Increasing colorectal cancer incidence in individuals aged &lt; 50 years—a population-based study

Gutlic, Ida; Schyman, Tommy; Lydrup, Marie Louise; Buchwald, Pamela

doi:10.1007/s00384-019-03312-3

Cited by 15 publications

(14 citation statements)

References 23 publications

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“…In the USA, colorectal cancer is one of the 10 most commonly identified cancers among 20–49-year-olds [ 13 , 50 ]. Similar observations are signalled by Gutlic in the Swedish population, with an increase of 27–52% per decade for colon cancer observed in the age group below 50 years, both in men and women, while in cancer of the rectum it increased in men below 50 years of age, it decreased in both sexes 80+ years old, and remained unchanged in other age groups [ 60 , 61 ]. In turn, Park in his material of 226,352 cases has shown the percentage of patients under 39 years of age to be around 5% [ 51 ].…”

Section: Discussionsupporting

confidence: 70%

Dynamics of changes in colorectal cancer incidence in the Podkarpackie region (Poland) in the years 1963–2014

Gawełko¹,

Hejda²,

Radziewicz-Winnicki³

et al. 2021

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Introduction: Colorectal cancer (CRC) in Podkarpackie in Poland is the third most common cancer in males (12.6% cancer diagnoses), and second among women (10.1% of recognised cancers).Aim: An analysis of the trends in CRC incidence in the years 1963-2014 in Podkarpackie in the south-east of Poland. Material and methods: A total of 19,460 CRC cases recorded in the period 1963-2014 in the National Cancer Registry as ICD C18-C21 cases were analysed.Results: The overall cancer incidence rate in Podkarpackie Province was 20.4 in men and 16.8 in women per 100 thousand, and was lower than the Polish population by 12.4% for men and by 17.6% for women, respectively, in comparison to general Polish population rates. The mean age of CRC diagnosis grew from 64.0 years in males and 64.5 years in females in 1963-1969 to 67.6 and 68.4 years in 2010, respectively. Conclusions: In 1964 the CRC incidence rate in the Podkarpackie region increased 12.7-fold in males and 8.1-fold in females. There was an observed stable growth of average annual increase in the CRC incidence rate in men in 1963-1999, but since 2000 a decline in this rate has been observed. In females there was a tendency towards increased average CRC incidence rate in Podkarpackie since 2000, while in the whole country the female population presented a stable decrease of this coefficient.

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Section: Discussionsupporting

confidence: 70%

Dynamics of changes in colorectal cancer incidence in the Podkarpackie region (Poland) in the years 1963–2014

Gawełko¹,

Hejda²,

Radziewicz-Winnicki³

et al. 2021

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“…Incidence is rising in many countries [1], particularly among younger individuals [2]. There is good evidence that population screening reduces CRC incidence and mortality [3][4][5][6], and in most countries with a high frequency of CRC screening has now been introduced [7].…”

Section: Introductionmentioning

confidence: 99%

External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank

Saunders

Kilian

Thompson

et al. 2020

Cancer Prevention Research

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The aim of this study was to compare and externally validate risk scores developed to predict incident colorectal cancer (CRC) that include common genetic variants (single nucleotide polymorphisms, SNPs), with or without established lifestyle/environmental (questionnairebased/classical/phenotypic) risk factors. We externally validated 23 risk models from a previous systematic review in 443,888 participants aged 37-73 from the UK Biobank cohort who had 6 year prospective follow-up, no prior history of CRC and data for incidence of CRC through linkage to national cancer registries. There were 2,679 (0.6%) cases of incident CRC. We assessed model discrimination using the Area Under the Curve (AUC) and relative risk calibration. The AUC of models including only SNPs increased with the number of included SNPs and was similar in men and women: the model by Huyghe with 120 SNPs had the highest AUC of 0.62(95%CI 0.59-0.64) in women and 0.64(95%CI 0.61-0.66) in men.Adding phenotypic risk factors without age improved discrimination in men but not in women. Adding phenotypic risk factors and age increased discrimination in all cases (p<0.05), with the best performing models including SNPs, phenotypic risk factors and age having AUCs between 0.64-0.67 in women and 0.67-0.71 in men. Relative risk calibration varied substantially across the models. Among middle-aged people in the UK, existing polygenic risk scores discriminate moderately well between those who do and do not develop colorectal cancer over six years. Consideration should be given to exploring the feasibility of incorporating genetic and lifestyle/environmental information in any future stratified CRC screening program.

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“…In order to determine the risk of CRC and other gastrointestinal cancer following SBSEC-bacteremia, analyses were restricted to individuals without a prior diagnosis of CRC or metastasised cancer at the time of bacteremia – the incidence cohort. The association between subspecies and CRC, adjusted for potential confounders selected a priori , was analysed using logistic regression [ 1 , 2 , 9 ]. The covariates were investigated separately and in a full model including SBSEC-subspecies ( Sg gallolyticus versus other SBSEC-bacteremia), age groups (≤70, 71–80 and ≥81 years), sex, and if a focus of infection was determined.…”

Section: Methodsmentioning

confidence: 99%

“…Colorectal cancer (CRC) is the third most common cancer in Sweden and worldwide [ 1 ]. The incidence in Sweden is 62 per 100 000 population and increasing [ 2 ]. Despite this, the role of the gut microbiota in CRC carcinogenesis is yet sparsely studied.…”

Section: Introductionmentioning

confidence: 99%

Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study

et al. 2021

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This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236 (37%) followed by S. gallolyticus subsp. gallolyticus 58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) had S. gallolyticus subsp. gallolyticus-bacteremia. In contrast to other European studies, S. gallolyticus subsp. pasteurianus was the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated with S. gallolyticus subsp. gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia.

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Increasing colorectal cancer incidence in individuals aged < 50 years—a population-based study

Cited by 15 publications

References 23 publications

Dynamics of changes in colorectal cancer incidence in the Podkarpackie region (Poland) in the years 1963–2014

Dynamics of changes in colorectal cancer incidence in the Podkarpackie region (Poland) in the years 1963–2014

External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank

Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer: a retrospective cohort study

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