worldwide have reported a noticeable increase in resistance to ciprofloxacin and other fluoroquinolones. Ciprofloxacin is one of the most frequently prescribed fluoroquinolones for UTIs in adults because it has shown excellent activity against pathogens commonly encountered in complicated UTIs (21).…”

Section: Discussionmentioning

confidence: 99%

The Last Three Years Antibiotic Susceptibility Patterns of Uropathogens in Southwest of Iran

Valavi

Nikfar

Ahmadzadeh

et al. 2013

Jundishapur J Microbiol

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Background: Urinary tract infections are always treated empirically before the results of bacteriological cultures are obtained. The choice of antibiotics depends upon the causative organism and its expected local antibiotic susceptibility pattern. Objectives: We analyzed the spectrum and resistance patterns of uropathogens against common antimicrobial agents in Ahvaz Abuzar Children's Hospital, a tertiary care pediatric unit in southwest of Iran. Patients and Methods: In this retrospective study, all urine samples of children hospitalized with urinary tract infection (288 patients, aged 1mon -14.5 years) during October 2008 to May 2011 were included in the study. After bacteria were identified by standard methods, antimicrobial susceptibility testing was performed using a panel of antimicrobial agents. Results: The most of patients were girls (n = 226, 78.5%), and the median age was 13 months. The most common pathogens were Escherichia coli (84%), Klebsiella spp. (10.1%), Enterococcus spp. (2.4%), Proteus spp. (1.7%), and Pseudomonas spp. (1.7%). Overall bacterial resistance spectrum was the highest for co-trimoxazole (64.8%), followed by gentamicin (44.6%), amikacin (40.5%), nalidixic acid (37.3%), cefotaxime (28.9%), cefixime (27.5%), ceftriaxone (27.4%), and nitrofurantoin (10.2%). The female:male ratio was 2:1 (67.1% versus 32.9%) in infants aged < 1 year and 8:1 in those aged > 1 year (89.4% vs. 10.6%). Vesicoureteral reflux and abnormal sonography findings were associated with high resistance to cefotaxime (P = 0.017), ceftriaxone (P = 0.004), nitrofurantoin (P = 0.014), and nalidixic acid (P < 0.001). Conclusions: Increasing resistance to third-generation cephalosporins changed our opinion for using them as a single empiric intravenous therapy in hospitalized and very ill patients with acute pyelonephritis; the success will be achieved by concomitant use of an aminoglycoside or using other potent antibiotics.

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Section: Discussionmentioning

confidence: 99%

The Last Three Years Antibiotic Susceptibility Patterns of Uropathogens in Southwest of Iran

Valavi

Nikfar

Ahmadzadeh

et al. 2013

Jundishapur J Microbiol

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“…4 The prevalence of fluoroquinolone resistance in other regions of the world is similarly high. [54][55][56][57] Of note, these measures of resistance prevalence may overestimate resistance found in uncomplicated UTIs because surveillance of resistance of cystitis is rarely performed. 50 However, the last nationwide survey of antibiotic resistance among uropathogens causing outpatient UTIs was conducted in 2005, 58 and the prevalence of resistance may be higher.…”

Section: Discussionmentioning

confidence: 99%

Nitrofurantoin Compares Favorably to Recommended Agents as Empirical Treatment of Uncomplicated Urinary Tract Infections in a Decision and Cost Analysis

McKinnell

Stollenwerk

Jung

et al. 2011

Mayo Clinic Proceedings

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Objective: To analyze the costs of nitrofurantoin use compared to those of other antibiotics recommended for treatment of uncomplicated urinary tract infection (UTI). Patients and MethOds:We used a decision analysis model to perform cost-minimization and sensitivity analyses to determine the level of trimethoprim-sulfamethoxazole (TMP-SMX) and fluoroquinolone resistance that would favor the use of nitrofurantoin as a first-line empirical treatment of uncomplicated UTIs. The model used a program perspective to evaluate costs.Results: Nitrofurantoin was cost-minimizing when the prevalence of fluoroquinolone resistance exceeded 12% among uropathogens or the prevalence of TMP-SMX resistance exceeded 17%. On 2-way sensitivity analysis, variables that had a significant impact on our cost-minimization threshold included cost of antibiotics and probability of clinical cure with antibiotics.

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“…[1,3,7,14], but did show that ciprofloxacin resistance is escalating. [15] The Klebsiella SPP was exceedingly resistant to ampicillin (98%) followed by amoxicillin (90%), which showed highest resistance to any particular drug in this retrospective survey. This high resistance to ampicillin and amoxicillin by Klebsiella SPP was seen in many other studies.…”

Section: Resultsmentioning

confidence: 66%

Spectrum of Antimicrobial Susceptibility Pattern of Pathogens Isolated From Patients With Urinary Tract Infections in Tertiary Care Hospital in Hadoti Region of Rajasthan

Jain¹,

Saxena²

2015

jemds

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Antimicrobial drug resistance is one of the major threats due to wide spread use of antimicrobial drugs in general population. Also, it is known that the common infecting organism and pattern of resistance changes overtime. The present study highlights the trend of organism and their susceptibility patterns in the current scenario. A total number of 6350 samples were analysed in this institute during the study period. The study analysed resistance pattern of most common uropathogens in 30 antimicrobials of different classes. Culture positive cases of Urinary Tract Infections (UTI) were included for the analysis. About 12 different species of uropathogens were identified from 6350 cases. Among them E. coli was the most common uropathogen, which constituted 59.2% of the total samples followed by Klebsiella SPP (12.1%), Enterococcus SPP (10.1%) and Pseudomonas SPP (9.3%). Also female patients (58.5%) were more vulnerable to UTI than male patients (41.5%). Out of 30 antimicrobials tested, Ampicillin has shown the highest resistance by different uropathogens, i.e. 80.4% followed by ciprofloxacin (73%), amoxicillin (70.4%), norfloxacin (53.3%), while Penicillin, Furomycin, Doxycycline, Linezolid and Novobiocin offered least resistance. The present study identifies the changing etiologic trends of UTI and also a steady increase in development of antimicrobial resistance, especially against drugs which were highly effective.

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Increasing Ciprofloxacin Resistance Among Prevalent Urinary Tract Bacterial Isolates in Gaza Strip, Palestine

Cited by 38 publications

References 21 publications

The Last Three Years Antibiotic Susceptibility Patterns of Uropathogens in Southwest of Iran

The Last Three Years Antibiotic Susceptibility Patterns of Uropathogens in Southwest of Iran

Nitrofurantoin Compares Favorably to Recommended Agents as Empirical Treatment of Uncomplicated Urinary Tract Infections in a Decision and Cost Analysis

Spectrum of Antimicrobial Susceptibility Pattern of Pathogens Isolated From Patients With Urinary Tract Infections in Tertiary Care Hospital in Hadoti Region of Rajasthan

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